Cel The main objective of the proposed project is the establishment of a generically-applicable new therapeutic molecule format, which will be referred as “bicyclic hetero peptidimer”. We propose linking two bicyclic peptides that bind to the same target but in different locations to generate an antagonist with high affinity and activity. This idea borrows from antibody therapeutics that typically have two arms that can bind to the target, increasing local concentration and improving the overall affinity of the therapeutic. In a second step, we will tether our active bicyclic hetero peptidimer to a known albumin-binding peptide to improve plasma half-life. This has previously been shown to increase the half-life of bicyclic peptides by nearly 50-fold in mice.In the proposed project we will use the new peptide format for the development of picomolar FXII inhibitors. Uncontrolled FXII activity is the cause for the severe disease hereditary angioedema (HEA), where currently no satisfactory therapeutic options are available. This general concept is in no way limited to any particular target, and has the potential to be generally applicable to any peptide-based therapeutics to increase both affinity as well as half-life, two of the major drawbacks to current peptide-based treatment strategies. Dziedzina nauki medical and health sciencesclinical medicinesurgerynatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesclinical medicinehematologynatural scienceschemical sciencesorganic chemistryamines Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2015 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Wkład UE netto € 131 564,70 Adres BATIMENT CE 3316 STATION 1 1015 Lausanne Szwajcaria Zobacz na mapie Region Schweiz/Suisse/Svizzera Région lémanique Vaud Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 131 564,70