Periodic Reporting for period 1 - FOOTLOOSE (Synthesis of sp3-Rich Organofluorine Compounds through Homologation of Boronic Esters)
Okres sprawozdawczy: 2017-07-27 do 2019-07-26
Although a range of methodologies have been applied to the stereoselective synthesis of organofluorine compounds, a notable omition is the stereospecific Lithiation-Borylation of boronic esters, a reaction which has enjoyed considerable success in making complex molecule. The main challenge in extending this method to fluorinated substrates is associated with the stability of the corresponding starting materials (fluorinatedorganolithiums) which is decomposing while it is being formed in the reaction. Unfortunately, it is difficult to render stereoselective method without addressing starting material stability issue. Our strategy is to find the system as well as suitable conditions to have increased stability of starting material.