Final Report Summary - TMUPIFE (Tracing Microbes using Phosphate in Fe-oxide Environments)
In addition to the microbial work, during her time at Yale University Dr. King was also approached by Dr. Skinner, a bone mineralization specialist, within the Department of Geology and Geophysics for help with an ongoing project related to bone mineralization. This project utilized Dr. King’s previous knowledge of spectroscopy to examine changes in the mineral components of bone between healthy mice and mice with a genetic condition which prevents adequate uptake of Ca and phosphate from their diet. The results of this work, one article has been accepted for publication and a second is currently in review, demonstrate that bone mineralogy varies depending on the extent of bone remodelling and the ability of the animal to provide enough Ca and phosphate to the mineral growth sites. The results of this study were presented at the Goldschmidt 2015 geochemistry conference in Prague. As for the microbial biomineralization work, this project has led to applications for further funding as an ongoing collaboration between Dr. King and Dr. Skinner as well as Dr. Tommasini, part of the Yale Medical School. This project has direct societal relevance as it uses a murine model of the human genetic disorder X-linked hypophosphatemia and alternative bone remodelling mechanisms active in hypophosphatemia patients may also be important for osteoporosis research.