Final Report Summary - CEVAL (Clonal evolution in acute leukemia: from molecular and functional profiling towards therapeutic intervention) The CEVAL project aimed to address the functional mechanisms of clonal evolution and tumor progression in acute leukemia, and to use this knowledge to develop new strategies to detect and prevent leukemia initiation or relapse. We have focused on two human diseases which represent privileged models to study clonal evolution: Fanconi anemia (FA), a genetic condition predisposing to acute leukemia, and T-cell acute lymphoblastic leukemia (T-ALL), an aggressive leukemia with frequent leads to relapse. Using extensive genomic profiling and combination of functional and mice models, we were able to understand major mechanisms of tumor progression towards secondary leukemia (in Fanconi anemia) or relapse (in T-ALL), with immediate translational perspectives for patients through staging and treatment guidelines.
