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Zawartość zarchiwizowana w dniu 2024-05-29

The role of adherence factors of Pseudomonas aeruginosa in the continous modification of the host/pathogen relationship

Cel

Bacterial pathogens encountering host cells employ several attachment factors, which promote direct contact and trigger distinct signalling pathways in the host. The stimulation of particular signalling pathways subverts the eucaryotic cell and enables sur vival and persistence of bacteria within the host. Identification and characterisation of communicative tools between the bacteria and the host cells should lead to a better understanding of the infectious process and the development of new anti-infectious treatment. Pseudomonas aeruginosa is a Gram-negative bacterium causing nosocomial infections, wound infections, and lethal infections in Cystic Fibrosis patients. In the context of this proposal we aim at characterising the function of proteins encoded wi thin the P. aeruginosa cupB cluster, particularly that of the putative adhesins cupB6 and cupB5. The approach will employ cupB promoter studies to identify signals stimulating adhesion to eucaryotic cells. Expression levels of host cellular components upon infection with the wild type or cupB mutant strains will be analysed by high density DNA arrays. Cell lines with the Cystic fibrosis (CF) phenotype and Non CF cell lines will be used. Such an approach could be extended to other adhesins specific for epith elial cell - binding. The results will provide a specific profiling of gene expression and signalling pathways in response to the presence of particular adhesion factors in different P. aeruginosa strains.

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Temat(-y)

Zaproszenie do składania wniosków

FP6-2002-MOBILITY-5
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

EIF - Marie Curie actions-Intra-European Fellowships

Koordynator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Wkład UE
Brak danych
Adres
Rue Michel Ange 3
PARIS
Francja
Koszt całkowity
Brak danych