Targeting Innate Lymphoid Cells

Informacje na temat projektu

TILC

Identyfikator umowy o grant: 694502

DOI

10.3030/694502

Projekt został zamknięty

Data podpisania przez KE 21 Listopada 2016

Data rozpoczęcia 1 Stycznia 2017

Data zakończenia 31 Grudnia 2022

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 500 000,00

Wkład UE

€ 2 500 000,00

Koordynowany przez

UNIVERSITE D'AIX MARSEILLE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (36)

ILC3s control splenic cDC homeostasis via lymphotoxin signaling

Autorzy: Matthias Vanderkerken, Antonio P. Baptista , Marco De Giovanni , Satoshi Fukuyama, Robin Browaeys , Charlotte L.SCott, Paula S. Norris , Gerard Eberl , James P. Di Santo , Eric Vivier ,Yvan Saeys ,Hamida Hammad , Jason G. Cyster , Carl F. Ware , Alexei V. Tumanov ,Carl De Trez , Bart N. Lambrecht
Opublikowane w: Journal of Experimental Medecine, 2021, ISSN 1540-9538
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20190835

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Autorzy: Julien Carvelli, Olivier Demaria, Frédéric Vély, Luciana Batista, Nassima Chouaki Benmansour, Joanna Fares, Sabrina Carpentier, Marie-Laure Thibult, Ariane Morel, Romain Remark, Pascale André, Agnès Represa, Christelle Piperoglou, Pierre Yves Cordier, Erwan Le Dault, Christophe Guervilly, Pierre Simeone, Marc Gainnier, Yannis Morel, Mikael Ebbo, Nicolas Schleinitz, Eric Vivier
Opublikowane w: Nature, Numer 588/7836, 2020, Strona(/y) 146-150, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-020-2600-6

Tissue-specific transcriptional profiles and heterogeneity of natural killer cells and group 1 innate lymphoid cells

Autorzy: Noella Lopes, Justine Galluso, Bertrand Escaliere, Sabrina Carpentier, Yann M. Kerdiles, Eric Vivier
Opublikowane w: Cell Reports Medecine, 2022, ISSN 2666-3791
Wydawca: Cell Press
DOI: 10.1016/j.xcrm.2022.100812

Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis

Autorzy: Madison R. Mack, Jonathan R. Brestoff, Melissa M. Berrien-Elliott, Anna M. Trier, Ting-Lin B. Yang, Matthew McCullen, Patrick L. Collins, Haixia Niu, Nancy D. Bodet, Julia A. Wagner, Eugene Park, Amy Z. Xu, Fang Wang, Rebecca Chibnall, M. Laurin Council, Carrie Heffington, Friederike Kreisel, David J. Margolis, David Sheinbein, Paola Lovato, Eric Vivier, Marina Cella, Marco Colonna, Wayne M. Yokoy
Opublikowane w: Science Translational Medicine, Numer 12/532, 2020, Strona(/y) eaay1005, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay1005

Maternal diesel particle exposure promotes offspring asthma through NK cell–derived granzyme B

Autorzy: Qian Qian, Bidisha Paul Chowdhury, Zehua Sun, Jerica Lenberg, Rafeul Alam, Eric Vivier, Magdalena M. Gorska
Opublikowane w: Journal of Clinical Investigation, 2020, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci130324

Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

Autorzy: Adeline Crinier, Pierre-Yves Dumas, Bertrand Escalière, Christelle Piperoglou, Laurine Gil, Arnaud Villacreces, Frédéric Vély, Zoran Ivanovic, Pierre Milpied, Émilie Narni-Mancinelli, Éric Vivier
Opublikowane w: Cellular & Molecular Immunology, Numer 18/5, 2021, Strona(/y) 1290-1304, ISSN 1672-7681
Wydawca: Nature Publishing Group
DOI: 10.1038/s41423-020-00574-8

Boosting Cytotoxic Antibodies against Cancer

Autorzy: Laurent Gauthier, Eric Vivier
Opublikowane w: Cell, Numer 180/5, 2020, Strona(/y) 822-824, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2020.02.025

Phase I Trial of Prophylactic Donor-Derived IL-2-Activated NK Cell Infusion after Allogeneic Hematopoietic Stem Cell Transplantation from a Matched Sibling Donor

