Digital Hybrid Breast PET/MRI for Enhanced Diagnosis of Breast Cancer

Risultati finali

Quantative reconstruction environment

Demosntration of the quantative reconstruction environment

Definition of biomarker signatures correlated to PET/MRI imaging

Report on the defintion of biomarker signatures correlated to PETMRI imaging

Definition of different types of immune infiltrates: immunoscore

Report on the defintion of the different types of immune infiltrates

Correlation of histopathological parameters, tumour micro-enviroment and PET/MRI imaging

Report on the correlation histopathologicalparameters tumour microenvironment and PETMRI imaging

Report on maintenance of website, updating with project news, results, success information

Report on maintenance of website updating with project news results success information

Project Website and CI

Creation of project website and corporate design for HYPMED Project

End user workshop

A workshop for end users will be organised

Pubblicazioni

Evaluation of the PETsys TOFPET2 ASIC in multi-channel coincidence experiments

Autori: Vanessa Nadig, David Schug, Bjoern Weissler, Volkmar Schulz
Pubblicato in: EJNMMI Physics, Numero 8, 2021, ISSN 2197-7364
Editore: Springer Nature
DOI: 10.1186/s40658-021-00370-x

AI-enhanced simultaneous multiparametric 18F-FDG PET/MRI for accurate breast cancer diagnosis

Autori: V. Romeo, P. Clauser, S. Rasul, P. Kapetas, P. Gibbs, P. A. T. Baltzer, M. Hacker, R. Woitek, T. H. Helbich, K. Pinker
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero 49, 2021, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-021-05492-z

108P Epigenetic regulation of the putative breast cancer metastasis suppressor gene SCN4B

Autori: L. Hilgers, A. Hartmann, P.A. Fasching, S. Villwock, L. Moll, S. Roger, R. Knüchel-Clarke, F. Steib, E.D. Dahl
Pubblicato in: Annals of Oncology, Numero 32, 2021, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.annonc.2021.03.122

Confounding factors in breast magnetic resonance fingerprinting: B1+, slice profile, and diffusion effects

Autori: Teresa Nolte, Hannah Scholten, Nicolas Gross-Weege, Thomas Amthor, Peter Koken, Mariya Doneva, Volkmar Schulz
Pubblicato in: Magnetic Resonance in Medicine, Numero Vol. 85 No. 4, 2020, Pagina/e 1865-1880, ISSN 1522-2594
Editore: International Society for Magnetic Resonance in Medicine
DOI: 10.1002/mrm.28545

Development of a Non-invasive Assessment of Hypoxia and Neovascularization with Magnetic Resonance Imaging in Benign and Malignant Breast Tumors: Initial Results

Autori: Andreas Stadlbauer, Max Zimmermann, Barbara Bennani-Baiti, Thomas H. Helbich, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Zsuzsanna Bago-Horvath, Katja Pinker
Pubblicato in: Molecular Imaging and Biology, 2018, ISSN 1536-1632
Editore: Elsevier BV
DOI: 10.1007/s11307-018-1298-4

Characterization methods for comprehensive evaluations of shielding materials used in an MRI

Autori: Nicolas Gross-Weege, Thomas Dey, Pierre Gebhardt, David Schug, Bjoern Weissler, Volkmar Schulz
Pubblicato in: Medical Physics, Numero 45/4, 2018, Pagina/e 1415-1424, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.12762

Multiparametric MRI model with dynamic contrast-enhanced and diffusion-weighted imaging enables breast cancer diagnosis with high accuracy

Autori: Michelle Zhang, Joao V. Horvat, Blanca Bernard-Davila, Maria Adele Marino, Doris Leithner, R. Elena Ochoa-Albiztegui, Thomas H. Helbich, Elizabeth A. Morris, Sunitha Thakur, Katja Pinker
Pubblicato in: Journal of Magnetic Resonance Imaging, Numero 49/3, 2019, Pagina/e 864-874, ISSN 1053-1807
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmri.26285

Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features

Autori: Wolf-Dieter Vogl, Katja Pinker, Thomas H. Helbich, Hubert Bickel, Günther Grabner, Wolfgang Bogner, Stephan Gruber, Zsuzsanna Bago-Horvath, Peter Dubsky, Georg Langs
Pubblicato in: European Radiology Experimental, Numero 3/1, 2019, ISSN 2509-9280
Editore: Springer Nature
DOI: 10.1186/s41747-019-0096-3

PIK3CA Mutational Status Is Associated with High Glycolytic Activity in ER+/HER2− Early Invasive Breast Cancer: a Molecular Imaging Study Using [18F]FDG PET/CT

Autori: Heinrich Magometschnigg, Katja Pinker, Thomas Helbich, Anita Brandstetter, Margaretha Rudas, Thomas Nakuz, Pascal Baltzer, Wolfgang Wadsak, Marcus Hacker, Michael Weber, Peter Dubsky, Martin Filipits
Pubblicato in: Molecular Imaging and Biology, Numero 21/5, 2019, Pagina/e 991-1002, ISSN 1536-1632
Editore: Elsevier BV
DOI: 10.1007/s11307-018-01308-z

Sequential [ 18 F]FDG-[ 18 F]FMISO PET and Multiparametric MRI at 3T for Insights into Breast Cancer Heterogeneity and Correlation with Patient Outcomes: First Clinical Experience

Autori: Piotr Andrzejewski, Georg Wengert, Thomas H. Helbich, Heinrich Magometschnigg, Dietmar Georg, Marcus Hacker, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Petra Georg, Wolfgang Wadsak, Katja Pinker
Pubblicato in: Contrast Media & Molecular Imaging, Numero 2019, 2019, Pagina/e 1-9, ISSN 1555-4309
Editore: John Wiley & Sons Inc.
DOI: 10.1155/2019/1307247

A multiparametric [18F]FDG PET/MRI diagnostic model including imaging biomarkers of the tumor and contralateral healthy breast tissue aids breast cancer diagnosis

Autori: Doris Leithner, Joao V. Horvat, Blanca Bernard-Davila, Thomas H. Helbich, R. Elena Ochoa-Albiztegui, Danny F. Martinez, Michelle Zhang, Sunitha B. Thakur, Georg J. Wengert, Anton Staudenherz, Maxine S. Jochelson, Elizabeth A. Morris, Pascal A. T. Baltzer, Paola Clauser, Panagiotis Kapetas, Katja Pinker
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero 46/9, 2019, Pagina/e 1878-1888, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-019-04331-6

Limited role of DWI with apparent diffusion coefficient mapping in breast lesions presenting as non-mass enhancement on dynamic contrast-enhanced MRI

Autori: Daly Avendano, Maria Adele Marino, Doris Leithner, Sunitha Thakur, Blanca Bernard-Davila, Danny F. Martinez, Thomas H. Helbich, Elizabeth A. Morris, Maxine S. Jochelson, Pascal A. T. Baltzer, Paola Clauser, Panagiotis Kapetas, Katja Pinker
Pubblicato in: Breast Cancer Research, Numero 21/1, 2019, ISSN 1465-542X
Editore: Springer Nature
DOI: 10.1186/s13058-019-1208-y

MR image corrections for PET-induced gradient distortions

Autori: Nicolas Gross-Weege, Teresa Nolte, Volkmar Schulz
Pubblicato in: Physics in Medicine & Biology, Numero 64/2, 2019, Pagina/e 02NT03, ISSN 1361-6560
Editore: IOP Publishing
DOI: 10.1088/1361-6560/aaf97a

Algorithms for joint activity–attenuation estimation from positron emission tomography scatter

Autori: Yannick Berker, Volkmar Schulz, Joel S. Karp
Pubblicato in: EJNMMI Physics, Numero 6/1, 2019, ISSN 2197-7364
Editore: Springer Open
DOI: 10.1186/s40658-019-0254-y

Spiral blurring correction with water–fat separation for magnetic resonance fingerprinting in the breast

