Cel
The ultimate goal of our Consortium is to generate the necessary data to allow xenotransplantation to progress towards its initial clinical phase. The data generated during this project will encompass both efficacy and safety aspects of xeno-transplantation. Tools that will be used to reach this ambitious objective encompass state-of-the-art biomolecular technologies and in vivo models. XENOME aims to produce a "super-engineered" pig, i.e. a pig with a newly generated genotype that will improve the efficacy and safety profile of xenotransplantation. Assessments of efficacy will first take advantage of existing pig lines expressing human complement regulators, thrombomodulin (TM) and knock-out for a-Gal transferase. Using the most suitable background, further engineering will eliminate one or more PERV sequences. Additional transgenes, such as HO-1, CD39 and other molecules able to control immune responses, endothelial cell activation and subsequent microangiopathy, will be added.
The ultimate pig strain will thus combine the already available background with novel molecules exhibiting anti-inflammatory, anticoagulant and immunosuppressive properties. In addition, an effective immuno-suppression regimen will be defined and new pharmaceutical agents will be tested. A strong safety framework will also be established that may allow, at some stage, progression of xenotransplantation into the clinic. This will involve development of technologies enabling the timely diagnosis of infection, design of a safety plan for an efficacious containment of an untoward infectious event, breeding of a herd of "clean" source pigs, inactivation of PERV sequences and provide safety-related data deriving from long-term in vivo studies in primate xenograft recipients. Finally, the project will also provide a strong ethical, social (especially regarding public communication) and regulatory framework for xenotransplantation research (and possibly clinical application).
Dziedzina nauki
Zaproszenie do składania wniosków
FP6-2005-LIFESCIHEALTH-6
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
IP - Integrated ProjectKoordynator
PADOVA
Włochy
Zobacz na mapie
Uczestnicy (25)
TORQUAY
Zobacz na mapie
NANTES
Zobacz na mapie
LEIOA (BIZKAIA)
Zobacz na mapie
VIENNA
Zobacz na mapie
LONDON
Zobacz na mapie
NEUSTADT
Zobacz na mapie
GLASGOW
Zobacz na mapie
LA SERRA DI SAN MINIATO (PI)
Zobacz na mapie
PRAGUE
Zobacz na mapie
30623 HANNOVER
Zobacz na mapie
PADUA
Zobacz na mapie
CAMBRIDGE
Zobacz na mapie
KONSTANZ
Zobacz na mapie
PADOVA
Zobacz na mapie
UPPSALA
Zobacz na mapie
COIMBRA
Zobacz na mapie
LISBOA
Zobacz na mapie
9600 LEIDEN
Zobacz na mapie
GLASGOW
Zobacz na mapie
PARIS
Zobacz na mapie
GREIFSWALD, INSEL RIEMS
Zobacz na mapie
CREMONA
Zobacz na mapie
MILANO
Zobacz na mapie
MILAN
Zobacz na mapie
OTTIGNIES LOUVAIN-LA-NEUVE
Zobacz na mapie