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Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly

Cel

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a prevalence of 1.5-2% in European populations. By being a major cause of stroke, dementia, heart failure, and premature death, AF is a major threat to healthy ageing. Despite increasing knowledge on the diverse mechanisms that cause the AF substrate in individual patients, current strategies for prevention and therapy of AF remain largely unguided by mechanistic insights. As a result - with the exception of anticoagulation for the prevention of AF-related stroke – treatment of AF has thus far failed to improve patients’ outcome.
The CATCH ME consortium will bridge the present disconnect between our understanding of the molecular and electrophysiological mechanisms of AF and the current unstructured approach to its prevention and treatment. The consortium combines clinical, molecular, ECG engineering, and biostatistical expertise, and has access to large sets of human biological material (atrial tissue and bloods samples) and carefully phenotyped patient populations. Together, we will identify and integrate the main drivers of prevalent and incident AF in patients, and validate new ECG- and blood based markers in well-characterized cohorts. The results of these investigations will provide a quantitative estimate of the prevalence and impact of new and established risk factors for AF in Europe and uncover potential new targets and strategies for the prevention and treatment of this arrhythmia. We will integrate these factors into a new clinical classification of AF that will be externally validated in two large patient cohorts, including response to current treatment strategies, and AF-related complications. In summary, CATCH ME will
1. identify major AF-related modifiers of health in the elderly in Europe,
2. develop clinical tools that have the potential of transforming the management of AF in individual patients, and
3. inform future personalized strategies to prevent and treat AF in Europe.

Zaproszenie do składania wniosków

H2020-PHC-2014-two-stage
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

RIA - Research and Innovation action

Koordynator

THE UNIVERSITY OF BIRMINGHAM
Adres
Edgbaston
B15 2TT Birmingham
United Kingdom
Rodzaj działalności
Higher or Secondary Education Establishments
Wkład UE
€ 1 303 366,05

Uczestnicy (8)

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Hiszpania
Wkład UE
€ 462 500
Adres
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Rodzaj działalności
Other
UNIVERSITEIT MAASTRICHT
Niderlandy
Wkład UE
€ 718 187
Adres
Minderbroedersberg 4-6
6200 MD Maastricht
Rodzaj działalności
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Niemcy
Wkład UE
€ 562 000
Adres
Geschwister Scholl Platz 1
80539 Muenchen
Rodzaj działalności
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Wkład UE
€ 499 803,75
Adres
Wellington Square University Offices
OX1 2JD Oxford
Rodzaj działalności
Higher or Secondary Education Establishments
SORBONNE UNIVERSITE
Francja
Wkład UE
€ 383 367,50
Adres
21 Rue De L'ecole De Medecine
75006 Paris
Rodzaj działalności
Higher or Secondary Education Establishments
KOMPETENZNETZ VORHOFFLIMMERN E.V.
Niemcy
Wkład UE
€ 567 500
Adres
Mendelstrasse 11
48149 Muenster
Rodzaj działalności
Other
SOCIETE EUROPEENNE DE CARDIOLOGIE
Francja
Wkład UE
€ 397 037,50
Adres
Route Des Colles 2035
06903 Biot Sophia Antipolis
Rodzaj działalności
Other
THE UK HEALTH & ENVIRONMENT RESEARCH INSTITUTE LIMITED

Zakończenie uczestnictwa

United Kingdom
Wkład UE
€ 51 011,20
Adres
Pera Business Park Nottingham Road
LE13 0PB Melton Mowbray
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)