Digital Hybrid Breast PET/MRI for Enhanced Diagnosis of Breast Cancer

Informacje na temat projektu

HYPMED

Identyfikator umowy o grant: 667211

DOI

10.3030/667211

Projekt został zamknięty

Data podpisania przez KE 9 Grudnia 2015

Data rozpoczęcia 1 Stycznia 2016

Data zakończenia 30 Czerwca 2022

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 5 861 957,50

Wkład UE

€ 5 861 957,50

Koordynowany przez

EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Demonstrators, pilots, prototypes (1)

Quantative reconstruction environment

Demosntration of the quantative reconstruction environment

Documents, reports (4)

Definition of biomarker signatures correlated to PET/MRI imaging

Report on the defintion of biomarker signatures correlated to PETMRI imaging

Definition of different types of immune infiltrates: immunoscore

Report on the defintion of the different types of immune infiltrates

Correlation of histopathological parameters, tumour micro-enviroment and PET/MRI imaging

Report on the correlation histopathologicalparameters tumour microenvironment and PETMRI imaging

Report on maintenance of website, updating with project news, results, success information

Report on maintenance of website updating with project news results success information

Websites, patent fillings, videos etc. (1)

Project Website and CI

Creation of project website and corporate design for HYPMED Project

Other (1)

End user workshop

A workshop for end users will be organised

Publikacje

Peer reviewed articles (22)

Evaluation of the PETsys TOFPET2 ASIC in multi-channel coincidence experiments

Autorzy: Vanessa Nadig, David Schug, Bjoern Weissler, Volkmar Schulz
Opublikowane w: EJNMMI Physics, Numer 8, 2021, ISSN 2197-7364
Wydawca: Springer Nature
DOI: 10.1186/s40658-021-00370-x

AI-enhanced simultaneous multiparametric 18F-FDG PET/MRI for accurate breast cancer diagnosis

Autorzy: V. Romeo, P. Clauser, S. Rasul, P. Kapetas, P. Gibbs, P. A. T. Baltzer, M. Hacker, R. Woitek, T. H. Helbich, K. Pinker
Opublikowane w: European Journal of Nuclear Medicine and Molecular Imaging, Numer 49, 2021, ISSN 1619-7070
Wydawca: Springer Verlag
DOI: 10.1007/s00259-021-05492-z

108P Epigenetic regulation of the putative breast cancer metastasis suppressor gene SCN4B

Autorzy: L. Hilgers, A. Hartmann, P.A. Fasching, S. Villwock, L. Moll, S. Roger, R. Knüchel-Clarke, F. Steib, E.D. Dahl
Opublikowane w: Annals of Oncology, Numer 32, 2021, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1016/j.annonc.2021.03.122

Confounding factors in breast magnetic resonance fingerprinting: B1+, slice profile, and diffusion effects

Autorzy: Teresa Nolte, Hannah Scholten, Nicolas Gross-Weege, Thomas Amthor, Peter Koken, Mariya Doneva, Volkmar Schulz
Opublikowane w: Magnetic Resonance in Medicine, Numer Vol. 85 No. 4, 2020, Strona(/y) 1865-1880, ISSN 1522-2594
Wydawca: International Society for Magnetic Resonance in Medicine
DOI: 10.1002/mrm.28545

Development of a Non-invasive Assessment of Hypoxia and Neovascularization with Magnetic Resonance Imaging in Benign and Malignant Breast Tumors: Initial Results

Autorzy: Andreas Stadlbauer, Max Zimmermann, Barbara Bennani-Baiti, Thomas H. Helbich, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Zsuzsanna Bago-Horvath, Katja Pinker
Opublikowane w: Molecular Imaging and Biology, 2018, ISSN 1536-1632
Wydawca: Elsevier BV
DOI: 10.1007/s11307-018-1298-4

Characterization methods for comprehensive evaluations of shielding materials used in an MRI

Autorzy: Nicolas Gross-Weege, Thomas Dey, Pierre Gebhardt, David Schug, Bjoern Weissler, Volkmar Schulz
Opublikowane w: Medical Physics, Numer 45/4, 2018, Strona(/y) 1415-1424, ISSN 0094-2405
Wydawca: American Association of Physicists in Medicine
DOI: 10.1002/mp.12762

