Antifreeze GlycoProtein Mimetic Polymers

Informazioni relative al progetto

CRYOMAT

ID dell’accordo di sovvenzione: 638661

DOI

10.3030/638661

Progetto chiuso

Data della firma CE 18 Maggio 2015

Data di avvio 1 Giugno 2015

Data di completamento 31 Maggio 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 496 439,00

Contributo UE

€ 1 496 439,00

Coordinato da

UNIVERSITY OF WARWICK
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (50)

High-Throughput Tertiary Amine Deoxygenated Photopolymerizations for Synthesizing Polymer Libraries

Autori: Christopher Stubbs, Thomas Congdon, Jessica Davis, Daniel Lester, Sarah-Jane Richards, Matthew I. Gibson
Pubblicato in: Macromolecules, Numero 52/20, 2019, Pagina/e 7603-7612, ISSN 0024-9297
Editore: American Chemical Society
DOI: 10.1021/acs.macromol.9b01714

Synthetically Scalable Poly(ampholyte) Which Dramatically Enhances Cellular Cryopreservation

Autori: Trisha L. Bailey, Christopher Stubbs, Kathryn Murray, Ruben M. F. Tomás, Lucienne Otten, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 20/8, 2019, Pagina/e 3104-3114, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b00681

Low DMSO Cryopreservation of Stem Cells Enabled by Macromolecular Cryoprotectants

Autori: Kathryn A. Murray, Ruben M. F. Tomás, Matthew I. Gibson
Pubblicato in: ACS Applied Bio Materials, Numero 3/9, 2020, Pagina/e 5627-5632, ISSN 2576-6422
Editore: ACS
DOI: 10.1021/acsabm.0c00638

Double-Modified Glycopolymers from Thiolactones to Modulate Lectin Selectivity and Affinity

Autori: Laura E. Wilkins, Nezha Badi, Filip Du Prez, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 7/12, 2018, Pagina/e 1498-1502, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.8b00825

Extracellular Antifreeze Protein Significantly Enhances the Cryopreservation of Cell Monolayers

Autori: Ruben M. F. Tomás, Trisha L. Bailey, Muhammad Hasan, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 20/10, 2019, Pagina/e 3864-3872, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b00951

Photochemical “In-Air” Combinatorial Discovery of Antimicrobial Co-polymers

Autori: Sarah-Jane Richards, Adam Jones, Ruben M. F. Tomás, Matthew I. Gibson
Pubblicato in: Chemistry - A European Journal, Numero 24/52, 2018, Pagina/e 13758-13761, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802594

Probing the causes of thermal hysteresis using tunable N agg micelles with linear and brush-like thermoresponsive coronas

Autori: L. D. Blackman, M. I. Gibson, R. K. O'Reilly
Pubblicato in: Polymer Chemistry, Numero 8/1, 2017, Pagina/e 233-244, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/C6PY01191H

Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity

Autori: Daniel E. Mitchell, Guy Clarkson, David J. Fox, Rebecca A. Vipond, Peter Scott, Matthew I. Gibson
Pubblicato in: Journal of the American Chemical Society, Numero 139/29, 2017, Pagina/e 9835-9838, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b05822

Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules

Autori: Daniel J. Phillips, James Harrison, Sarah-Jane Richards, Daniel E. Mitchell, Esther Tichauer, Alasdair T. M. Hubbard, Collette Guy, Ian Hands-Portman, Elizabeth Fullam, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 18/5, 2017, Pagina/e 1592-1599, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.7b00210

Identification of the anti-mycobacterial functional properties of piperidinol derivatives

Autori: Collette S Guy, Esther Tichauer, Gemma L Kay, Daniel J Phillips, Trisha L Bailey, James Harrison, Christopher M Furze, Andrew D Millard, Matthew I Gibson, Mark J Pallen, Elizabeth Fullam
Pubblicato in: British Journal of Pharmacology, Numero 174/14, 2017, Pagina/e 2183-2193, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.13744

Regioregular Alternating Polyampholytes Have Enhanced Biomimetic Ice Recrystallization Activity Compared to Random Copolymers and the Role of Side Chain versus Main Chain Hydrophobicity

Autori: Christopher Stubbs, Julia Lipecki, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 18/1, 2016, Pagina/e 295-302, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.6b01691

Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

Autori: Sangho Won, Sarah-Jane Richards, Marc Walker, Matthew I. Gibson
Pubblicato in: Nanoscale Horizons, Numero 2/2, 2017, Pagina/e 106-109, ISSN 2055-6756
Editore: Royal Society of Chemistry
DOI: 10.1039/c6nh00202a

“Grafting to” of RAFTed Responsive Polymers to Glass Substrates by Thiol–Ene and Critical Comparison to Thiol–Gold Coupling

Autori: Caroline I. Biggs, Marc Walker, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 17/8, 2016, Pagina/e 2626-2633, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.6b00662

Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger

Autori: Daniel J. Phillips, Thomas R. Congdon, Matthew I. Gibson
Pubblicato in: Polymer Chemistry, Numero 7/9, 2016, Pagina/e 1701-1704, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/c5py01948f

Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms

Autori: Sarah-Jane Richards, Klea Isufi, Laura E. Wilkins, Julia Lipecki, Elizabeth Fullam, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 19/1, 2017, Pagina/e 256-264, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.7b01561

Impact of sequential surface-modification of graphene oxide on ice nucleation

Autori: Caroline I. Biggs, Christopher Packer, Steven Hindmarsh, Marc Walker, Neil R. Wilson, Jonathan P. Rourke, Matthew I. Gibson
Pubblicato in: Physical Chemistry Chemical Physics, Numero 19/33, 2017, Pagina/e 21929-21932, ISSN 1463-9076
Editore: Royal Society of Chemistry
DOI: 10.1039/C7CP03219F

Ultralow Dispersity Poly(vinyl alcohol) Reveals Significant Dispersity Effects on Ice Recrystallization Inhibition Activity

Autori: Nicholas S. Vail, Christopher Stubbs, Caroline I. Biggs, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 6/9, 2017, Pagina/e 1001-1004, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.7b00595

Polyproline as a Minimal Antifreeze Protein Mimic That Enhances the Cryopreservation of Cell Monolayers

Autori: Ben Graham, Trisha L. Bailey, Joseph R. J. Healey, Moreno Marcellini, Sylvain Deville, Matthew I. Gibson
Pubblicato in: Angewandte Chemie International Edition, Numero 56/50, 2017, Pagina/e 15941-15944, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201706703

Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection

Autori: Angela Casillo, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, Sandro Cosconati, Ettore Novellino, Antonio Randazzo, Maria L. Tutino, M. Michela Corsaro
Pubblicato in: Carbohydrate Polymers, Numero 156, 2017, Pagina/e 364-371, ISSN 0144-8617
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2016.09.037

Polymer mimics of biomacromolecular antifreezes

Autori: Caroline I. Biggs, Trisha L. Bailey, Ben Graham, Christopher Stubbs, Alice Fayter, Matthew I. Gibson
Pubblicato in: Nature Communications, Numero 8/1, 2017, Pagina/e 1546, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-01421-7

Synthesis of Degradable Poly(vinyl alcohol) by Radical Ring-Opening Copolymerization and Ice Recrystallization Inhibition Activity

Autori: Guillaume Hedir, Christopher Stubbs, Phillip Aston, Andrew P. Dove, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 6/12, 2017, Pagina/e 1404-1408, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.7b00905

Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization

Autori: Ben Graham, Alice E. R. Fayter, Judith E. Houston, Rachel C. Evans, Matthew I. Gibson
Pubblicato in: Journal of the American Chemical Society, Numero 140/17, 2018, Pagina/e 5682-5685, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b02066

Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate–Carbohydrate Interactions

Autori: Sangho Won, Steven Hindmarsh, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 7/2, 2018, Pagina/e 178-183, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.7b00891

Permeable Protein-Loaded Polymersome Cascade Nanoreactors by Polymerization-Induced Self-Assembly

Autori: Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Alice Fayter, Matthew I. Gibson, Rachel K. O’Reilly
Pubblicato in: ACS Macro Letters, Numero 6/11, 2017, Pagina/e 1263-1267, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.7b00725

Comparison of photo- and thermally initiated polymerization-induced self-assembly: a lack of end group fidelity drives the formation of higher order morphologies

