Periodic Reporting for period 3 - AIMMS STAR-PLUS (Scientific Top Training in Antimicrobial Research) Okres sprawozdawczy: 2020-09-01 do 2022-12-31 Podsumowanie kontekstu i ogólnych celów projektu The problem and its importance for societyThe introduction of antimicrobial drugs in the mid-to-late 20th century has saved the lives and eased the suffering of many millions of people globally. In recent years microbial resistance to these antimicrobial drugs has emerged and now means that once treatable infections are fast becoming refractory to multiple types of antimicrobial drugs. The development of antimicrobial resistance is no longer the theoretical threat it once was – in the EU alone, multidrug-resistant bacteria appear to be responsible for more than 25,000 deaths per year with associated healthcare costs running into many billions of Euros. This issue is now so serious that the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) now consider antimicrobial resistance to be a major health threat in Europe in the 21st century.The overall objectives• To use an innovative selection procedure for international Top Master's Students to train a new generation of top scientists who can contribute to solving the problem of bacterial, viral and parasitic diseases.• To train a new breed of excellent young scientists, familiar with the whole scope of drug discovery and development, ADME and safety, systems biology, microbiology and molecular biology who have the skills to become the researchers of the future.• To extend the AIMMS STAR programme internationally with four additional PhD positions resulting in an established international AIMMS STAR PLUS programme, with a dedicated, open selection procedure for top-talented MSc- / PhD-students from across Europe.ConclusionsIn our innovative selection rounds in which the 5 selected researchers wrote their own project. This allowed these young researchers to work really on their own ideas and gave them strong ownership. Their work on identifying and tacking some of the challenges in developing new antibiotics are expected to aid in the development of much needed new antibiotics. 3 researchers completed their projects and have become independent scientist ready for the next step in their (scientific) lives. Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty As the ESRs have a promotor and co-promotor that come from different departments within AIMMS they already experience working in a multidisciplinary environments. The ESRs have each contributed to research papers and are currently writing their thesis.Now at the end of the project, we have delivered independent scientists that contributed to 7 peer reviewed publications and organised scientific symposia and event for the general public. Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu) In our innovative selection rounds in which they wrote their own project. This was a very useful training and gave them strong ownership of their project. This also helped them to reflect on themselves and the project in a more profound way than would have occurred if they would have started on a project that was written by a primary investigator.Their work on identifying and tacking some of the challenges in developing new antibiotics are expected to aid in the development of much needed new antibiotics. Pints of Science is a event for the general public where one of ESRs presented her work
