PTX3 in Humoral Innate Immunity

Informacje na temat projektu

PHII

Identyfikator umowy o grant: 669415

DOI

10.3030/669415

Projekt został zamknięty

Data podpisania przez KE 3 Sierpnia 2015

Data rozpoczęcia 1 Września 2015

Data zakończenia 31 Sierpnia 2020

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 497 081,00

Wkład UE

€ 2 497 081,00

Koordynowany przez

HUMANITAS MIRASOLE SPA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (41)

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Autorzy: Alberto Mantovani, Charles A. Dinarello, Martina Molgora, Cecilia Garlanda
Opublikowane w: Immunity, Numer 50/4, 2019, Strona(/y) 778-795, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2019.03.012

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Autorzy: Isabelle Bally, Antonio Inforzato, Fabien Dalonneau, Matteo Stravalaci, Barbara Bottazzi, Christine Gaboriaud, Nicole M. Thielens
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00461

IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development

Autorzy: Federica Riva, Maurilio Ponzoni, Domenico Supino, Maria Teresa Sabrina Bertilaccio, Nadia Polentarutti, Matteo Massara, Fabio Pasqualini, Roberta Carriero, Anna Innocenzi, Achille Anselmo, Tania Veliz-Rodriguez, Giorgia Simonetti, Hans-Joachim Anders, Federico Caligaris-Cappio, Alberto Mantovani, Marta Muzio, Cecilia Garlanda
Opublikowane w: Cancer Immunology Research, Numer 7/6, 2019, Strona(/y) 874-885, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-18-0698

The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance

Autorzy: Annalisa Del Prete, Francesca Sozio, Tiziana Schioppa, Andrea Ponzetta, William Vermi, Stefano Calza, Mattia Bugatti, Valentina Salvi, Giovanni Bernardini, Federica Benvenuti, Annunciata Vecchi, Barbara Bottazzi, Alberto Mantovani, Silvano Sozzani
Opublikowane w: Cancer Immunology Research, Numer 7/11, 2019, Strona(/y) 1775-1788, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-19-0168

The inflammation - cancer connection

Autorzy: Alberto Mantovani
Opublikowane w: The FEBS Journal, Numer 285/4, 2018, Strona(/y) 638-640, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.14395

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8

Autorzy: Martina Molgora, Domenico Supino, Alberto Mantovani, Cecilia Garlanda
Opublikowane w: Immunological Reviews, Numer 281/1, 2018, Strona(/y) 233-247, ISSN 0105-2896
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imr.12609

Wandering pathways in the regulation of innate immunity and inflammation

Autorzy: Alberto Mantovani
Opublikowane w: Journal of Autoimmunity, Numer 85, 2017, Strona(/y) 1-5, ISSN 0896-8411
Wydawca: Academic Press
DOI: 10.1016/j.jaut.2017.10.007

PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer

Autorzy: Cecilia Garlanda, Barbara Bottazzi, Elena Magrini, Antonio Inforzato, Alberto Mantovani
Opublikowane w: Physiological Reviews, Numer 98/2, 2018, Strona(/y) 623-639, ISSN 0031-9333
Wydawca: American Physiological Society
DOI: 10.1152/physrev.00016.2017

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Autorzy: Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, Giovanni Bernardini, Elena Magrini, Francesca Gianni, Santiago Zelenay, Stipan Jonjić, Angela Santoni, Cecilia Garlanda, Alberto Mantovani
Opublikowane w: Nature, Numer 551/7678, 2017, Strona(/y) 110-114, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/NATURE24293

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

Autorzy: Alberto Mantovani, Isabella Barajon, Cecilia Garlanda
Opublikowane w: Immunological Reviews, Numer 281/1, 2018, Strona(/y) 57-61, ISSN 0105-2896
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imr.12614

Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer

Autorzy: Marcello Rubino, Paolo Kunderfranco, Gianluca Basso, Carolina Magdalen Greco, Fabio Pasqualini, Simone Serio, Massimo Roncalli, Luigi Laghi, Alberto Mantovani, Roberto Papait, Cecilia Garlanda
Opublikowane w: OncoImmunology, 2017, Strona(/y) e1333215, ISSN 2162-402X
Wydawca: Taylor & Francis Online
DOI: 10.1080/2162402X.2017.1333215

