Descrizione del progetto
Studiare la biologia del cancro attraverso la biologia dei sistemi
Comprendere la complessità dei sistemi e dei fenomeni biologici è un compito impegnativo, perché questi presentano numerosi componenti che interagiscono tra loro a più livelli. Anziché concentrarsi singolarmente su geni, proteine o percorsi, la biologia dei sistemi adotta un approccio olistico, considerando il sistema come una rete di elementi interconnessi. Il progetto CanPathPro, finanziato dall’UE, intende sviluppare una piattaforma di biologia dei sistemi per mettere alla prova alcune ipotesi sulla segnalazione del cancro. La piattaforma integrerà i dati provenienti da un sistema sperimentale murino, da operazioni di sequenziamento di nuova generazione e dalla proteomica, generando un modello completo di biologia dei sistemi. Secondo le attese, la piattaforma CanPathPro troverà applicazione nelle biotecnologie, nella medicina personalizzata e nello sviluppo di farmaci.
Obiettivo
Recent developments in omics technologies demand implementation of systems biology approaches to facilitate analysis and interpretation of the generated complex datasets.This is essential for biotechnological as well as preclinical and clinical applications. In comparison to previous approaches, most cancer relevant studies are confined to pattern recognition or at best modelling of single pathways, rather than the complex pathways and cross-talk determining cancer progression and drug response. Systematic tools that evaluate and validate personalised medicine approaches on a preclinical level are missing; an important prerequisite for translation into clinical practice. The overall objective of CanPathPro is to build and validate a new biotechnological application: a combined experimental and systems biology platform, which will be utilized in testing cancer signaling hypotheses in biomedical research and life sciences. Thus, the proposed project will focus on developing and refining bioinformatic and experimental tools for the evaluation of systems biology modelling predictions. Components comprise a highly controlled mouse experimental system, NGS, a quantitative proteomics based read-out of changes in pathway signalling and an integrative systems biology model for data integration. Testable hypotheses about biological systems will be generated and experimentally validated. The developed system tools will be made available to researchers, SMEs and industry for practical applications. Following this project, a commercial platform for interpretation and analysis of complex omics data and for deriving and testing new hypotheses will be set up by the participating companies and academic partners. CanPathPro will enhance the competitive potential of the SMEs involved expanding in the field of biotechnology, personalised medicine and drug development and also provide new opportunities for other SMEs working in the field of bioinformatics and biomedical applications.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesclinical medicineoncologylung cancer
- medical and health scienceshealth sciencespersonalized medicine
- natural sciencescomputer and information sciencesartificial intelligencepattern recognition
- natural sciencesmathematicsapplied mathematicsmathematical model
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-LEIT-BIO-2015-1
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
12489 Berlin
Germania
L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.