Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients

Rezultaty

Dissemination of the project through outputs with the highest possible academic impact

Diseemination of research publications

Annual physical TOPCAPI consortium, SC, EAB, and IMB meetings

Annual physical TOPCAPI consortium SC EAB and IMB meetings

Full open release of generic project resources/tools

Full open release of generic project resourcestools

Project manager appointed

Communicate/outreach with the public

Publicly accessible TOPCAPI website newsletter publications press releases social media accounts outreach activities and each academic Partner will have Institutional open days

International conference to coincide with the last annual meeting
TOPCAPI Website

Publikacje

Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling

Autorzy: Areti Tsigkinopoulou, Eriko Takano, Rainer Breitling
Opublikowane w: PLOS Computational Biology, Numer 16/7, 2020, Strona(/y) e1008039, ISSN 1553-7358
Wydawca: PLOS
DOI: 10.1371/journal.pcbi.1008039

Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A

Autorzy: Francesco Del Carratore, Marianna Iorio, Mercedes Pérez-Bonilla, Kamila Schmidt, Rosario Pérez-Redondo, Margherita Sosio, Sandy J. Macdonald, Ivan S. Gyulev, Areti Tsigkinopoulou, Gavin H. Thomas, Olga Genilloud, Antonio Rodríguez-García, Stefano Donadio, Rainer Breitling, Eriko Takano
Opublikowane w: mSystems, Numer 6/3, 2021, ISSN 2379-5077
Wydawca: ASM Journals
DOI: 10.1128/msystems.00341-21

Structure and Function of an Elongation Factor P Subfamily in Actinobacteria

Autorzy: Bruno Pinheiro, Christopher M. Scheidler, Pavel Kielkowski, Marina Schmid, Ignasi Forné, Suhui Ye, Norbert Reiling, Eriko Takano, Axel Imhof, Stephan A. Sieber, Sabine Schneider, Kirsten Jung
Opublikowane w: Cell Reports, Numer 30/13, 2020, Strona(/y) 4332-4342.e5, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.03.009

Synthetic biology approaches to actinomycete strain improvement

Autorzy: Rainer Breitling, Martina Avbelj, Oksana Bilyk, Francesco Del Carratore, Alessandro Filisetti, Erik K R Hanko, Marianna Iorio, Rosario Pérez Redondo, Fernando Reyes, Michelle Rudden, Emmanuele Severi, Lucija Slemc, Kamila Schmidt, Dominic R Whittall, Stefano Donadio, Antonio Rodríguez García, Olga Genilloud, Gregor Kosec, Davide De Lucrezia, Hrvoje Petković, Gavin Thomas, Eriko Takano
Opublikowane w: FEMS Microbiology Letters, Numer 368/10, 2021, ISSN 1574-6968
Wydawca: Oxford University Press
DOI: 10.1093/femsle/fnab060

Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces

Autorzy: Suhui Ye, Behnam Enghiad, Huimin Zhao, Eriko Takano
Opublikowane w: Journal of Industrial Microbiology and Biotechnology, Numer 47/4-5, 2020, Strona(/y) 413-423, ISSN 1367-5435
Wydawca: Springer Verlag
DOI: 10.1007/s10295-020-02277-5

Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries

Autorzy: Andrew Currin, Neil Swainston, Mark S Dunstan, Adrian J Jervis, Paul Mulherin, Christopher J Robinson, Sandra Taylor, Pablo Carbonell, Katherine A Hollywood, Cunyu Yan, Eriko Takano, Nigel S Scrutton, Rainer Breitling
Opublikowane w: Synthetic Biology, Numer 4/1, 2019, ISSN 2397-7000
Wydawca: Oxford University Press
DOI: 10.1093/synbio/ysz025

Defining informative priors for ensemble modeling in systems biology

Autorzy: Areti Tsigkinopoulou, Aliah Hawari, Megan Uttley, Rainer Breitling
Opublikowane w: Nature Protocols, Numer 13/11, 2018, Strona(/y) 2643-2663, ISSN 1754-2189
Wydawca: Nature Publishing Group
DOI: 10.1038/s41596-018-0056-z

