During the action we developed several key technology platforms and conducted two sets of experiments. The technology platforms were necessary to precisely quantify the animal behaviour and assess, whether an improvement in performance is achieved during sensory substitution.
The first technology platform allowed rapid sensing of the animal position. This position was then converted into an acoustic or an optical signal signal played back to the animal (in the dark!). The animals learned to use this acoustic signal to improve their ability to cross an obstacle, when their whiskers were removed. Hence, sensory substitution could be established in this way in the mouse.
Next, we performed neural recordings from the auditory part of the brain of the mouse. These recordings could only be performed due to a second technology platform we developed, which allows to record from the behaving animal, while monitoring its behavior and whiskers at the same time. This new implant was also successfully developed and deployed in multiple animals.
Finally, we provided optical signals to the brain of mice whose brains were modified to be receptive to light. During this process we encountered technical difficulties, which we are currently working to resolve. These difficulties are related to the interaction of the light with scaring tissue, which reduced the light intensity below a level that can stimulate the brain. We are currently using improved implant designs and stronger light-sources to overcome the problem.
Throughout the research phase we have published 5 publications on related topics, and we currently preparing two additional publications, one on the sensory substitution results and one on the new technology platform. In addition we have presented our research at internal and external meetings and conferences.
