Cel
The proposed project is based on a family of international patents and other intellectual property owned by one of the consortium partners (BioDevelops). The patents claim the use" of a natural protein with immunomodulatory activity as a diagnostic marker and as a drug candidate. The natural protein has been named "Progesterone Induced Blocking Factor" or PIBF. It has been shown by one of the consortium partners (Pro-Gestatione) that PIBF blocks the autoimmune response which normally leads to the killing of rapidly growing tissue, such as foetuses. High levels of PIBF are absolutely essential for the maintenance of normal pregnancy, therefore PIBF resembles a promising drug target. During the characterization of PIBF as an important mediator for the maintenance of pregnancy, it has surprisingly been shown that tumour cells also express PIBF, whereas no or low PIBF reactivity is found in the adjacent normal tissues. This indicates that PIBF constitutes an essential marker for tumour cells.
The proposal describes the required steps to develop a novel testing assay to diagnose malignant tumours, to monitor tumour therapy and to diagnose premature abortion risk. The development of this diagnostic method is based on Development of a validated Enzyme Linked Immuno Sorbent Assay (ELISA), Research concerning the expression of PIBF in malignant tumours, Research concerning the expression of PIBF during normal and risk pregnancy For future development of PIBF as a novel drug target to support in vitro fertilization therapy it is envisioned to capitalise on the experience of one of the consortium partners (Intercell), a vaccine specialist.
To achieve this goal it is required to Fully characterise PIBF via analytical testing in order to obtain GMP material for safety testing. The strategic objectives of this proposal are Development of a convenient testing assay to diagnose malignant tumours, to monitor tumour treatment in patients and to diagnose premature abortion...
Dziedzina nauki
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesclinical medicineobstetricsfetal medicine
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- medical and health sciencesclinical medicineoncology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Zaproszenie do składania wniosków
FP6-2002-SME-1
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System finansowania
COOPERATIVE -Koordynator
SZEGED
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