Cel
Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 patients, which will be used for better characterization of TBI and for Comparative Effectiveness Research (CER). The generalisability of our results will be reinforced by a contemporaneous registry level data collection in 15-25,000 patients. Our conceptual approach is to exploit the heterogeneity in biology, care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and identify effective clinical interventions. Key elements are the use of emerging technologies (biomarkers, genomics and advanced MR imaging) in large numbers of patients, across the entire course of TBI (from injury to late outcome) and across all severities of injury (mild to severe). Improved characterization with these tools will aid Precision Medicine, a concept recently advocated by the US National Academy of Science, facilitating targeted management for individual patients. Our consortium includes leading experts and will bring outstanding biostatistical and neuroinformatics expertise to the project. Collaborations with external partners, other FP7 consortia, and international links within InTBIR, will greatly augment scientific resources and broaden the global scope of our research. We anticipate that the project could revolutionize our view of TBI, leading to more effective and efficient therapy, thus improving outcome and reducing costs. These outcomes reflect the goals of CER to assist consumers, clinicians, health care purchasers, and policy makers to make informed decisions, and will improve healthcare at both individual and population levels.
Dziedzina nauki
Zaproszenie do składania wniosków
FP7-HEALTH-2013-INNOVATION-1
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-IP - Large-scale integrating projectKoordynator
2650 Edegem
Belgia
Zobacz na mapie
Uczestnicy (42)
CB2 1TN Cambridge
Zobacz na mapie
17177 Stockholm
Zobacz na mapie
3015 GD Rotterdam
Zobacz na mapie
37075 Goettingen
Zobacz na mapie
918 43 Trnava
Zobacz na mapie
7622 Pecs
Zobacz na mapie
20520 Turku
Zobacz na mapie
3012 Leuven
Zobacz na mapie
75012 Paris
Zobacz na mapie
Zakończenie uczestnictwa
20052 MONZA
Zobacz na mapie
Zakończenie uczestnictwa
20900 MONZA
Zobacz na mapie
Zakończenie uczestnictwa
CB10 1SA SAFFRON WALDEN
Zobacz na mapie
Zakończenie uczestnictwa
W1B 1AL LONDON
Zobacz na mapie
58455 Witten
Zobacz na mapie
2333 ZA Leiden
Zobacz na mapie
S10 2TN Sheffield
Zobacz na mapie
4000 Liege
Zobacz na mapie
Zakończenie uczestnictwa
80333 Muenchen
Zobacz na mapie
G12 0XH Glasgow
Zobacz na mapie
69120 Heidelberg
Zobacz na mapie
SW7 2AZ LONDON
Zobacz na mapie
Zakończenie uczestnictwa
02044 VTT ESPOO
Zobacz na mapie
02150 Espoo
Zobacz na mapie
FK9 4LA Stirling
Zobacz na mapie
3400 Hillerod
Zobacz na mapie
0450 Oslo
Zobacz na mapie
OX3 OBP Oxford
Zobacz na mapie
WD24 4QN Watford
Zobacz na mapie
20122 Milano
Zobacz na mapie
00014 Helsingin Yliopisto
Zobacz na mapie
94607 OAKLAND CA
Zobacz na mapie
32611 5500 Gainesville
Zobacz na mapie
45221-0222 Cincinnati
Zobacz na mapie
3800 Victoria
Zobacz na mapie
1020 Auckland
Zobacz na mapie
200127 SHANGHAI
Zobacz na mapie
17489 Greifswald
Zobacz na mapie
1080 WIEN
Zobacz na mapie
10117 Berlin
Zobacz na mapie
75008 Paris
Zobacz na mapie
94010 BURLINGAME
Zobacz na mapie
20126 MILANO
Zobacz na mapie