Cel Replacement of petrochemistry-based transport fuels and bulk chemicals by industrial biotechnology requires cost-efficient microbial processes, whose feedstock-to-product conversion efficiencies approach theoretical maxima. For many products, such high efficiencies require anaerobic processes and, consequently, industrial microorganisms capable of robust anaerobic growth. Yeasts are robust micro-organisms but, with the notable exception of Saccharomyces species, they share an important limitation with most other eukaryotes: they cannot grow anaerobically.Even Saccharomyces cerevisiae, the yeast responsible for industrial fuel ethanol production in large-scale anaerobic processes, requires sterols and unsaturated fatty acids (UFAs) for anaerobic growth. Depletion of these anaerobic growth factors deteriorates its fermentation performance. Several ethanol-producing, non-Saccharomyces species have highly attractive properties for industrial application, including a much higher thermotolerance and broader substrate range than S. cerevisiae. However, in addition to sterol and UFA synthesis, these yeasts have other, unidentified oxygen requirements. Unless the molecular basis for these oxygen requirements is elucidated, their huge potential for sustainable production of biofuels and chemicals cannot be accessed by industry.This proposal addresses the fundamental scientific question why so many yeasts that can ferment sugars to ethanol are nevertheless unable to grow anaerobically. Moreover, by enabling anaerobic growth of non-Saccharomyces yeasts, it aims to build yeast platforms with unprecedented advantages for industrial biotechnology. The proposed innovative approach to these challenges integrates cutting-edge experimental techniques in quantitative physiology and comparative genomics of yeasts and anaerobic fungi, computational modelling, and synthetic-biology-assisted metabolic engineering of different yeast species. Dziedzina nauki natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural scienceschemical sciencesorganic chemistryalcoholsengineering and technologyindustrial biotechnologybioprocessing technologiesfermentation Słowa kluczowe Microbial physiology metabolic engineering biofuels yeast anaerobic processes Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-ADG-2015 - ERC Advanced Grant Zaproszenie do składania wniosków ERC-2015-AdG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-ADG - Advanced Grant Instytucja przyjmująca TECHNISCHE UNIVERSITEIT DELFT Wkład UE netto € 2 498 150,00 Adres STEVINWEG 1 2628 CN Delft Niderlandy Zobacz na mapie Region West-Nederland Zuid-Holland Delft en Westland Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 2 498 150,00 Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko TECHNISCHE UNIVERSITEIT DELFT Niderlandy Wkład UE netto € 2 498 150,00 Adres STEVINWEG 1 2628 CN Delft Zobacz na mapie Region West-Nederland Zuid-Holland Delft en Westland Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 2 498 150,00