Multiparametric MRI model with dynamic contrast-enhanced and diffusion-weighted imaging enables breast cancer diagnosis with high accuracy

Autorzy: Michelle Zhang, Joao V. Horvat, Blanca Bernard-Davila, Maria Adele Marino, Doris Leithner, R. Elena Ochoa-Albiztegui, Thomas H. Helbich, Elizabeth A. Morris, Sunitha Thakur, Katja Pinker
Opublikowane w: Journal of Magnetic Resonance Imaging, Numer 49/3, 2019, Strona(/y) 864-874, ISSN 1053-1807
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jmri.26285

Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features

Autorzy: Wolf-Dieter Vogl, Katja Pinker, Thomas H. Helbich, Hubert Bickel, Günther Grabner, Wolfgang Bogner, Stephan Gruber, Zsuzsanna Bago-Horvath, Peter Dubsky, Georg Langs
Opublikowane w: European Radiology Experimental, Numer 3/1, 2019, ISSN 2509-9280
Wydawca: Springer Nature
DOI: 10.1186/s41747-019-0096-3

PIK3CA Mutational Status Is Associated with High Glycolytic Activity in ER+/HER2− Early Invasive Breast Cancer: a Molecular Imaging Study Using [18F]FDG PET/CT

Autorzy: Heinrich Magometschnigg, Katja Pinker, Thomas Helbich, Anita Brandstetter, Margaretha Rudas, Thomas Nakuz, Pascal Baltzer, Wolfgang Wadsak, Marcus Hacker, Michael Weber, Peter Dubsky, Martin Filipits
Opublikowane w: Molecular Imaging and Biology, Numer 21/5, 2019, Strona(/y) 991-1002, ISSN 1536-1632
Wydawca: Elsevier BV
DOI: 10.1007/s11307-018-01308-z

Sequential [ 18 F]FDG-[ 18 F]FMISO PET and Multiparametric MRI at 3T for Insights into Breast Cancer Heterogeneity and Correlation with Patient Outcomes: First Clinical Experience

Autorzy: Piotr Andrzejewski, Georg Wengert, Thomas H. Helbich, Heinrich Magometschnigg, Dietmar Georg, Marcus Hacker, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Petra Georg, Wolfgang Wadsak, Katja Pinker
Opublikowane w: Contrast Media & Molecular Imaging, Numer 2019, 2019, Strona(/y) 1-9, ISSN 1555-4309
Wydawca: John Wiley & Sons Inc.
DOI: 10.1155/2019/1307247

A multiparametric [18F]FDG PET/MRI diagnostic model including imaging biomarkers of the tumor and contralateral healthy breast tissue aids breast cancer diagnosis

Autorzy: Doris Leithner, Joao V. Horvat, Blanca Bernard-Davila, Thomas H. Helbich, R. Elena Ochoa-Albiztegui, Danny F. Martinez, Michelle Zhang, Sunitha B. Thakur, Georg J. Wengert, Anton Staudenherz, Maxine S. Jochelson, Elizabeth A. Morris, Pascal A. T. Baltzer, Paola Clauser, Panagiotis Kapetas, Katja Pinker
Opublikowane w: European Journal of Nuclear Medicine and Molecular Imaging, Numer 46/9, 2019, Strona(/y) 1878-1888, ISSN 1619-7070
Wydawca: Springer Verlag
DOI: 10.1007/s00259-019-04331-6

Limited role of DWI with apparent diffusion coefficient mapping in breast lesions presenting as non-mass enhancement on dynamic contrast-enhanced MRI

Autorzy: Daly Avendano, Maria Adele Marino, Doris Leithner, Sunitha Thakur, Blanca Bernard-Davila, Danny F. Martinez, Thomas H. Helbich, Elizabeth A. Morris, Maxine S. Jochelson, Pascal A. T. Baltzer, Paola Clauser, Panagiotis Kapetas, Katja Pinker
Opublikowane w: Breast Cancer Research, Numer 21/1, 2019, ISSN 1465-542X
Wydawca: Springer Nature
DOI: 10.1186/s13058-019-1208-y