Autori: Teresa Nolte, Nicolas Gross‐Weege, Mariya Doneva, Peter Koken, Aaldert Elevelt, Daniel Truhn, Christiane Kuhl, Volkmar Schulz
Pubblicato in: Magnetic Resonance in Medicine, Numero 83/4, 2019, Pagina/e 1192-1207, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27994

Automated Detection and Segmentation of Nonmass-Enhancing Breast Tumors with Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Autori: Ignacio Alvarez Illan, Javier Ramirez, J. M. Gorriz, Maria Adele Marino, Daly Avendano, Thomas Helbich, Pascal Baltzer, Katja Pinker, Anke Meyer-Baese
Pubblicato in: Contrast Media & Molecular Imaging, Numero 2018, 2018, Pagina/e 1-11, ISSN 1555-4309
Editore: John Wiley & Sons Inc.
DOI: 10.1155/2018/5308517

Crystal Delay and Time Walk Correction Methods for Coincidence Resolving Time Improvements of a Digital-Silicon-Photomultiplier-Based PET/MRI Insert

Autori: David Schug, Bjoern Weissler, Pierre Gebhardt, Volkmar Schulz
Pubblicato in: IEEE Transactions on Radiation and Plasma Medical Sciences, Numero 1/2, 2017, Pagina/e 178-190, ISSN 2469-7311
Editore: IEEE
DOI: 10.1109/TNS.2017.2654920

Intercrystal Scatter Rejection for Pixelated PET Detectors

Autori: Christian Ritzer, Patrick Hallen, David Schug, Volkmar Schulz
Pubblicato in: IEEE Transactions on Radiation and Plasma Medical Sciences, Numero 1/2, 2017, Pagina/e 191-200, ISSN 2469-7311
Editore: IEEE
DOI: 10.1109/TNS.2017.2664921

A Simultaneous Multiparametric 18F-FDG PET/MRI Radiomics Model for the Diagnosis of Triple Negative Breast Cancer

Autori: Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Pascal A. T. Baltzer, Sazan Rasul, Peter Gibbs, Marcus Hacker, Ramona Woitek, Katja Pinker, Thomas H. Helbich
Pubblicato in: Cancers, Numero 14, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14163944

Emerging Methods in Radiology

Autori: B. Theek, T. Nolte, D. Pantke, F. Schrank, F. Gremse, V. Schulz, F. Kiessling
Pubblicato in: Der Radiologe, Numero Vol. 60, 2020, Pagina/e 41-53, ISSN 1432-2102
Editore: Springer Medizin Verlag
DOI: 10.1007/s00117-020-00696-0

A dedicated PET insert for a 1.5T MR system for simultaneous breast PET/MRI

Autori: V Schulz, B Weissler, V Nadig, D Schug, P Gebhardt, C Kuhl, D Gareis, M Borgo, D Schaart
Pubblicato in: Nuklearmedizin, Numero Vol 60 No 2, 2021, Pagina/e 134-135, ISSN 2567-6407
Editore: Georg Thieme Verlag KG
DOI: 10.1055/s-0041-1726709

Hybrid total-body pet scanners—current status and future perspectives

Autori: V. Nadig, K. Herrmann, F.M. Mottaghy, V. Schulz
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero Vol. 49, 2021, Pagina/e 445-459, ISSN 1619-7089
Editore: Springer-Verlag GmbH
DOI: 10.1007/s00259-021-05536-4

The HYPMED PET/MRI Insert for Enhanced Diagnosis of Breast Cancer

Autori: S. Naunheim, Y. Kuhl, B. Weissler, D. Schug, H. Radermacher, F. Müller, V. Nadig, L. Yin, K. Krueger, P. Gebhardt, N. Gross-Weege, T. Nolte, E. Gegenmantel, M. Borgo, D. Gareis, T. Celik, S. Aussenhofer, A. Salomon, R. Bakker, V. Schulz
Pubblicato in: 2022
Editore: PSMR-TBP 2022 conference

Class II tumor suppressor genes in breast cancer can be classified according to intrinsic molecular subtypes and may be suitable for risk classification of ductal carcinoma in situ (DCIS)

