Periodic Reporting for period 4 - EndoSubvert (Common mechanisms of host membrane trafficking subversion by intracellular pathogens to rupture bacterial containing vacuoles)
Okres sprawozdawczy: 2021-07-01 do 2022-12-31
2. We identified that macropinosomes are hijacked by bacterial pathogens to determine their precise intracellular localization. The bacteria are NOT taken up primarily within macropinsomes.
3. Our large volume correlative light electron microscopy pipelines are game changers in the field of cellular microbiology and cell biology.
4. Comparison of in-situ formed macropinosomes formed during infection with different pathogens showed their differential role in their intracellular niche formation.
5. Overall, the subverted host-pathways by invasive bacterial pathogens represent interesting targets for the development of antimicrobial strategies targeting the host.
6. The executed work through Endosubvert has resulted in more than 30 scientific publications until now and a patent application. The results have been presented at numerous scientific events.