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Beta-cell inflammation and dysfunction induced by bacterial translocation

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Type 2 diabetes (T2D) has risen to epidemic proportions resulting in major morbidity and mortality. In addition to insulin
resistance (i.e. impaired insulin action), impaired function and destruction of the insulin-producing beta cells form the direct
cause for hyperglycemia and T2D, and causes the progressive course of disease. As such, due to continuous beta-cell
destruction, many patients require treatment with exogenous insulin therapy. Clearly, therapies that may halt or reverse this
detrimental process are warranted.
An inflammatory process in islets of Langerhans, with infiltration of immune cells and a central role for toll-like receptors
(TLR), is present in T2D, however, the primary trigger for this inflammatory response remains unknown. Recently, (diet-induced)
alterations in intestinal microbiota composition were shown to associate with T2D. In addition, T2D patients have
increased translocation of detrimental bacteria (‘leaky gut’), previously shown to induce adipose tissue inflammation and
dysfunction.
Recently, I hypothesized that increased bacterial translocation to the pancreas induces inflammation and beta-cell
dysfunction in T2D through TLR related mechanisms. I addressed this hypothesis first by identifying translocated microorganism
DNA in pancreatic tissue harvested during pancreatectomy in patients with and without T2D. In pilot data, I have
demonstrated increased bacterial load in patients with T2D as compared to control patients. The involved micro organisms
with highest pathogenicity will be (an)aerobically cultured and subsequently used in gavage studies in a obese mouse model with or without a knockout for TRL4 to study their effects effects on beta-cell function, glucose metabolism and pancreas inflammation.

Dziedzina nauki

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Zaproszenie do składania wniosków

H2020-MSCA-IF-2015

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System finansowania

MSCA-IF-GF - Global Fellowships

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STICHTING VUMC
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€ 167 610,60
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De boelelaan 1117
1081 HV Amsterdam
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West-Nederland Noord-Holland Groot-Amsterdam
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Data podpisania przez KE 10 Maja 2016
Ostatnia aktualizacja: 15 Sierpnia 2022

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Permalink: https://cordis.europa.eu/project/id/708193/pl

European Union, 2023