Autorzy: Raynier Devillier ,Boris Calmels ,Sophie Guia , Mohammed Taha , Cyril Fauriat , Bechara Mfarrej , Geoffroy Venton , Eric Vivier , Daniel Olive , Christian Chabannon , Didier Blaise ,and Sophie Ugolini
Opublikowane w: Cancers, 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13112673

Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Autorzy: Pierre-Louis Bernard,Rebecca Delconte , Sonia Pastor,1 Vladimir Laletin ,Cathy Costa Da Silva,Armelle Goubard, Emmanuelle Josselin, Rémy Castellano ,Adrien Krug, Julien Vernerey , Raynier Devillier ,Daniel Olive , Els Verhoeyen , Eric Vivier , Nicholas D Huntington , Jacques Nunes ,Geoffrey Guittard
Opublikowane w: Journal of ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Wydawca: BMJ Journals
DOI: 10.1136/jitc-2021-004244

Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells

Autorzy: Garvin Dodard, Angela Tata, Timothy K. Erick, Diego Jaime, S.M. Shahjahan Miah, Linda Quatrini, Bertrand Escalière, Sophie Ugolini, Eric Vivier, Laurent Brossay
Opublikowane w: Cell Reports, Numer 32/1, 2020, Strona(/y) 107855, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.107855

Role of NKp46 + natural killer cells in house dust mite‐driven asthma

Autorzy: Eline Haspeslagh, Mary J van Helden, Kim Deswarte, Sofie De Prijck, Justine van Moorleghem, Louis Boon, Hamida Hammad, Eric Vivier, Bart N Lambrecht
Opublikowane w: EMBO Molecular Medicine, Numer 10/4, 2018, Strona(/y) e8657, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201708657

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo

Autorzy: Giorgia Rota, Charlène Niogret, Anh Thu Dang, Cristina Ramon Barros, Nicolas Pierre Fonta, Francesca Alfei, Leonor Morgado, Dietmar Zehn, Walter Birchmeier, Eric Vivier, Greta Guarda
Opublikowane w: Cell Reports, Numer 23/1, 2018, Strona(/y) 39-49, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2018.03.026

Innate Lymphoid Cells: 10 Years On

Autorzy: Eric Vivier, David Artis, Marco Colonna, Andreas Diefenbach, James P. Di Santo, Gérard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N.J. McKenzie, Reina E. Mebius, Fiona Powrie, Hergen Spits
Opublikowane w: Cell, Numer 174/5, 2018, Strona(/y) 1054-1066, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2018.07.017

Complement factor P is a ligand for the natural killer cell–activating receptor NKp46

Autorzy: Emilie Narni-Mancinelli, Laurent Gauthier, Myriam Baratin, Sophie Guia, Aurore Fenis, Ala-Eddine Deghmane, Benjamin Rossi, Patrick Fourquet, Bertrand Escalière, Yann M. Kerdiles, Sophie Ugolini, Muhamed-Kheir Taha, Eric Vivier
Opublikowane w: Science Immunology, Numer 2/10, 2017, Strona(/y) eaam9628, ISSN 2470-9468
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aam9628

Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells

Autorzy: Linda Quatrini, Elisabeth Wieduwild, Sophie Guia, Claire Bernat, Nicolas Glaichenhaus, Eric Vivier, Sophie Ugolini
Opublikowane w: The Journal of Experimental Medicine, Numer 214/12, 2017, Strona(/y) 3531-3541, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20171048

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Autorzy: Charlène Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-09431-3

Helper-like innate lymphoid cells and cancer immunotherapy

Autorzy: Adeline Crinier, Eric Vivier, Mathieu Bléry
Opublikowane w: Seminars in Immunology, 2019, Strona(/y) 101274, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2019.04.002

Neuroendocrine regulation of innate lymphoid cells

Autorzy: Linda Quatrini, Eric Vivier, Sophie Ugolini
Opublikowane w: Immunological Reviews, Numer 286/1, 2018, Strona(/y) 120-136, ISSN 0105-2896
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imr.12707

High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

Autorzy: Adeline Crinier, Pierre Milpied, Bertrand Escalière, Christelle Piperoglou, Justine Galluso, Anaïs Balsamo, Lionel Spinelli, Inaki Cervera-Marzal, Mikaël Ebbo, Mathilde Girard-Madoux, Sébastien Jaeger, Emilie Bollon, Sami Hamed, Jean Hardwigsen, Sophie Ugolini, Frédéric Vély, Emilie Narni-Mancinelli, Eric Vivier
Opublikowane w: Immunity, Numer 49/5, 2018, Strona(/y) 971-986.e5, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2018.09.009

