The number of worldwide car sold has steadily increased for decades. According to the Beijing Traffic Management Bureau, Beijing had 6.3 million motor vehicles by March 2020, which was an increase of 4.8 million since 2000. Such a huge number of vehicles running on the roads have significantly improved human’s life quality, but also brought a series of traffic accident and jam problems, which cause millions of life casualties, unquantifiable wasted time/capitals/energy, and serious global pollution issues. For instance, the Global Status Reports on Road Safety launched by the World Health Organization (WHO) reported that road traffic crashes had caused over 1.25 million deaths annually and become the leading killer of young people. Although many governments and automobile manufacturers are continuously working on constructing new roads and bridges, optimizing traffic rules, and developing better automobile life-protection and navigation technologies, it is widely accepted that conventional traffic management and automobile engineering approaches cannot completely solve these issues. Integrating advanced sensing, communication, and computing technologies to enable ITS is widely believed to be the solution. As a key element in ITS, smart autonomous driving cars will play a key role for reducing traffic accident, jam rates, environment pollution, and the burden of drivers. However, although a number of recent high-profile successful experimental results may give the impression that the day fully-functional autonomous cars running on the roads would come soon, in fact numerous scientific and technical challenges still await to be solved, since actions and decisions in transportation systems after all are related to human life and hence must be taken with caution. In this project, we have developed several novel methods to support efficient and reliable sensing data transmission and processing over VCNs. The results achieved in the project can serve as theoretic tools and potential technical solutions for supporting the development of future autonomous driving functions to address traffic problems, and hence bring benefits for the society.