Autori: E. Dahl
Pubblicato in: Numero not yet published, 2022
Editore: Deutsche Gesellschaft für Pathologie

Identifying novel class II tumor suppressor genes in breast cancer

Autori: N. Ortiz Brüchle, M. Onyuro, V.J. Dreyer, J.D.P. Engels, T. Longerich, T. Lüdde, S.H. Loosen, U. Neumann, L. Hilgers, S. Villwock, R. Knüchel-Clarke, F. Steib, E. Dahl
Pubblicato in: ViPa2021: Abstractband, 2021, Pagina/e 106
Editore: Deutsche Gesellschaft für Pathologie

Reducing Memory Requirements for Gradient Tree Boosting Models in FPGA Implementations for Position Estimation in PET Detectors

Autori: Karl Krueger, Lukas Johanns, Florian Mueller, Yannick Kuhl, Janko Lambertus, David Schug, Volkmar Schulz
Pubblicato in: 2022
Editore: PSMR-TBP 2022 conference

ptimization of FPGA-based gradient tree boosting models for position estimation in PET detectors

Autori: K. Krueger, F. Mueller, P. Gebhardt, B. Weissler, D. Schug, V. Schulz
Pubblicato in: 2021
Editore: IEEE NPSS

A High Count-Rate and Depth-of-Interaction Resolving Single-Layered One-Side Readout Pixelated Scintillator Crystal Array for PET Applications

Autori: J. M. C. Brown, S. E. Brunner, D. R. Schaart
Pubblicato in: IEEE Transactions on Radiation and Plasma Medical Sciences, Numero 4/3, 2020, Pagina/e 361-370, ISSN 2469-7311
Editore: IEEE
DOI: 10.1109/trpms.2019.2948106

Investigation of the Power Consumption of the PETsys TOFPET2 ASIC

Autori: Nadig, Vanessa; Weissler, Bjoern; Radermacher, Harald; Schulz, Volkmar; Schug, David
Pubblicato in: Numero 1, 2019
Editore: http://arxiv.org/abs/1908.05878

(Hybrid) SPECT and PET Technologies

Autori: Teresa Nolte, Nicolas Gross-Weege, Volkmar Schulz
Pubblicato in: Recent Results in Cancer Research, Numero Vol. 216, 2020, Pagina/e 111-133, ISSN 2197-6767
Editore: Springer-Verlag
DOI: 10.1007/978-3-030-42618-7_3

Diritti di proprietà intellettuale

HF-Empfangs-Spulenanordnung für kombinierte PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221037.0
Data: 2017-11-24

PET-Detektor für einen kombinierten PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221038.9
Data: 2017-11-24

Scintillator array for limited light sharing for depth-of-interaction determination

Numero candidatura/pubblicazione: NL 2020607
Data: 2018-03-16

PET-Detektor für einen kombinierten PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221038.9
Data: 2017-11-24

Scintillator array for limited light sharing for depth-of-interaction determination

Numero candidatura/pubblicazione: NL 2020607
Data: 2018-03-16

PET-Detektor für einen kombinierten PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221038.9
Data: 2017-11-24

HF-Empfangs-Spulenanordnung für kombinierte PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221037.0
Data: 2017-11-24

Scintillator array for limited light sharing for depth-of-interaction determination

Numero candidatura/pubblicazione: NL 2020607
Data: 2018-03-16

PET-Detektor für einen kombinierten PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221038.9
Data: 2017-11-24

HF-Empfangs-Spulenanordnung für kombinierte PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221037.0
Data: 2017-11-24

Scintillator array for limited light sharing for depth-of-interaction determination

Numero candidatura/pubblicazione: NL 2020607
Data: 2018-03-16

HF-Empfangs-Spulenanordnung für kombinierte PET/MRI-Scanner

Numero candidatura/pubblicazione: DE 102017221037.0
Data: 2017-11-24

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Risultati finali

Pubblicazioni

Diritti di proprietà intellettuale

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