The role of cell-to-cell variability in pneumococcal virulence and antibiotic resistance

Informazioni relative al progetto

PneumoCaTChER

ID dell’accordo di sovvenzione: 771534

DOI 10.3030/771534

Progetto chiuso

Data della firma CE 13 Aprile 2018

Data di avvio 1 Novembre 2018

Data di completamento 31 Ottobre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 735,00

Contributo UE € 1 999 735,00

Coordinato da

UNIVERSITE DE LAUSANNE
Switzerland

Pubblicazioni

Peer reviewed articles (17)

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

Autori: Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening
Pubblicato in: eLife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.75607

Harnessing CRISPR-Cas9 for Genome Editing in Streptococcus pneumoniae D39V

Autori: Dimitra Synefiaridou, Jan-Willem Veening
Pubblicato in: Applied and Environmental Microbiology, Numero 87/6, 2021, ISSN 0099-2240
Editore: American Society for Microbiology
DOI: 10.1128/aem.02762-20

CcrZ is a pneumococcal spatiotemporal cell cycle regulator that interacts with FtsZ and controls DNA replication by modulating the activity of DnaA

Autori: Clement Gallay, Stefano Sanselicio, Mary E. Anderson, Young Min Soh, Xue Liu, Gro A. Stamsås, Simone Pelliciari, Renske van Raaphorst, Julien Dénéréaz, Morten Kjos, Heath Murray, Stephan Gruber, Alan D. Grossman, Jan-Willem Veening
Pubblicato in: Nature Microbiology, Numero 6/9, 2021, Pagina/e 1175-1187, ISSN 2058-5276
Editore: NPG
DOI: 10.1038/s41564-021-00949-1

Switching off: The phenotypic transition to the uninduced state of the lactose uptake pathway

Autori: Prasanna M Bhogale, Robin A Sorg, Jan-Willem Veening, Johannes Berg
Pubblicato in: Biophys J ., 2022, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2021.12.027

Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq

Autori: Xue Liu, Jacqueline M Kimmey, Laura Matarazzo, Vincent de Bakker, Laurye Van Maele, Jean-Claude Sirard, Victor Nizet, Jan-Willem Veening
Pubblicato in: Cell Host & Microbe, 2021, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2020.10.001

The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci

Autori: Paddy S Gibson, Evan Bexkens, Sylvia Zuber, Lauren A Cowley , Jan-Willem Veening
Pubblicato in: Plos Pathogens, 2022, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1010727

2FAST2Q: a general-purpose sequence search and counting program for FASTQ files

Autori: Afonso M Bravo, Athanasios Typas, Jan-Willem Veening
Pubblicato in: PeerJ, 2022, ISSN 2167-8359
Editore: PeerJ
DOI: 10.7717/peerj.14041

Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

Autori: Jun Kurushima, Nathalie Campo, Renske van Raaphorst, Guillaume Cerckel, Patrice Polard, Jan-Willem Veening
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.58771

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification

Autori: Natalie Bärland, Anne-Stéphanie Rueff, Gonzalo Cebrero, Cedric A J Hutter, Markus A Seeger, Jan-Willem Veening, Camilo Perez
Pubblicato in: Science Advances, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm1122

RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae

Autori: Chryslène Mercy, Adrien Ducret, Jelle Slager, Jean-Pierre Lavergne, Céline Freton, Sathya Narayanan Nagarajan, Pierre Simon Garcia, Marie-Francoise Noirot-Gros, Nelly Dubarry, Julien Nourikyan, Jan-Willem Veening, Christophe Grangeasse
Pubblicato in: Nature Microbiology, 2019, ISSN 2058-5276
Editore: Nature
DOI: 10.1038/s41564-019-0472-z

Three New Integration Vectors and Fluorescent Proteins for Use in the Opportunistic Human Pathogen Streptococcus pneumoniae

Autori: Lance E. Keller, Anne-Stéphanie Rueff, Jun Kurushima, Jan-Willem Veening
Pubblicato in: Genes, Numero 10/5, 2019, Pagina/e 394, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10050394

Refining the Pneumococcal Competence Regulon by RNA Sequencing

Autori: Jelle Slager, Rieza Aprianto, Jan-Willem Veening
Pubblicato in: Journal of Bacteriology, Numero 201/13, 2019, ISSN 0021-9193
Editore: American Society for Microbiology
DOI: 10.1128/jb.00780-18

BactMAP: An R package for integrating, analyzing and visualizing bacterial microscopy data

Autori: Renske Raaphorst, Morten Kjos, Jan‐Willem Veening
Pubblicato in: Molecular Microbiology, Numero 113/1, 2019, Pagina/e 297-308, ISSN 0950-382X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/mmi.14417

Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

Autori: Bing Zhang, Xue Liu, Elisabeth Lambert, Guillaume Mas, Sebastian Hiller, Jan-Willem Veening, Camilo Perez
Pubblicato in: Nature Structural & Molecular Biology, 2020, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-020-0425-5

Gaps in the wall: understanding cell wall biology to tackle amoxicillin resistance in Streptococcus pneumoniae

Autori: Paddy S Gibson, Jan-Willem Veening
Pubblicato in: Curr Opin Microbiol., 2023, ISSN 1369-5274
Editore: Elsevier BV
DOI: 10.1016/j.mib.2022.102261

Synthetic genetic oscillators demonstrate the functional importance of phenotypic variation in pneumococcal-host interactions

Autori: Anne-Stéphanie Rueff, Renske van Raaphorst, Surya D Aggarwal, Javier Santos-Moreno, Géraldine Laloux, Yolanda Schaerli, Jeffrey N Weiser, Jan-Willem Veening
Pubblicato in: Nature Communications, Numero 14(1):7454, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-43241-y

Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence

Autori: Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou, Daniel Straume, Max Brendel, Gonzalo Cebrero, Xue Liu, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Camilo Perez, Nicolas Gisch, Sven Hammerschmidt, Leiv Sigve Håvarstein, Jan-Willem Veening
Pubblicato in: Plos Biology, 2023, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001990