A guiding map for inflammation

Autorzy: Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath, Evangelos J Giamarellos-Bourboulis, Douglas Golenbock, Mark S Gresnigt, Michael T Heneka, Hal M Hoffman, Richard Hotchkiss, Leo A B Joosten, Daniel L Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H G Mills, Kristen L Nowak, Luke A O'Neill, Peter Pickkers, Tom van
Opublikowane w: Nature Immunology, Numer 18/8, 2017, Strona(/y) 826-831, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/NI.3790

Redundancy and robustness versus division of labour and specialization in innate immunity

Autorzy: Alberto Mantovani
Opublikowane w: Seminars in Immunology, Numer 36, 2018, Strona(/y) 28-30, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2017.12.006

The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair

Autorzy: Danka Grčević, Marina Sironi, Sonia Valentino, Livija Deban, Hrvoje Cvija, Antonio Inforzato, Nataša Kovačić, Vedran Katavić, Tomislav Kelava, Ivo Kalajzić, Alberto Mantovani, Barbara Bottazzi
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, Strona(/y) 1-18, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2018.00417

Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage

Autorzy: Andrea Doni, Giovanna D'Amico, Diego Morone, Alberto Mantovani, Cecilia Garlanda
Opublikowane w: Seminars in Cell & Developmental Biology, Numer 61, 2017, Strona(/y) 31-40, ISSN 1084-9521
Wydawca: Academic Press
DOI: 10.1016/j.semcdb.2016.07.026

The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage

Autorzy: Annalisa Del Prete, Laura Martínez-Muñoz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani
Opublikowane w: Blood, Numer 130/10, 2017, Strona(/y) 1223-1234, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2017-04-777680

"Optical <i>in vivo</i> imaging detection of preclinical models of gut tumors through the expression of Integrin αVβ3"

Autorzy: Giulia Marelli, Roberta Avigni, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Marco Erreni
Opublikowane w: Oncotarget, Numer 9/59, 2018, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.25826

Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation

Autorzy: Raffaella Bonecchi, Cecilia Garlanda, Alberto Mantovani, Federica Riva
Opublikowane w: Cytokine, Numer 87, 2016, Strona(/y) 37-45, ISSN 1043-4666
Wydawca: Academic Press
DOI: 10.1016/j.cyto.2016.06.023

Pentraxins in the activation and regulation of innate immunity

Autorzy: Kenji Daigo, Antonio Inforzato, Isabella Barajon, Cecilia Garlanda, Barbara Bottazzi, Seppo Meri, Alberto Mantovani
Opublikowane w: Immunological Reviews, Numer 274/1, 2016, Strona(/y) 202-217, ISSN 0105-2896
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imr.12476

Tumour-associated macrophages as treatment targets in oncology

Autorzy: Alberto Mantovani, Federica Marchesi, Alberto Malesci, Luigi Laghi, Paola Allavena
Opublikowane w: Nature Reviews Clinical Oncology, 2017, ISSN 1759-4774
Wydawca: Nature Publishing Group
DOI: 10.1038/nrclinonc.2016.217

Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial

Autorzy: Pietro Caironi, Serge Masson, Tommaso Mauri, Barbara Bottazzi, Roberto Leone, Michela Magnoli, Simona Barlera, Filippo Mamprin, Andrea Fedele, Alberto Mantovani, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Roberto Latini
Opublikowane w: European Journal of Clinical Investigation, Numer 47/1, 2017, Strona(/y) 73-83, ISSN 0014-2972
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/eci.12704

PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition

Autorzy: Cecilia Garlanda, Sebastien Jaillon, Andrea Doni, Barbara Bottazzi, Alberto Mantovani
Opublikowane w: Current Opinion in Immunology, Numer 38, 2016, Strona(/y) 39-44, ISSN 0952-7915
Wydawca: Elsevier BV
DOI: 10.1016/j.coi.2015.11.002

