Cel Extra-cellular recordings from excitable cell cultures using microelectrode arrays (MEAs) are now a well-accepted technique in both fundamental neuroscience research and applied electrophysiology. Nevertheless the current technological limitations restrict the mapping of spatio-temporal patterns capabilities of MEAs. In order to gain access to more detailed information on distributed processing, synaptic plasticity and spatially propagating activity patterns, the capabilities of recording the electrophysiological activity of increasingly complex electrogenic cell networks (i.e the MEAs mapping features) have to be upgraded. This requires the development of new high-resolution experimental tools. The aim of this project is to develop an enabling technology platform, based on an Active Pixel Sensor (APS) concept and signal and data processing algorithms for high spatial and temporal resolution recording and analysis of the electrophysiological activity of neuronal networks. The APS technology is used in CMOS cameras for example for fluorescence measurements. Our approach is based on changing the light-sensitivity pixel functionality to create a high-density array of metallic microelectrodes on a large active surface area. The APS-MEAs technology allows the integration of in-pixel and on-chip electronic circuits for signal amplification and high-speed addressing. The proposed technological platform together with the appropriate development of advanced signal and data processing algorithms will provide the scientific community a new validated experimental tool allowing to correlate local and intrinsic features at single cell and small neuronal network levels with global dynamic features of large assemblies of neurons. Dziedzina nauki natural sciencesbiological sciencesneurobiologyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensorsnatural sciencescomputer and information sciencesdata sciencedata processing Program(-y) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) NEST-2003-1 - Adventure activities Zaproszenie do składania wniosków FP6-2003-NEST-B-1 Zobacz inne projekty w ramach tego zaproszenia System finansowania NoE - Network of Excellence Koordynator UNIVERSITA DEGLI STUDI DI GENOVA Wkład UE Brak danych Adres Via Balbi 5 GENOVA Włochy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DÉVELOPPEMENT Szwajcaria Wkład UE Brak danych Adres Rue Jaquet-Droz 1 NEUCHÂTEL Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUT NATIONAL DE LA SANTÉ ET LA RECHERCHE MÉDICALE Francja Wkład UE Brak danych Adres Rue Tolbiac 101 PARIS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych SYDDANSK UNIVERSITET Dania Wkład UE Brak danych Adres Campusvej 55 ODENSE M Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITÉ DE NEUCHATEL Szwajcaria Wkład UE Brak danych Adres avenue du 1er Mars 26 NEUCHATEL Zobacz na mapie Koszt całkowity Brak danych