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

Autorzy: Pascale André, Caroline Denis, Caroline Soulas, Clarisse Bourbon-Caillet, Julie Lopez, Thomas Arnoux, Mathieu Bléry, Cécile Bonnafous, Laurent Gauthier, Ariane Morel, Benjamin Rossi, Romain Remark, Violette Breso, Elodie Bonnet, Guillaume Habif, Sophie Guia, Ana Ines Lalanne, Caroline Hoffmann, Olivier Lantz, Jérôme Fayette, Agnès Boyer-Chammard, Robert Zerbib, Pierre Dodion, Hormas Ghadiall
Opublikowane w: Cell, Numer 175/7, 2018, Strona(/y) 1731-1743.e13, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2018.10.014

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

Autorzy: Ivan Perrot, Henri-Alexandre Michaud, Marc Giraudon-Paoli, Séverine Augier, Aurélie Docquier, Laurent Gros, Rachel Courtois, Cécile Déjou, Diana Jecko, Ondine Becquart, Hélène Rispaud-Blanc, Laurent Gauthier, Benjamin Rossi, Stéphanie Chanteux, Nicolas Gourdin, Beatrice Amigues, Alain Roussel, Armand Bensussan, Jean-François Eliaou, Jérémy Bastid, François Romagné, Yannis Morel, Emilie
Opublikowane w: Cell Reports, Numer 27/8, 2019, Strona(/y) 2411-2425.e9, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.04.091

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Autorzy: Laurent Gauthier, Ariane Morel, Nadia Anceriz, Benjamin Rossi, Audrey Blanchard-Alvarez, Gwendoline Grondin, Sylvia Trichard, Cédric Cesari, Melody Sapet, Frédéric Bosco, Hélène Rispaud-Blanc, Franceline Guillot, Stéphanie Cornen, Alain Roussel, Béatrice Amigues, Guillaume Habif, Flavien Caraguel, Sandrine Arrufat, Romain Remark, François Romagné, Yannis Morel, Emilie Narni-Mancinelli, Er
Opublikowane w: Cell, Numer 177/7, 2019, Strona(/y) 1701-1713.e16, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2019.04.041

A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets

Autorzy: Francisca F. Almeida, Sara Tognarelli, Antoine Marçais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zöller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G.
Opublikowane w: OncoImmunology, Numer 7/10, 2018, Strona(/y) e1475875, ISSN 2162-402X
Wydawca: Taylor & Francis
DOI: 10.1080/2162402x.2018.1475875

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

Autorzy: Linda Quatrini, Elisabeth Wieduwild, Bertrand Escaliere, Jessica Filtjens, Lionel Chasson, Caroline Laprie, Eric Vivier, Sophie Ugolini
Opublikowane w: Nature Immunology, Numer 19/9, 2018, Strona(/y) 954-962, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-018-0185-0

Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection

Autorzy: Susanna S Ng, Fernando Souza-Fonseca-Guimaraes, Fabian de Labastida Rivera, Fiona H Amante, Rajiv Kumar, Yulong Gao, Meru Sheel, Lynette Beattie, Marcela Montes de Oca, Camille Guillerey, Chelsea L Edwards, Rebecca J Faleiro, Teija Frame, Patrick T Bunn, Eric Vivier, Dale I Godfrey, Daniel G Pellicci, J Alejandro Lopez, Katherine T Andrews, Nicholas D Huntington, Mark J Smyth, James McCarthy, Chri
Opublikowane w: Clinical & Translational Immunology, Numer 7/1, 2018, Strona(/y) e1003, ISSN 2050-0068
Wydawca: Wiley
DOI: 10.1002/cti2.1003

