Driving next generation autophagy researchers towards translation

Rezultaty

Press release on projects results

Press Release after Kick-off meeting

Visual and listening communication through an animation movie to explain complex scientific principles will allow a large audience to understand the core aspects of DRIVE

DRIVE website

Project's website with public information about DRIVE's objectives, events and discoveries.

Autophagy Reviews

Group reviews for the journal Autophagy

Updated Network Training Program

Ensure that all ESRs receive the same training opportunities on the issues that are recognized as essential by the DRIVE consortium. This can be achieved through harmonising the local training opportunities or through training offered by the network.

Drive's Good Practices Report

Summary report about DRIVEs good practices regarding Principles of Innovative Doctoral Training and genderbalance

Publikacje

Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease.

Autorzy: Inés Maestro; Inés Maestro; Laura R. de la Ballina; Anne Simonsen; Patricia Boya; Ana Martínez; Ana Martínez
Opublikowane w: ACS Chemical Neuroscience, Numer 12(24), 2021, Strona(/y) 4512- 4523, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.1c00529

The multi-functional SNARE protein Ykt6 in autophagosomal fusion processes

Autorzy: Franziska Kriegenburg, Levent Bas, Jieqiong Gao, Christian Ungermann, Claudine Kraft
Opublikowane w: Cell Cycle, Numer 18/6-7, 2019, Strona(/y) 639-651, ISSN 1538-4101
Wydawca: Landes Bioscience
DOI: 10.1080/15384101.2019.1580488

Mitophagy Modulation, a New Player in the Race against ALS

Autorzy: Enrique Madruga, Inés Maestro, Ana Martínez
Opublikowane w: International Journal of Molecular Sciences, Numer 22/2, 2021, Strona(/y) 740, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020740

The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models

Autorzy: Ines Rosignol, Beatriz Villarejo-Zori, Petra Teresak, Elena Sierra-Filardi, Xandra Pereiro, Natalia Rodríguez-Muela, Elena Vecino, Helena L. A. Vieira, Katharina Bell, Patricia Boya
Opublikowane w: International Journal of Molecular Sciences, Numer 21/5, 2020, Strona(/y) 1882, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051882

Phosphoregulation of the autophagy machinery by kinases and phosphatases

Autorzy: Mariya Licheva; Babu Raman; Claudine Kraft; Fulvio Reggiori
Opublikowane w: Autophagy, Numer 25, 2021, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2021.1909407

An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates

Autorzy: Daniel Poveda-Huertes, Stanka Matic, Adinarayana Marada, Lukas Habernig, Mariya Licheva, Lisa Myketin, Ralf Gilsbach, Sergi Tosal-Castano, Daniel Papinski, Patrycja Mulica, Oliver Kretz, Cansu Kücükköse, Asli Aras Taskin, Lutz Hein, Claudine Kraft, Sabrina Büttner, Chris Meisinger, F.-Nora Vögtle
Opublikowane w: Molecular Cell, Numer 77/1, 2020, Strona(/y) 180-188.e9, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2019.09.026

Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods

Autorzy: Tiziana Ginex, Urtzi Garaigorta, David Ramírez, Victoria Castro, Vanesa Nozal, Inés Maestro, Javier García-Cárceles, Nuria E. Campillo, Ana Martinez, Pablo Gastaminza, Carmen Gil
Opublikowane w: Pharmaceuticals, Numer 14/4, 2021, Strona(/y) 332, ISSN 1424-8247
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14040332

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

Autorzy: Gabriela Andrejeva, Sharon Gowan, Gigin Lin, Anne-Christine LF Wong Te Fong, Elham Shamsaei, Harry G. Parkes, James Mui, Florence I. Raynaud, Yasmin Asad, Gema Vizcay-Barrena, Joanna Nikitorowicz-Buniak, Melanie Valenti, Louise Howell, Roland A. Fleck, Lesley-Ann Martin, Vladimir Kirkin, Martin O. Leach, Yuen-Li Chung
Opublikowane w: Autophagy, Numer 16/6, 2020, Strona(/y) 1044-1060, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2019.1659608

Targeting autophagy in disease: established and new strategies

Autorzy: Muhammed Kocak, Saba Ezazi Erdi, Guillem Jorba, Inés Maestro, Judith Farrés, Vladimir Kirkin, Ana Martinez, Ole Pless
Opublikowane w: Autophagy, 2021, Strona(/y) 1-23, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2021.1936359

Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae

Autorzy: David M. Hollenstein, Rubén Gómez-Sánchez, Akif Ciftci, Franziska Kriegenburg, Muriel Mari, Raffaela Torggler, Mariya Licheva, Fulvio Reggiori, Claudine Kraft
Opublikowane w: Journal of Cell Science, Numer 132/22, 2019, Strona(/y) jcs235002, ISSN 0021-9533
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/jcs.235002

Selective Autophagy Receptors in Neuronal Health and Disease

Autorzy: Owen Conway, Hafize Aysin Akpinar, Vladimir V. Rogov, Vladimir Kirkin
Opublikowane w: Journal of Molecular Biology, Numer 432/8, 2020, Strona(/y) 2483-2509, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2019.10.013

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle

Autorzy: Ruth Steinberg, Andrea Origi, Ana Natriashvili, Pinku Sarmah, Mariya Licheva, Princess M. Walker, Claudine Kraft, Stephen High, Joen Luirink, Wei. Q. Shi, Martin Helmstädter, Maximilian H. Ulbrich, Hans-Georg Koch
Opublikowane w: PLOS Biology, Numer 18/9, 2020, Strona(/y) e3000874, ISSN 1545-7885
Wydawca: Plos Biology
DOI: 10.1371/journal.pbio.3000874

Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion

Autorzy: Levent Bas, Daniel Papinski, Mariya Licheva, Raffaela Torggler, Sabrina Rohringer, Martina Schuschnig, Claudine Kraft
Opublikowane w: Journal of Cell Biology, Numer 217/10, 2018, Strona(/y) 3656-3669, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.201804028

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

Autorzy: Jieqiong Gao, Lars Langemeyer, Daniel Kümmel, Fulvio Reggiori, Christian Ungermann
Opublikowane w: eLife, Numer 7, 2018, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/eLife.31145

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

Autorzy: Claudine Kraft, Patricia Boya, Patrice Codogno, Zvulun Elazar, Eeva-Liisa Eskelinen, Judith Farrés, Vladimir Kirkin, Heinz Jungbluth, Ana Martinez, Ole Pless, Charlotte Primard, Tassula Proikas-Cezanne, Anne Simonsen, Fulvio Reggiori
Opublikowane w: Autophagy, Numer 15/2, 2018, Strona(/y) 347-351, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2018.1515532

Atg1 kinase regulates autophagosome‐vacuole fusion by controlling SNARE bundling

Autorzy: Saskia Barz, Franziska Kriegenburg, Anna Henning, Anuradha Bhattacharya, Hector Mancilla, Pablo Sánchez‐Martín, Claudine Kraft
Opublikowane w: EMBO reports, 2020, ISSN 1469-221X
Wydawca: Nature Publishing Group
DOI: 10.15252/embr.202051869

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

Autorzy: Isabel Lastres-Becker, Gracia Porras, Marina Arribas-Blázquez, Inés Maestro, Daniel Borrego-Hernández, Patricia Boya, Sebastián Cerdán, Alberto García-Redondo, Ana Martínez, Ángeles Martin-Requero
Opublikowane w: International Journal of Molecular Sciences, Numer 22/6, 2021, Strona(/y) 3007, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063007

COVID-19: Drug Targets and Potential Treatments

Autorzy: Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E. Campillo, Ana Martinez
Opublikowane w: Journal of Medicinal Chemistry, Numer 63/21, 2020, Strona(/y) 12359-12386, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00606

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5

Autorzy: Jessica Huber, Miki Obata, Jens Gruber, Masato Akutsu, Frank Löhr, Natalia Rogova, Peter Güntert, Ivan Dikic, Vladimir Kirkin, Masaaki Komatsu, Volker Dötsch, Vladimir V. Rogov
Opublikowane w: Autophagy, Numer 16/2, 2020, Strona(/y) 256-270, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2019.1606637

Spatial control of avidity regulates initiation and progression of selective autophagy.

Autorzy: Hollenstein David M, Licheva Mariya, Konradi Nicole, Schweida David, Mancilla Hector, Mari Muriel, Reggiori Fulvio, Kraft Claudine
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-27420-3

Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

Autorzy: Nicole Wesch, Vladimir Kirkin, Vladimir V. Rogov
Opublikowane w: Cells, 2020, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells9092008

Autophagosomes are formed at a distinct cellular structure

Autorzy: David M. Hollenstein, Claudine Kraft
Opublikowane w: Current Opinion in Cell Biology, Numer 65, 2020, Strona(/y) 50-57, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2020.02.012

The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells

Autorzy: Caterina Miceli, Federica Roccio, Lucille Penalva-Mousset, Martine Burtin, Christine Leroy, Ivan Nemazanyy, Nicolas Kuperwasser, Marco Pontoglio, Gérard Friedlander, Etienne Morel, Fabiola Terzi, Patrice Codogno, Nicolas Dupont
Opublikowane w: Nature Cell Biology, Numer 22/9, 2020, Strona(/y) 1091-1102, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-020-0566-0

Ykt6 mediates autophagosome-vacuole fusion

Autorzy: Levent Bas, Daniel Papinski, Claudine Kraft
Opublikowane w: Molecular & Cellular Oncology, Numer 5/6, 2018, Strona(/y) e1526006, ISSN 2372-3556
Wydawca: Taylor and Francis
DOI: 10.1080/23723556.2018.1526006

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

Autorzy: Vladimir Kirkin, Vladimir V. Rogov
Opublikowane w: Molecular Cell, Numer 76/2, 2019, Strona(/y) 268-285, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2019.09.005

Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles

Autorzy: Vanesa Nozal, Elisa Rojas-Prats, Inés Maestro, Carmen Gil, Daniel I. Perez, Ana Martinez
Opublikowane w: International Journal of Molecular Sciences, Numer 22/6, 2021, Strona(/y) 3206, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063206

Small but mighty: Atg8s and Rabs in membrane dynamics during autophagy

Autorzy: Saskia, Barz; Franziska, Kriegenburg; Pablo, Sánchez-Martín; Claudine, Kraft
Opublikowane w: Biochimica et Biophysica Acta. Molecular Cell Research, Numer 26, 2021, ISSN 0167-4889
Wydawca: Elsevier BV
DOI: 10.1016/j.bbamcr.2021.119064

Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases

Autorzy: Ines Maestro, Patricia Boya, Ana Martinez
Opublikowane w: Expert Opinions on Therapeutical Targets, 2020, Strona(/y) 231-243
Wydawca: Taylor & Francis
DOI: 10.1080/14728222.2020.1730328

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