We have performed a large amount of work on combinatorial production techniques to make large libraries of unique DNA origami nanostructures in one pot. We have also performed extensive work on making polygonal DNA origami nanostructures that interact with cells in a programmed manner and patterning of molecules on DNA origami. One significant result has been the development of a technology for patterning of antigens on the nanoscale, and then use these to look at how antibodies bind to patterns of antigens in a manner more detailed than was previously possible. We were able, for the first time to publish details of how antibodies bind to antigens separated by nanoscale distances, something we believe will have impact on vaccine design (Shaw, Högberg et al., Nat. Nanotech. 2019) And very recently we discovered, that antibodies can transport themselves, like bipedal walkers, on surfaces of nanopatterned antigens (Hoffecker, Högberg et al., Nat. Comp. Sci. 2022). Yet another significant achievement have been another project that sprang out of the original ideas in the project but ended up in a different niche, namely the use of precise, nanoscale, peptide spacing to induce apoptosis on demand (Wang, Högberg et al. ACS Nano 2021) – a project we hope will allow us to develop prototype cancer-targeting devices in the future. The project has so far led to 5 scientific publications and 1 patent application and there are a number of papers and patent applications resulting from the project that remain to be submitted.