Fluid phase recognition molecules in neutrophil-dependent immune responses

Autorzy: Sébastien Jaillon, Andrea Ponzetta, Elena Magrini, Isabella Barajon, Marialuisa Barbagallo, Cecilia Garlanda, Alberto Mantovani
Opublikowane w: Seminars in Immunology, Numer 28/2, 2016, Strona(/y) 109-118, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2016.03.005

Clearance of Cell Remnants and Regeneration of Injured Muscle Depend on Soluble Pattern Recognition Receptor PTX3

Autorzy: Michela Vezzoli, Clara Sciorati
Opublikowane w: Molecular Medicine, Numer 22/1, 2016, Strona(/y) 1, ISSN 1076-1551
Wydawca: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2016.00002

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

Autorzy: Barbara Bottazzi, Antonio Inforzato, Massimo Messa, Marialuisa Barbagallo, Elena Magrini, Cecilia Garlanda, Alberto Mantovani
Opublikowane w: Journal of Hepatology, Numer 64/6, 2016, Strona(/y) 1416-1427, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2016.02.029

Innate immunity, hemostasis and matrix remodeling: PTX3 as a link

Autorzy: Andrea Doni, Cecilia Garlanda, Alberto Mantovani
Opublikowane w: Seminars in Immunology, Numer 28/6, 2016, Strona(/y) 570-577, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2016.10.012

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

Autorzy: Alejo Chorny, Sandra Casas-Recasens, Jordi Sintes, Meimei Shan, Nadia Polentarutti, Ramón García-Escudero, A. Cooper Walland, John R. Yeiser, Linda Cassis, Jorge Carrillo, Irene Puga, Cristina Cunha, Hélder Bastos, Fernando Rodrigues, João F. Lacerda, António Morais, Rebeca Dieguez-Gonzalez, Peter S. Heeger, Giovanni Salvatori, Agostinho Carvalho, Adolfo Garcia-Sastre, J. Magarian Blander, Al
Opublikowane w: The Journal of Experimental Medicine, Numer 213/10, 2016, Strona(/y) 2167-2185, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20150282

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation

Autorzy: F. Bonacina, S.S. Barbieri, L. Cutuli, P. Amadio, A. Doni, M. Sironi, S. Tartari, A. Mantovani, B. Bottazzi, C. Garlanda, E. Tremoli, A.L. Catapano, G.D. Norata
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 1862/6, 2016, Strona(/y) 1182-1190, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2016.03.007

The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Autorzy: Elena Magrini, Alberto Mantovani, Cecilia Garlanda
Opublikowane w: Trends in Molecular Medicine, Numer 22/6, 2016, Strona(/y) 497-510, ISSN 1471-4914
Wydawca: Elsevier BV
DOI: 10.1016/j.molmed.2016.04.007

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

Autorzy: Andrea Ponzetta, Roberta Carriero, Silvia Carnevale, Marialuisa Barbagallo, Martina Molgora, Chiara Perucchini, Elena Magrini, Francesca Gianni, Paolo Kunderfranco, Nadia Polentarutti, Fabio Pasqualini, Sabrina Di Marco, Domenico Supino, Clelia Peano, Ferdinando Cananzi, Piergiuseppe Colombo, Silvana Pilotti, Suliman Yousef Alomar, Eduardo Bonavita, Maria Rosaria Galdiero, Cecilia Garlanda, Albert
Opublikowane w: Cell, Numer 178/2, 2019, Strona(/y) 346-360.e24, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2019.05.047

Pentraxin 3 in Cardiovascular Disease

Autorzy: Giuseppe Ristagno, Francesca Fumagalli, Barbara Bottazzi, Alberto Mantovani, Davide Olivari, Deborah Novelli, Roberto Latini
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00823

Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity

Autorzy: Fabrizia Bonacina, Annalisa Moregola, Rémi Porte, Andrea Baragetti, Eduardo Bonavita, Alice Salatin, Liliana Grigore, Fabio Pellegatta, Martina Molgora, Marina Sironi, Elisa Barbati, Alberto Mantovani, Barbara Bottazzi, Alberico Luigi Catapano, Cecilia Garlanda, Giuseppe Danilo Norata
Opublikowane w: Cardiovascular Research, Numer 115/13, 2019, Strona(/y) 1861-1872, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvz068