Inherited IL-18BP deficiency in human fulminant viral hepatitis

Autorzy: Serkan Belkaya, Eleftherios Michailidis, Cecilia B. Korol, Mohammad Kabbani, Aurélie Cobat, Paul Bastard, Yoon Seung Lee, Nicholas Hernandez, Scott Drutman, Ype P. de Jong, Eric Vivier, Julie Bruneau, Vivien Béziat, Bertrand Boisson, Lazaro Lorenzo-Diaz, Soraya Boucherit, Mylène Sebagh, Emmanuel Jacquemin, Jean-François Emile, Laurent Abel, Charles M. Rice, Emmanuelle Jouanguy, Jean-Laurent Ca
Opublikowane w: The Journal of Experimental Medicine, Numer 216/8, 2019, Strona(/y) 1777-1790, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20190669

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Autorzy: Jai Rautela, Laura F. Dagley, Carolina C. de Oliveira, Iona S. Schuster, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Joseph Cursons, Robert Hennessy, Dana S. Hutchinson, Craig Harrison, Badia Kita, Eric Vivier, Andrew I. Webb, Mariapia A. Degli-Esposti, Melissa J. Davis, Nicholas D. Huntington, Fernando Souza-Fonseca-Guimaraes
Opublikowane w: Science Signaling, Numer 12/596, 2019, Strona(/y) eaat7527, ISSN 1937-9145
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aat7527

Monalizumab: inhibiting the novel immune checkpoint NKG2A

Autorzy: Thorbald van Hall, Pascale André, Amir Horowitz, Dan Fu Ruan, Linda Borst, Robert Zerbib, Emilie Narni-Mancinelli, Sjoerd H. van der Burg, Eric Vivier
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 7/1, 2019, ISSN 2051-1426
Wydawca: BMJ Publishing Group Ltd & Society for Immunotherapy of Cancer
DOI: 10.1186/s40425-019-0761-3

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Autorzy: Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
Opublikowane w: Journal of Experimental Medicine, Numer 216/9, 2019, Strona(/y) 2010-2023, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20182164

Nouvelles frontières de la lutte contre le cancer

Autorzy: Laura Chiossone, Eric Vivier
Opublikowane w: Biologie Aujourd'hui, Numer 212/3-4, 2018, Strona(/y) 61-67, ISSN 2105-0678
Wydawca: Societe de Biologie
DOI: 10.1051/jbio/2019011

Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers

Autorzy: Angela Tata, Garvin Dodard,Céline Fugère, Corinne Leget,Mélody Ors, Benjamin Rossi, Eric Vivier,and Laurent Brossay
Opublikowane w: OncoImmunology, 2021, ISSN 2162-4011
Wydawca: Landes Bioscience
DOI: 10.1080/2162402x.2021.1933808

Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia

Autorzy: Natalia Colomar-Carando , Laurent Gauthier , Pietro Merli , Fabrizio Loiacono , Paolo Canevali , Michela Falco , Federica Galaverna , Benjamin Rossi , Frédéric Bosco , Mélody Caratini , Maria Cristina Mingari , Franco Locatelli, Eric Vivier , Raffaella Meazza , Daniela Pende
Opublikowane w: Cancer Immunology Research, 2022, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0843

Role Of The Itam-Bearing Receptors Expressed By Natural Killer Cells In Cancer

Autorzy: Hakim Medjouel Khlifi, Sophie Guia, Eric Vivier, Emilie Narni-Mancinelli.
Opublikowane w: Frontiers in Immunology, 2022, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2022.898745

Immuno-Oncology beyond TILs: Unleashing TILCs

Autorzy: Olivier Demaria, Eric Vivier
Opublikowane w: Cancer Cell, Numer 37/4, 2020, Strona(/y) 428-430, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2020.03.021

Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19

Autorzy: Olivier Demaria, Julien Carvelli, Luciana Batista, Marie-Laure Thibult, Ariane Morel, Pascale André, Yannis Morel, Frederic Vély, Eric Vivier
Opublikowane w: Cellular & Molecular Immunology, Numer 17/9, 2020, Strona(/y) 995-997, ISSN 1672-7681
Wydawca: Nature Publishing Group
DOI: 10.1038/s41423-020-0493-9

c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

Autorzy: Ute Bank, Katrin Deiser, Carlos Plaza-Sirvent, Lisa Osbelt, Amelie Witte, Laura Knop, Rebecca Labrenz, Robert Jänsch, Felix Richter, Aindrila Biswas, Ana C. Zenclussen, Eric Vivier, Chiara Romagnani, Anja A. Kühl, Ildiko R. Dunay, Till Strowig, Ingo Schmitz, Thomas Schüler
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-14782-3