Skip to main content

Monitor population immunity against vaccine preventable diseases

Cel

In the recent years an unprecedented effort has been made to increase the rates of childhood immunization in resource poor countries. This has translated into an increased number of children receiving vaccines and a parallel decrease in the rate of illnesses from vaccine preventable diseases. However, in some regions it has proven difficult to achieve optimal levels of immunization mainly because of issues concerning communication, management and poor utilization of resources. Recent studies have questioned the validity of available vaccine coverage data and the way they are collected. Currently, both the progress of the vaccination programs and indirectly the level of protection in a population are inferred on the basis of administrative records. This largely unverified information is also utilized as performance indicator to allocate funds from government and donor agencies. Such self-certification practice does not incentivize the optimization of resources while it has been increasingly questioned in terms of its validity and integrity. We propose to develop and validate an innovative technical solution based on an assay system that integrates multiplex capability and analytical performance, to simultaneously quantify antibody levels against the major vaccine components, with both automation and wireless connectivity to produce spatial-temporal co-ordinates of individual determinations. The multiplex capability will facilitate the analysis of cross coverage monitoring while generating reactivity profiles against the different vaccine components to discriminate vaccinated versus infected individuals. Spatial temporal co-ordinates of assay results will be used to generate interactive data sets for modeling changes in the age-specific risk of infection and the risk of outbreaks. The proposed system represents a formidable tool of unprecedented power to monitor the progress of different vaccination programs and experimentally validate record-based coverage data. The consortium proposes to develop an additional implementation of the technology, a low-cost portable microarray solution for healthcare point of testing (i.e. private doctors or pediatrician clinics, small district hospitals, rapid control of real vaccination profile in emergency situations) that converts the protein microarray for the determination of antibody protection against vaccines antigens into a lateral flow protein microarray, which can be coupled with software application for Smart phones to read the results.

Koordynator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Wkład UE netto
€ 328 500,00
Adres
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

Zobacz na mapie

Region
London Inner London — West Westminster
Rodzaj działalności
Higher or Secondary Education Establishments
Środki z innych źródeł
€ 328 500,00

Uczestnicy (5)

POLO D'INNOVAZIONE DI GENOMICA, GENETICA E BIOLOGIA SRL
Włochy
Wkład UE netto
€ 297 000,00
Adres
Via Fiorentina 1
53100 Siena

Zobacz na mapie

MŚP

Organizacja określiła się jako MŚP (firma z sektora małych i średnich przedsiębiorstw) w czasie podpisania umowy o grant.

Tak
Region
Centro (IT) Toscana Siena
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Środki z innych źródeł
€ 297 000,00
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Włochy
Wkład UE netto
€ 90 000,00
Adres
Piazzale Aldo Moro 5
00185 Roma

Zobacz na mapie

Region
Centro (IT) Lazio Roma
Rodzaj działalności
Higher or Secondary Education Establishments
Środki z innych źródeł
€ 90 000,00
UNIVERSITA DEGLI STUDI DI PERUGIA
Włochy
Wkład UE netto
€ 117 000,00
Adres
Piazza Dell Universita 1
06123 Perugia

Zobacz na mapie

Region
Centro (IT) Umbria Perugia
Rodzaj działalności
Higher or Secondary Education Establishments
Środki z innych źródeł
€ 117 000,00
MICROTEST MATRICES LTD

Zakończenie uczestnictwa

United Kingdom
Wkład UE netto
€ 0,00
Adres
Exhibition Road, Bessemer Building
SW7 2AZ London
MŚP

Organizacja określiła się jako MŚP (firma z sektora małych i średnich przedsiębiorstw) w czasie podpisania umowy o grant.

Tak
Region
London Inner London — West Westminster
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Środki z innych źródeł
€ 0,00
GENIALIS D.O.O
Słowenia
Wkład UE netto
€ 220 500,00
Adres
Koprska Ulica 72
1000 Ljubljana

Zobacz na mapie

MŚP

Organizacja określiła się jako MŚP (firma z sektora małych i średnich przedsiębiorstw) w czasie podpisania umowy o grant.

Tak
Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Środki z innych źródeł
€ 220 500,00

Partnerzy (1)

Partner

Organizacje partnerskie biorą udział w realizacji działania, jednak nie podpisują umowy o grant.

MINISTERE DE LA SANTE
Burkina Faso
Wkład UE netto
€ 0,00
Adres

7003 Ouagadougou

Zobacz na mapie

Rodzaj działalności
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Środki z innych źródeł
€ 0,00