Cel Sex differences are basic for reproduction, parenting and other social interactions. Pheromone secretions that are differentially perceived by males and females, release stereotypical behaviours in many species. I will study how simple connectivity switches in a Drosophila sexually-dimorphic neuronal circuit are assembled into complex networks, from sensory processing to behavioural control. 11-cis-Vaccenyl-acetate (cVA) is a male-pheromone eliciting sex-specific responses: attracts females and repels males. Sex-specific wiring of olfactory neurons reroutes cVA information, forming a developmental switch in information flow. Central aSP-g neurons receive cVA innervation in females but not males, while this cluster is implicated in male-male aggressive behaviour. The role of aSP-g in social interactions was not compared between sexes, and that is my first aim. Next, I will find input and output neurons of aSP-g neurons in both sexes, by combining state-of-the-art anatomical, physiological and behavioural methodology: in-silico circuit-tracing methods to find neurons with overlapping innervations to aSP-g; and a unique electron-microscopy volume scan of a female brain to reconstruct aSP-g neurons and their synaptic partners. I will validate functional connectivity using photoactivation of output neurons while calcium-imaging target neurons. I aim to discover how sexually-specific wiring differences in homologous circuits regulate sexually-dimorphic social behaviours. These basic neuronal connectivity motifs may be conserved beyond flies. Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2016 - Individual Fellowships Zaproszenie do składania wniosków H2020-MSCA-IF-2016 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator UNITED KINGDOM RESEARCH AND INNOVATION Wkład UE netto € 195 454,80 Adres POLARIS HOUSE NORTH STAR AVENUE SN2 1FL Swindon Zjednoczone Królestwo Zobacz na mapie Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 195 454,80