MR image corrections for PET-induced gradient distortions

Autorzy: Nicolas Gross-Weege, Teresa Nolte, Volkmar Schulz
Opublikowane w: Physics in Medicine & Biology, Numer 64/2, 2019, Strona(/y) 02NT03, ISSN 1361-6560
Wydawca: IOP Publishing
DOI: 10.1088/1361-6560/aaf97a

Algorithms for joint activity–attenuation estimation from positron emission tomography scatter

Autorzy: Yannick Berker, Volkmar Schulz, Joel S. Karp
Opublikowane w: EJNMMI Physics, Numer 6/1, 2019, ISSN 2197-7364
Wydawca: Springer Open
DOI: 10.1186/s40658-019-0254-y

Spiral blurring correction with water–fat separation for magnetic resonance fingerprinting in the breast

Autorzy: Teresa Nolte, Nicolas Gross‐Weege, Mariya Doneva, Peter Koken, Aaldert Elevelt, Daniel Truhn, Christiane Kuhl, Volkmar Schulz
Opublikowane w: Magnetic Resonance in Medicine, Numer 83/4, 2019, Strona(/y) 1192-1207, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27994

Automated Detection and Segmentation of Nonmass-Enhancing Breast Tumors with Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Autorzy: Ignacio Alvarez Illan, Javier Ramirez, J. M. Gorriz, Maria Adele Marino, Daly Avendano, Thomas Helbich, Pascal Baltzer, Katja Pinker, Anke Meyer-Baese
Opublikowane w: Contrast Media & Molecular Imaging, Numer 2018, 2018, Strona(/y) 1-11, ISSN 1555-4309
Wydawca: John Wiley & Sons Inc.
DOI: 10.1155/2018/5308517

Crystal Delay and Time Walk Correction Methods for Coincidence Resolving Time Improvements of a Digital-Silicon-Photomultiplier-Based PET/MRI Insert

Autorzy: David Schug, Bjoern Weissler, Pierre Gebhardt, Volkmar Schulz
Opublikowane w: IEEE Transactions on Radiation and Plasma Medical Sciences, Numer 1/2, 2017, Strona(/y) 178-190, ISSN 2469-7311
Wydawca: IEEE
DOI: 10.1109/TNS.2017.2654920

Intercrystal Scatter Rejection for Pixelated PET Detectors

Autorzy: Christian Ritzer, Patrick Hallen, David Schug, Volkmar Schulz
Opublikowane w: IEEE Transactions on Radiation and Plasma Medical Sciences, Numer 1/2, 2017, Strona(/y) 191-200, ISSN 2469-7311
Wydawca: IEEE
DOI: 10.1109/TNS.2017.2664921

A Simultaneous Multiparametric 18F-FDG PET/MRI Radiomics Model for the Diagnosis of Triple Negative Breast Cancer

Autorzy: Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Pascal A. T. Baltzer, Sazan Rasul, Peter Gibbs, Marcus Hacker, Ramona Woitek, Katja Pinker, Thomas H. Helbich
Opublikowane w: Cancers, Numer 14, 2022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14163944

Emerging Methods in Radiology

Autorzy: B. Theek, T. Nolte, D. Pantke, F. Schrank, F. Gremse, V. Schulz, F. Kiessling
Opublikowane w: Der Radiologe, Numer Vol. 60, 2020, Strona(/y) 41-53, ISSN 1432-2102
Wydawca: Springer Medizin Verlag
DOI: 10.1007/s00117-020-00696-0

A dedicated PET insert for a 1.5T MR system for simultaneous breast PET/MRI

Autorzy: V Schulz, B Weissler, V Nadig, D Schug, P Gebhardt, C Kuhl, D Gareis, M Borgo, D Schaart
Opublikowane w: Nuklearmedizin, Numer Vol 60 No 2, 2021, Strona(/y) 134-135, ISSN 2567-6407
Wydawca: Georg Thieme Verlag KG
DOI: 10.1055/s-0041-1726709

Hybrid total-body pet scanners—current status and future perspectives

Autorzy: V. Nadig, K. Herrmann, F.M. Mottaghy, V. Schulz
Opublikowane w: European Journal of Nuclear Medicine and Molecular Imaging, Numer Vol. 49, 2021, Strona(/y) 445-459, ISSN 1619-7089
Wydawca: Springer-Verlag GmbH
DOI: 10.1007/s00259-021-05536-4