The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer

Autorzy: Andrea Doni, Matteo Stravalaci, Antonio Inforzato, Elena Magrini, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00712

PTX3 Intercepts Vascular Inflammation in Systemic Immune-Mediated Diseases

Autorzy: Giuseppe A. Ramirez, Patrizia Rovere-Querini, Miriam Blasi, Silvia Sartorelli, Maria Chiara Di Chio, Mattia Baldini, Rebecca De Lorenzo, Enrica P. Bozzolo, Roberto Leone, Alberto Mantovani, Angelo A. Manfredi, Enrico Tombetti
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2019.01135

The yin-yang of the interaction between myelomonocytic cells and NK cells

Autorzy: Martina Molgora, Domenico Supino, Domenico Mavilio, Angela Santoni, Lorenzo Moretta, Alberto Mantovani, Cecilia Garlanda
Opublikowane w: Scandinavian Journal of Immunology, Numer 88/3, 2018, Strona(/y) e12705, ISSN 0300-9475
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/sji.12705

Innate immunity, inflammation and tumour progression: double‐edged swords

Autorzy: A. Mantovani, A. Ponzetta, A. Inforzato, S. Jaillon
Opublikowane w: Journal of Internal Medicine, Numer 285/5, 2019, Strona(/y) 524-532, ISSN 0954-6820
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/joim.12886

Editorial: The Role of Pentraxins: From Inflammation, Tissue Repair and Immunity to Biomarkers

Autorzy: Barbara Bottazzi, Cecilia Garlanda, Mauro Martins Teixeira
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2019.02817

Corrigendum to “Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation” [Biochim. Biophys. Acta, 1862 (2016) 1182–1190]

Autorzy: F. Bonacina, S.S. Barbieri, L. Cutuli, P. Amadi, A. Don, M. Sironi, S. Tartari, A. Mantovani, B. Bottazzi, C. Garlanda, E. Tremoli, A.L. Catapano, G.D. Norata
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 1865/1, 2019, Strona(/y) 262, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2018.09.017

The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis

Autorzy: Irene Mattiola, Federica Tomay, Maria De Pizzol, Rita Silva-Gomes, Benedetta Savino, Tamara Gulic, Andrea Doni, Silvia Lonardi, Marie Astrid Boutet, Alessandra Nerviani, Roberta Carriero, Martina Molgora, Matteo Stravalaci, Diego Morone, Irina N. Shalova, Yunquin Lee, Subhra K. Biswas, Giovanna Mantovani, Marina Sironi, Costantino Pitzalis, William Vermi, Barbara Bottazzi, Alberto Mantovani, Massi
Opublikowane w: Nature Immunology, Numer 20/8, 2019, Strona(/y) 1012-1022, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-019-0417-y

The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals

Autorzy: Nathália V. Batista, Marialuisa Barbagallo, Vivian L. S. Oliveira, Thiago Castro-Gomes, Rene D. R. Oliveira, Paulo Louzada-Junior, Geraldo R. C. Pinheiro, Alberto Mantovani, Mauro M. Teixeira, Cecilia Garlanda, Flávio A. Amaral
Opublikowane w: The Journal of Immunology, Numer 202/6, 2019, Strona(/y) 1807-1814, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1701531

Chronic inflammation in the etiology of disease across the life span

Autorzy: David Furman, Judith Campisi, Eric Verdin, Pedro Carrera-Bastos, Sasha Targ, Claudio Franceschi, Luigi Ferrucci, Derek W. Gilroy, Alessio Fasano, Gary W. Miller, Andrew H. Miller, Alberto Mantovani, Cornelia M. Weyand, Nir Barzilai, Jorg J. Goronzy, Thomas A. Rando, Rita B. Effros, Alejandro Lucia, Nicole Kleinstreuer, George M. Slavich
Opublikowane w: Nature Medicine, Numer 25/12, 2019, Strona(/y) 1822-1832, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-019-0675-0