Autori: Lewis D. Blackman, Kay E. B. Doncom, Matthew I. Gibson, Rachel K. O'Reilly
Pubblicato in: Polymer Chemistry, Numero 8/18, 2017, Pagina/e 2860-2871, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/c7py00407a

Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility

Autori: Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Zachary H. Houston, Nicholas L. Fletcher, Kristofer J. Thurecht, Muhammad Hasan, Matthew I. Gibson, Rachel K. O’Reilly
Pubblicato in: ACS Central Science, Numero 4/6, 2018, Pagina/e 718-723, ISSN 2374-7943
Editore: ACS
DOI: 10.1021/acscentsci.8b00168

Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells

Autori: Daniel E. Mitchell, Joseph R. Lovett, Steven P. Armes, Matthew I. Gibson
Pubblicato in: Angewandte Chemie International Edition, Numero 55/8, 2016, Pagina/e 2801-2804, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201511454

Enhanced non-vitreous cryopreservation of immortalized and primary cells by ice-growth inhibiting polymers

Autori: Robert C. Deller, Jeffrey E. Pessin, Manu Vatish, Daniel A. Mitchell, Matthew I. Gibson
Pubblicato in: Biomater. Sci., Numero 4/7, 2016, Pagina/e 1079-1084, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/C6BM00129G

Influence of Block Copolymerization on the Antifreeze Protein Mimetic Ice Recrystallization Inhibition Activity of Poly(vinyl alcohol)

Autori: Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 17/9, 2016, Pagina/e 3033-3039, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.6b00915

Co-operative transitions of responsive-polymer coated gold nanoparticles; precision tuning and direct evidence for co-operative aggregation

Autori: Sangho Won, Daniel J. Phillips, Marc Walker, Matthew I. Gibson
Pubblicato in: J. Mater. Chem. B, Numero 4/34, 2016, Pagina/e 5673-5682, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/C6TB01336H

Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile

Autori: Lucienne Otten, Elizabeth Fullam, Matthew I. Gibson
Pubblicato in: Mol. BioSyst., Numero 12/2, 2016, Pagina/e 341-344, ISSN 1742-206X
Editore: Royal Society of Chemistry
DOI: 10.1039/C5MB00720H

Latent Ice Recrystallization Inhibition Activity in Nonantifreeze Proteins: Ca 2+ -Activated Plant Lectins and Cation-Activated Antimicrobial Peptides

Autori: Daniel E. Mitchell, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 16/10, 2015, Pagina/e 3411-3416, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.5b01118

One-step grafting of polymers to graphene oxide

Autori: Helen R. Thomas, Daniel J. Phillips, Neil R. Wilson, Matthew I. Gibson, Jonathan P. Rourke
Pubblicato in: Polym. Chem., Numero 6/48, 2015, Pagina/e 8270-8274, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/C5PY01358E

Probing the Biomimetic Ice Nucleation Inhibition Activity of Poly(vinyl alcohol) and Comparison to Synthetic and Biological Polymers

Autori: Thomas Congdon, Bethany T. Dean, James Kasperczak-Wright, Caroline I. Biggs, Rebecca Notman, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 16/9, 2015, Pagina/e 2820-2826, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.5b00774

Glycan heterogeneity on gold nanoparticles increases lectin discrimination capacity in label-free multiplexed bioassays

Autori: Lucienne Otten, Denise Vlachou, Sarah-Jane Richards, Matthew I. Gibson
Pubblicato in: The Analyst, Numero 141/14, 2016, Pagina/e 4305-4312, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/C6AN00549G

Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles

Autori: Laura E. Wilkins, Muhammad Hasan, Alice E. R. Fayter, Caroline Biggs, Marc Walker, Matthew I. Gibson
Pubblicato in: Polymer Chemistry, Numero 10/23, 2019, Pagina/e 2986-2990, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/c8py01719k

Ice-recrystallization inhibiting polymers protect proteins against freeze-stress and enable glycerol-free cryostorage

Autori: Daniel E. Mitchell, Alice E. R. Fayter, Robert C. Deller, Muhammad Hasan, Jose Gutierrez-Marcos, Matthew I. Gibson
Pubblicato in: Materials Horizons, Numero 6/2, 2019, Pagina/e 364-368, ISSN 2051-6347
Editore: Royal Society of Chemistry
DOI: 10.1039/c8mh00727f

Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers

Autori: Christopher Stubbs, Thomas R Congdon, Matthew I. Gibson
Pubblicato in: European Polymer Journal, Numero 110, 2019, Pagina/e 330-336, ISSN 0014-3057
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.eurpolymj.2018.11.047

Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active”?

