Final Report Summary - DOMDICAS (Dual Organo / Metal Desymmetrisation in Complex Alkaloid Synthesis)
The field of enantioselective catalysis has allowed the high efficiency in the synthesis of structurally complex and stereochemically defined molecules. In recent years, the synthetic comunity has demonstrated that the co-operative combination of aminocatalysis and transition metal catalysis is a powerful and versatile catalytic strategy for the enantioselective construction of C-C bonds, which opens the door to transformations unattainable by a single catalytic entity alone.
During the course of this project, we have developed two synthetic methodologies toward the morphan core from simple and readily available starting materials, involving simultaneously two types of catalysis. The nucleophile component is provided by enamine catalysis and the electrophile counterpart was generated by metal-activated π-systems.
Specifically, the desymmetrization of achiral alkyne-tethered cyclohexanones in a single step has been optimized to yield a family of morphan core derivatives in good yield and with excellent enantioselectivities. The dual catalyst system is formed by a chiral pyrrolidine, a silver salt and a cinchona-derived ligand. Besides the obvious benefits of a scalable reaction which can provide a large amount of a complex chiral product from a simple starting material, this unprecedented transformation has provided much useful information about the compatibility of different types of catalysis and about match/mismatch effects. Computational calculations were performed in order to rationalize the stereochemical outcome of this reaction.
As a complementary approach, the desymmetrization of achiral allene-tethered cyclohexanones was also explored, and a dual catalyst system formed by a different chiral pyrrolidine and a copper salt provided a different family of morphan core derivatives in good yield with moderate enantio- and diastereoselectivity.
In summary, we have successfully developed dual-catalyzed enantioselective methodologies for the synthesis of the morphan core. Given its reliability and scalability, this transformation is currently in use for the total synthesis of natural products containing the morphan core. Additionally, this research should be of great interest to the organic synthetic community as it advances the state of the art of dual catalysis, which will open the door to the discovery and development of novel reactivity.