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Autorzy: Katsuaki Nitta, Francesco Del Carratore, Rainer Breitling, Eriko Takano, Sastia P. Putri, Eiichiro Fukusaki
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 8, 2020, Strona(/y) 595552, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2020.595552

Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism

Autorzy: Adam Amara, Eriko Takano, Rainer Breitling
Opublikowane w: BMC Genomics, Numer 19/1, 2018, ISSN 1471-2164
Wydawca: BioMed Central
DOI: 10.1186/s12864-018-4905-5

Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters

Autorzy: Francesco Del Carratore, Konrad Zych, Matthew Cummings, Eriko Takano, Marnix H. Medema, Rainer Breitling
Opublikowane w: Communications Biology, Numer 2/1, 2019, ISSN 2399-3642
Wydawca: Springer Nature
DOI: 10.1038/s42003-019-0333-6

Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships

Autorzy: Francesco Del Carratore, Kamila Schmidt, Maria Vinaixa, Katherine A. Hollywood, Caitlin Greenland-Bews, Eriko Takano, Simon Rogers, Rainer Breitling
Opublikowane w: Analytical Chemistry, Numer 91/20, 2019, Strona(/y) 12799-12807, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.9b02354

Antibiotic export: transporters involved in the final step of natural product production

Autorzy: Emmanuele Severi, Gavin H. Thomas
Opublikowane w: Microbiology, Numer 165/8, 2019, Strona(/y) 805-818, ISSN 1350-0872
Wydawca: Society for General Microbiology
DOI: 10.1099/mic.0.000794

The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

Autorzy: Kai Blin, Victòria Pascal Andreu, Emmanuel L C de los Santos, Francesco Del Carratore, Sang Yup Lee, Marnix H Medema, Tilmann Weber
Opublikowane w: Nucleic Acids Research, Numer 47/D1, 2018, Strona(/y) D625-D630, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gky1060

A plasmid toolset for CRISPR‐mediated genome editing and CRISPRi gene regulation in Escherichia coli.

Autorzy: Adrian J. Jervis, Erik K.R. Hanko, Mark S. Dunstan, Christopher J. Robinson, Eriko Takano, Nigel S. Scrutton
Opublikowane w: Microbial Biotechnology, Numer 14/3, 2021, Strona(/y) 1120-1129, ISSN 1751-7915
Wydawca: John Wiley and Sons Ltd
DOI: 10.1111/1751-7915.13780

Metabolomics tools for the synthetic biology of natural products

Autorzy: Katherine A Hollywood, Kamila Schmidt, Eriko Takano, Rainer Breitling
Opublikowane w: Current Opinion in Biotechnology, Numer 54, 2018, Strona(/y) 114-120, ISSN 0958-1669
Wydawca: Elsevier BV
DOI: 10.1016/j.copbio.2018.02.015

Switchable foldamer ion channels with antibacterial activity

Autorzy: Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft, Simon J. Webb
Opublikowane w: Chemical Science, Numer 11/27, 2020, Strona(/y) 7023-7030, ISSN 2041-6520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0sc02393k

Molecular Biology Methods in Streptomyces rimosus, a Producer of Oxytetracycline

Autorzy: Lucija Slemc, Špela Pikl, Hrvoje Petković, Martina Avbelj
Opublikowane w: Antimicrobial Therapies - Methods and Protocols, Numer 2296, 2021, Strona(/y) 303-330, ISBN 978-1-0716-1357-3
Wydawca: Springer US
DOI: 10.1007/978-1-0716-1358-0_18

Coupled Transcriptomics for Differential Expression Analysis and Determination of Transcription Start Sites: Design and Bioinformatics

Autorzy: Antonio Rodríguez-García, Alberto Sola-Landa, Rosario Pérez-Redondo
Opublikowane w: Antimicrobial Therapies - Methods and Protocols, Numer 2296, 2021, Strona(/y) 263-278, ISBN 978-1-0716-1357-3
Wydawca: Springer US
DOI: 10.1007/978-1-0716-1358-0_16

Rezultaty

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