Autori: Caroline I. Biggs, Christopher Stubbs, Ben Graham, Alice E. R. Fayter, Muhammad Hasan, Matthew I. Gibson
Pubblicato in: Macromolecular Bioscience, Numero Mater. Horiz., 2019,6, 364-368, 2019, Pagina/e 1900082, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201900082

Optimization and Stability of Cell-Polymer Hybrids Obtained by ‘Clicking’ Synthetic Polymers to Metabolically-Labeled Cell Surface Glycans

Autori: Ruben M. F. Tomas, Matthew I. Gibson
Pubblicato in: Biomacromolecules, 2019, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b00478

Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans

Autori: Ruben M. F. Tomás, Benjamin Martyn, Trisha L. Bailey, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 7/11, 2018, Pagina/e 1289-1294, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.8b00675

Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Microorganisms

Autori: Muhammad Hasan, Alice E. R. Fayter, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 19/8, 2018, Pagina/e 3371-3376, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b00660

Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors

Autori: Benjamin Martyn, Caroline I. Biggs, Matthew I. Gibson
Pubblicato in: Journal of Polymer Science Part A: Polymer Chemistry, Numero 57/1, 2018, Pagina/e 40-47, ISSN 0887-624X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/pola.29279

Sub-zero temperature mechanically stable low molecular weight hydrogels

Autori: Alice E. R. Fayter, Matthew I. Gibson, Emily R. Draper
Pubblicato in: Journal of Materials Chemistry B, Numero 6/44, 2018, Pagina/e 7274-7279, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/c8tb01668b

Multivalent Presentation of Ice Recrystallization Inhibiting Polymers on Nanoparticles Retains Activity

Autori: Christopher Stubbs, Laura E. Wilkins, Alice E. R Fayter, Marc Walker, Matthew I. Gibson
Pubblicato in: Langmuir, Numero 35/23, 2018, Pagina/e 7347-7353, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.8b01952

X-ray diffraction to probe the kinetics of ice recrystallization inhibition

Autori: Alice Fayter, Steven Huband, Matthew I. Gibson
Pubblicato in: The Analyst, Numero 145/10, 2020, Pagina/e 3666-3677, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/c9an02141h

Combinatorial Biomaterials Discovery Strategy to Identify New Macromolecular Cryoprotectants

Autori: Christopher Stubbs, Kathryn A. Murray, Toru Ishibe, Robert T. Mathers, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 9/2, 2020, Pagina/e 290-294, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.0c00044

Polyampholytes as Emerging Macromolecular Cryoprotectants

Autori: Christopher Stubbs, Trisha L. Bailey, Kathryn Murray, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 21/1, 2020, Pagina/e 7-17, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b01053

Ice recrystallisation inhibiting polymer nano-objects via saline-tolerant polymerisation-induced self-assembly

Autori: Panagiotis G. Georgiou, Ioanna Kontopoulou, Thomas R. Congdon, Matthew I. Gibson
Pubblicato in: Materials Horizons, Numero Mater. Horiz., 2020, Advance Article, 2020, ISSN 2051-6347
Editore: Royal Society of Chemistry
DOI: 10.1039/d0mh00354a

Post-thaw Culture and Measurement of Total Cell Recovery is Crucial in the Evaluation of New Macromolecular Cryoprotectants

Autori: Kathryn A Murray, Matthew I. Gibson
Pubblicato in: Biomacromolecules, 2020, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.0c00591

Non-peer reviewed articles (1)

Enhancement of Macromolecular Ice Recrystallization Inhibition Activity by Exploiting Depletion Forces

Autori: Toru Ishibe, Thomas Congdon, Christopher Stubbs, Muhammad Hasan, Gabriele C. Sosso, Matthew I. Gibson
Pubblicato in: ACS Macro Letters, Numero 8/8, 2019, Pagina/e 1063-1067, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.9b00386