Conference proceedings (5)

The HYPMED PET/MRI Insert for Enhanced Diagnosis of Breast Cancer

Autorzy: S. Naunheim, Y. Kuhl, B. Weissler, D. Schug, H. Radermacher, F. Müller, V. Nadig, L. Yin, K. Krueger, P. Gebhardt, N. Gross-Weege, T. Nolte, E. Gegenmantel, M. Borgo, D. Gareis, T. Celik, S. Aussenhofer, A. Salomon, R. Bakker, V. Schulz
Opublikowane w: 2022
Wydawca: PSMR-TBP 2022 conference

Class II tumor suppressor genes in breast cancer can be classified according to intrinsic molecular subtypes and may be suitable for risk classification of ductal carcinoma in situ (DCIS)

Autorzy: E. Dahl
Opublikowane w: Numer not yet published, 2022
Wydawca: Deutsche Gesellschaft für Pathologie

Identifying novel class II tumor suppressor genes in breast cancer

Autorzy: N. Ortiz Brüchle, M. Onyuro, V.J. Dreyer, J.D.P. Engels, T. Longerich, T. Lüdde, S.H. Loosen, U. Neumann, L. Hilgers, S. Villwock, R. Knüchel-Clarke, F. Steib, E. Dahl
Opublikowane w: ViPa2021: Abstractband, 2021, Strona(/y) 106
Wydawca: Deutsche Gesellschaft für Pathologie

Reducing Memory Requirements for Gradient Tree Boosting Models in FPGA Implementations for Position Estimation in PET Detectors

Autorzy: Karl Krueger, Lukas Johanns, Florian Mueller, Yannick Kuhl, Janko Lambertus, David Schug, Volkmar Schulz
Opublikowane w: 2022
Wydawca: PSMR-TBP 2022 conference

ptimization of FPGA-based gradient tree boosting models for position estimation in PET detectors

Autorzy: K. Krueger, F. Mueller, P. Gebhardt, B. Weissler, D. Schug, V. Schulz
Opublikowane w: 2021
Wydawca: IEEE NPSS

Non-peer reviewed articles (1)

A High Count-Rate and Depth-of-Interaction Resolving Single-Layered One-Side Readout Pixelated Scintillator Crystal Array for PET Applications

Autorzy: J. M. C. Brown, S. E. Brunner, D. R. Schaart
Opublikowane w: IEEE Transactions on Radiation and Plasma Medical Sciences, Numer 4/3, 2020, Strona(/y) 361-370, ISSN 2469-7311
Wydawca: IEEE
DOI: 10.1109/trpms.2019.2948106

Other (1)

Investigation of the Power Consumption of the PETsys TOFPET2 ASIC

Autorzy: Nadig, Vanessa; Weissler, Bjoern; Radermacher, Harald; Schulz, Volkmar; Schug, David
Opublikowane w: Numer 1, 2019
Wydawca: http://arxiv.org/abs/1908.05878

Monographic books (1)

(Hybrid) SPECT and PET Technologies

Autorzy: Teresa Nolte, Nicolas Gross-Weege, Volkmar Schulz
Opublikowane w: Recent Results in Cancer Research, Numer Vol. 216, 2020, Strona(/y) 111-133, ISSN 2197-6767
Wydawca: Springer-Verlag
DOI: 10.1007/978-3-030-42618-7_3

Prawa własności intelektualnej

Patent (3)

Scintillator array for limited light sharing for depth-of-interaction determination

Numer wniosku/publikacji: NL 2020607
Data: 2018-03-16
Wnioskodawca/wnioskodawcy: TECHNISCHE UNIVERSITEIT DELFT

HF-Empfangs-Spulenanordnung für kombinierte PET/MRI-Scanner

Numer wniosku/publikacji: DE 102017221037.0
Data: 2017-11-24
Wnioskodawca/wnioskodawcy: PHILIPS ELECTRONICS NEDERLAND BV

PET-Detektor für einen kombinierten PET/MRI-Scanner

Numer wniosku/publikacji: DE 102017221038.9
Data: 2017-11-24
Wnioskodawca/wnioskodawcy: PHILIPS ELECTRONICS NEDERLAND BV