Cel The overall objective of this proposal is to develop a fast and cost-effective diagnostic tool for bacterial meningitis, i.e. the detection of Streptococcus pneumoniae and Neisseria meningitidis in cerebrospinal fluid.Kits, consisting of disposable sensing chips and separate detector units, will be developed. The tool shall be low priced and easy to use so that health workers with limited analytical training can employ the kits in the fieldThe tool shall lead to a faster diagnosis, speeding up a targeted antibiotics treatment, thus improving the survival chances of the patient, while facilitating the identification of the infection source and the isolation of individuals, in order to halt the epidemicsThe main project novelty is the use of aptamer receptors. Aptamers have several advantages over conventional antibodies e.g. significantly lower price, fast development and increased stability.Three sensor technologies will be developed aiming to obtain at least one commercial product by the end of the project. All technologies share the same aptamers and surface activation of the active area.The project success depends on a tight and well-planned collaboration between partners. Partner 1 will develop the S. pneumoniae and N. meningitidis aptamers, and will provide already available micro-organism specific aptamers for parallel sensor development.The near-market technology is evanescent fluorescence, already commercialised by Partner 2. Adaptation of the aptamers and of the Eva-Sensor Chip, will be done and validated in collaboration with Partners 1 & 3.Partner 1 will develop sensors based on microelectromechanical systems and liquid crystals. Either of these–acoustic and volumetric– technologies have, with limited commercial success, been used with molecular targets. Compared hereto targeting micro-organisms generate amplified signals. Partner 3 will design the fluidic chip incorporating the sensor. The resulting system will be commercialised by Partners 2 & 3 Dziedzina nauki natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologymaterials engineeringliquid crystals Program(-y) FP7-HEALTH - Specific Programme "Cooperation": Health Temat(-y) HEALTH.2012.2.3.0-1 - Diagnostics for infectious diseases in humans Zaproszenie do składania wniosków FP7-HEALTH-2012-INNOVATION-2 Zobacz inne projekty w ramach tego zaproszenia System finansowania CP-FP - Small or medium-scale focused research project Koordynator UNIVERSIDAD POLITECNICA DE MADRID Wkład UE € 1 062 578,28 Adres CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO 28040 Madrid Hiszpania Zobacz na mapie Region Comunidad de Madrid Comunidad de Madrid Madrid Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Gonzalo León (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko DAVOS DIAGNOSTICS AG Szwajcaria Wkład UE € 890 631,40 Adres OBERE STRASSE 22 7270 DAVOS PLATZ Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Max Wiki (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych JONSMAN INNOVATION APS Dania Wkład UE € 183 208,40 Adres HOVEDVEJEN 1d 3330 GORLOSE Zobacz na mapie Region Danmark Hovedstaden Nordsjælland Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Jacques Jonsman (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych BIOAPTER SOCIEDAD LIMITADA Zakończenie uczestnictwa Hiszpania Wkład UE € 38 085,17 Adres CALLE FORMENTERA EDIFICIO LAS ROZAS LOCAL 5 3 28230 LAS ROZAS MADRID Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Javier Vinós (Dr.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych