Breaking the limits in glycan recognition by NMR

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Publikacje

Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans

Autorzy: Angeles Canales, Javier Sastre, Jose M. Orduña, Cindy M. Spruit, Javier Pérez-Castells, Gema Domínguez, Kim M. Bouwman, Roosmarijn van der Woude, Francisco Javier Cañada, Corwin M. Nycholat, James C. Paulson, Geert-Jan Boons, Jesús Jiménez-Barbero, Robert P. de Vries
Opublikowane w: JACS Au, Numer 3, 2023, Strona(/y) 868-878, ISSN 2691-3704
Wydawca: American Chemical Society
DOI: 10.1021/jacsau.2c00664

The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin

Autorzy: Ana Diniz; Helena Coelho; Helena Coelho; Jorge S. Dias; Sandra J. van Vliet; Jesús Jiménez-Barbero; Jesús Jiménez-Barbero; Francisco Corzana; Eurico J. Cabrita; Filipa Marcelo
Opublikowane w: Chemistry A European Journal, Numer 5, 2019, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201902780

Synthetic Zwitterionic Streptococcus pneumoniae Type 1 Oligosaccharides Carrying Labile O ‐Acetyl Esters

Autorzy: Zhen Wang; Ana Gimeno; Marta G. Lete; Herman S. Overkleeft; Gijsbert A. van der Marel; Fabrizio Chiodo; Jesús Jiménez‐Barbero; Jeroen D. C. Codée
Opublikowane w: Angewandte Chemie (International Edition), 2022, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202211940

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Autorzy: Endika Prieto-Fernández, Leire Egia-Mendikute, Laura Vila-Vecilla, Alexandre Bosch, Adrián Barreira-Manrique, So Young Lee, Ana García-Del Río, Asier Antoñana-Vildosola, Borja Jiménez-Lasheras, Leire Moreno-Cugnon, Jesús Jiménez-Barbero, Edurne Berra, June Ereño-Orbea, Asis Palazon.
Opublikowane w: Emerging Microbes & Infections, 2021, ISSN 2222-1751
Wydawca: Nature Publishing Group
DOI: 10.1080/22221751.2021.1932607

Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction

Autorzy: Qingju Zhang, Ana Gimeno, Darielys Santana, Zhen Wang, Yury Valdés-Balbin, Laura M. Rodríguez-Noda, Thomas Hansen, Li Kong, Mengjie Shen, Herman S. Overkleeft, Vicente Vérez-Bencomo, Gijsbert A. van der Marel, Jesús Jiménez-Barbero, Fabrizio Chiodo, Jeroen D. C. Codée
Opublikowane w: ACS Central Science, Numer 5/8, 2019, Strona(/y) 1407-1416, ISSN 2374-7943
Wydawca: American Chemistry Society
DOI: 10.1021/acscentsci.9b00454

Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling

Autorzy: Coelho, Helena; de las Rivas, Matilde; Grosso, Ana S.; Diniz, Ana; Soares, Catia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Companon, Ismael; Sun, Lingbo; Narimatsu, Yoshiki; Vakhrushev, Sergey Y.; Clausen, Henrik; Cabrita, Eurico J.; Jimenez-Barbero, Jesus; Corzana, Francisco; Hurtado-Guerrero, Ramon; Marcelo, Filipa; 0000-0003-1992-8557; 0000-0001-5324-4998; 0000-0002-9102-3018; 0000-0001-9725-1
Opublikowane w: Journal of American Chemical Society, Numer 12, 2022, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacsau.1c00529

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Autorzy: Soledad Stagnoli; Francesca Peccati; Sean R. Connell; Ane Martinez-Castillo; Diego Charro; Oscar Millet; Chiara Bruzzone; Asis Palazon; Ana Ardá; Jesús Jiménez-Barbero; June Ereño-Orbea; Nicola G. A. Abrescia; Gonzalo Jiménez-Osés
Opublikowane w: Frontiers in Microbiology, Numer 7, 2022, ISSN 1664-302X
Wydawca: Frontiers Media
DOI: 10.3389/fmicb.2022.870938

The impact of glycosylation on the structure, function, and interactions of CD14

Autorzy: Jon Imanol Quintana, Sandra Delgado, Miriam Rábano, Mikel Azkargorta, Mirane Florencio-Zabaleta, Luca Unione, Maria dM Vivanco, Félix Elortza, Jesús Jiménez-Barbero, Ana Ardá
Opublikowane w: Glycobiology, Numer 34, 2024, ISSN 1460-2423
Wydawca: Oxford University Press
DOI: 10.1093/glycob/cwae002

An Epoxide Intermediate in Glycosidase Catalysis

Autorzy: Lukasz F. Sobala, Gaetano Speciale, Sha Zhu, Lluıs Raich, Natalia Sannikova, Andrew J. Thompson, Zalihe Hakki, Dan Lu, Saeideh Shamsi Kazem Abadi, Andrew R. Lewis, Vıctor Rojas-Cervellera, ́ Ganeko Bernardo-Seisdedos, Yongmin Zhang, Oscar Millet, Jesus Jiménez-Barbero, Andrew J. Bennet, ́ Matthieu Sollogoub, Carme Rovira, Gideon J. Davies, and Spencer J. Williams
Opublikowane w: ACS Central Science, 2020, ISSN 2374-7951
Wydawca: American Chemical Society
DOI: 10.1021/acscentsci.0c00111

The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View

Autorzy: Luca Unione; María J. Moure; Maria Pia Lenza; Iker Oyenarte; June Ereño‐Orbea; Ana Ardá; Jesús Jiménez‐Barbero
Opublikowane w: Angewandte Chemie International Edition, Numer 2, 2022, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202201432

Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations

Autorzy: Jon I. Quintana, Sandra Delgado, Reyes Núñez-Franco, F. Javier Cañada, Gonzalo Jiménez-Osés, Jesús Jiménez-Barbero, Ana Ardá
Opublikowane w: Frontiers in Chemistry, Numer 9, 2021, ISSN 2296-2646
Wydawca: Frontiers Media SA
DOI: 10.3389/fchem.2021.664097

Exploring galectin interactions with human milk oligosaccharides and blood group antigens identifies BGA6 as a functional galectin-4 ligand

Autorzy: Alejandro J. Cagnoni, Mora Massaro, Anabela M. Cutine, Ana Gimeno, Juan M. Pérez-Sáez, Montana N. Manselle Cocco, Sebastián M. Maller, Santiago Di Lella, Jesús Jiménez-Barbero, Ana Ardá, Gabriel A. Rabinovich, Karina V. Mariño
Opublikowane w: Journal of Biological Chemistry, Numer 300, 2024, Strona(/y) 107573, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.107573

Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by 19 F NMR Spectroscopy

Autorzy: J. Daniel Martínez, Ana I. Manzano, Eva Calviño, Ana de Diego, Borja Rodriguez de Francisco, Cecilia Romanò, Stefan Oscarson, Oscar Millet, Hans-Joachim Gabius, Jesús Jiménez-Barbero, Francisco J. Cañada
Opublikowane w: The Journal of Organic Chemistry, Numer 85/24, 2020, Strona(/y) 16072-16081, ISSN 0022-3263
Wydawca: American Chemical Society
DOI: 10.1021/acs.joc.0c01830

Novel NMR Avenues to Explore the Conformation and Interactions of Glycans

Autorzy: Pablo Valverde, Jon I. Quintana, Jose I. Santos, Ana Ardá, Jesús Jiménez-Barbero
Opublikowane w: ACS Omega, Numer 4/9, 2019, Strona(/y) 13618-13630, ISSN 2470-1343
Wydawca: American Chemical Society
DOI: 10.1021/acsomega.9b01901

Targeting Galectins With Glycomimetics

Autorzy: Sara Bertuzzi, Jon I. Quintana, Ana Ardá, Ana Gimeno, Jesús Jiménez-Barbero
Opublikowane w: Frontiers in Chemistry, Numer 8, 2020, ISSN 2296-2646
Wydawca: Frontiers Media
DOI: 10.3389/fchem.2020.00593

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

Autorzy: Sara Bertuzzi, Ana Gimeno, Ane Martinez-Castillo, Marta G. Lete, Sandra Delgado, Cristina Airoldi, Marina Rodrigues Tavares, Markéta Bláhová, Petr Chytil, Vladimír Křen, Nicola G. A. Abrescia, Ana Ardá, Pavla Bojarová, Jesús Jiménez-Barbero
Opublikowane w: International Journal of Molecular Sciences, Numer 22/11, 2021, Strona(/y) 6000, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22116000

Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin‐1

Autorzy: Sara Bertuzzi, Ana Gimeno, Reyes Núñez‐Franco, Ganeko Bernardo‐Seisdedos, Sandra Delgado, Gonzalo Jiménez‐Osés, Oscar Millet, Jesús Jiménez‐Barbero, Ana Ardá
Opublikowane w: Chemistry – A European Journal, Numer 26/67, 2020, Strona(/y) 15643-15653, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003212

The two domains of human galectin-8 bind sialyl- and fucose-containing oligosaccharides in an independent manner. A 3D view by using NMR

Autorzy: Marcos Gómez-Redondo, Sandra Delgado, Reyes Núñez-Franco, Gonzalo Jiménez-Osés, Ana Ardá, Jesús Jiménez-Barbero, Ana Gimeno
Opublikowane w: RSC Chemical Biology, Numer 2/3, 2021, Strona(/y) 932-941, ISSN 2633-0679
Wydawca: RSC
DOI: 10.1039/d1cb00051a

Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.

Autorzy: Ellen Y. Cotrina; Ana Gimeno; Jordi Llop; Jesús Jiménez-Barbero; Jesús Jiménez-Barbero; Jordi Quintana; Gregorio Valencia; Isabel Cardoso; Isabel Cardoso; Rafel Prohens; Gemma Arsequell
Opublikowane w: Journal of Medicinal Chemistry, Numer 3, 2020, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.9b01970

Synthesis and Structural Analysis of Aspergillus fumigatus Galactosaminogalactans Featuring α-Galactose, α-Galactosamine and α-N-Acetyl Galactosamine Linkages

Autorzy: Yongzhen Zhang; Marcos Gómez-Redondo; Gonzalo Jiménez-Osés; Ana Ardá; Herman S. Overkleeft; Gijsbert A. van der Marel; Jesús Jiménez-Barbero; Jeroen D. C. Codée
Opublikowane w: Angewandte Chemie International Edition, Numer 7, 2020, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202003951

Quantifying Siglec-sialylated ligand interactions: a versatile 19F-T2 CPMG filtered competitive NMR displacement assay

Autorzy: Unai Atxabal, Andrea Fernández, Maria Jesús Moure, Klaudia Sobczak, Corwin Nycholat, Verónica Almeida-Marrero, Iker Oyenarte, James C. Paulson, Andrés de la Escosura, Tomás Torres, Niels C. Reichardt, Jesús Jiménez-Barbero, June Ereño-Orbea
Opublikowane w: Chemical Science, Numer 15, 2024, Strona(/y) 10612-10624, ISSN 2041-6520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4sc01723d

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Autorzy: Carlo Pifferi, Leire Aguinagalde, Ane Ruiz-de-Angulo, Nagore Sacristán, Priscila Tonon Baschirotto, Ana Poveda, Jesús Jiménez-Barbero, Juan Anguita, Alberto Fernández-Tejada
Opublikowane w: Chemical Science, Numer 14, 2024, Strona(/y) 3501-3513, ISSN 2041-6520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2sc05639a

Molecular Recognition in C‐Type Lectins: The Cases of DC‐SIGN, Langerin, MGL, and L‐Sectin

Autorzy: Pablo Valverde, J. Daniel Martínez, F. Javier Cañada, Ana Ardá, Jesús Jiménez‐Barbero
Opublikowane w: ChemBioChem, Numer 21/21, 2020, Strona(/y) 2999-3025, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000238

Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions

Autorzy: Antonio Franconetti; Ana Ardá; Juan Luis Asensio; Yves Blériot; Sébastien Thibaudeau; Jesús Jiménez-Barbero; Jesús Jiménez-Barbero
Opublikowane w: Accounts of Chemical Research, Numer 2, 2021, ISSN 0001-4842
Wydawca: American Chemical Society
DOI: 10.1021/acs.accounts.1c00021

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Autorzy: Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon, June Ereño-Orbea
Opublikowane w: Nature Communications, Numer 14, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-39119-8

Oligosaccharide Presentation Modulates the Molecular Recognition of Glycolipids by Galectins on Membrane Surfaces

Autorzy: Marta G. Lete; Antonio Franconetti; Sandra Delgado; Jesús Jiménez-Barbero; Ana Ardá
Opublikowane w: Pharmaceuticals, 2022, ISSN 1424-8247
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15020145

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Autorzy: Bruno Linclau, Ana Ardá, Niels-Christian Reichardt, Matthieu Sollogoub, Luca Unione, Stéphane P. Vincent, Jesús Jiménez-Barbero
Opublikowane w: Chemical Society Reviews, Numer 49/12, 2020, Strona(/y) 3863-3888, ISSN 0306-0012
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9cs00099b

The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

Autorzy: J. Daniel Martínez, Angela S. Infantino, Pablo Valverde, Tammo Diercks, Sandra Delgado, Niels-Christian Reichardt, Ana Ardá, Francisco Javier Cañada, Stefan Oscarson, Jesús Jiménez-Barbero
Opublikowane w: Pharmaceuticals, Numer 13/8, 2020, Strona(/y) 179, ISSN 1424-8247
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080179

The Flexibility of Oligosaccharides Unveiled Through Residual Dipolar Coupling Analysis

Autorzy: Ana Poveda Giulio Fittolani Peter H. Seeberger Martina Delbianco and Jesús Jiménez-Barbero
Opublikowane w: Frontiers in Molecular Biosciences, 2021, ISSN 2296-889X
Wydawca: Frontiers Media
DOI: 10.3389/fmolb.2021.784318

Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin.

Autorzy: Bertuzzi, Sara; Peccati, Francesca; Serna, Sonia; Artschwager, Raik; Notova, Simona; Thépaut, Michel; Jiménez-Osés, Gonzalo; Fieschi, Franck; Reichardt, Niels C.; Jiménez-Barbero, Jesús; Ardá, Ana; 0000-0002-4242-7067; 0000-0003-0105-4337; 0000-0001-5421-8513; 0000-0003-3027-7417
Opublikowane w: ACS Central Science, Numer 2, 2022, ISSN 2374-7951
Wydawca: American Chemical Society
DOI: 10.1021/acscentsci.2c00719

Different roles of the heterodimer architecture of galectin-4 in selective recognition of oligosaccharides and lipopolysaccharides having ABH antigens

Autorzy: Jon I. Quintana, Mora Massaro, Alejandro J. Cagnoni, Reyes Nuñez-Franco, Sandra Delgado, Gonzalo Jiménez-Osés, Karina V. Mariño, Gabriel A. Rabinovich, Jesús Jiménez-Barbero, Ana Ardá
Opublikowane w: Journal of Biological Chemistry, Numer 300, 2024, Strona(/y) 107577, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.107577

NMR Investigation of Protein-Carbohydrate Interactions: The Recognition of Glycans by Galectins Engineered with Fluorotryptophan Residues

Autorzy: Lete, Marta G.; Franconetti, Antonio; Bertuzzi, Sara; Delgado, Sandra; Azkargorta, Mikel; Elortza, Félix; Millet, Oscar; Jiménez-Osés, Gonzalo; Arda, Ana; Jiménez-Barbero, Jesús; 0000-0002-9654-7881; 0000-0002-7972-8795; 0000-0002-4242-7067; 0000-0001-5848-6590; 0000-0001-8839-5438; 0000-0001-8748-4105; 0000-0003-0105-4337; 0000-0003-3027-7417; 0000-0001-5421-8513
Opublikowane w: Chemistry An European Journal, 2023, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202202208

Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling

Autorzy: Unai Atxabal, Corwin Nycholat, Johannes M. Pröpster, Andrea Fernández, Iker Oyenarte, Maria Pia Lenza, Antonio Franconetti, Cátia O. Soares, Helena Coelho, Filipa Marcelo, Mario Schubert, James C. Paulson, Jesús Jiménez-Barbero, June Ereño-Orbea
Opublikowane w: ACS Chemical Biology, Numer 19, 2024, Strona(/y) 483-496, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.3c00664

Molecular Insights into DC-SIGN Binding to Self-Antigens: The Interaction with the Blood Group A/B Antigens

Autorzy: Pablo Valverde, Sandra Delgado, J. Daniel Martínez, Jean-Baptiste Vendeville, Julien Malassis, Bruno Linclau, Niels-Christian Reichardt, Francisco Javier Cañada, Jesús Jiménez-Barbero, Ana Ardá
Opublikowane w: ACS Chemical Biology, Numer 14/7, 2019, Strona(/y) 1660-1671, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.9b00458

Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates

Autorzy: J. Daniel Martínez, Pablo Valverde, Sandra Delgado, Cecilia Romanò, Bruno Linclau, Niels C. Reichardt, Stefan Oscarson, Ana Ardá, Jesús Jiménez-Barbero, F. Javier Cañada
Opublikowane w: Molecules, Numer 24/12, 2019, Strona(/y) 2337, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24122337

Glycan structures and their interactions with proteins. A NMR view

Autorzy: Ana Gimeno, Pablo Valverde, Ana Ardá, Jesús Jiménez-Barbero
Opublikowane w: Current Opinion in Structural Biology, Numer 62, 2020, Strona(/y) 22-30, ISSN 0959-440X
Wydawca: Elsevier BV
DOI: 10.1016/j.sbi.2019.11.004

Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood‐Group Antigens by Human Galectin‐3

Autorzy: Ana Gimeno, Sandra Delgado, Pablo Valverde, Sara Bertuzzi, Manuel Alvaro Berbís, Javier Echavarren, Alessandra Lacetera, Sonsoles Martín‐Santamaría, Avadhesha Surolia, Francisco Javier Cañada, Jesus Jiménez‐Barbero, Ana Ardá
Opublikowane w: Angewandte Chemie International Edition, Numer 58/22, 2019, Strona(/y) 7268-7272, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900723

Avenues to Characterize the Interactions of Extended N‐Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case

Autorzy: Beatriz Fernández de Toro, Wenjie Peng, Andrew J. Thompson, Gema Domínguez, F. Javier Cañada, Javier Pérez‐Castells, James C. Paulson, Jesús Jiménez‐Barbero, Ángeles Canales
Opublikowane w: Angewandte Chemie International Edition, Numer 57/46, 2018, Strona(/y) 15051-15055, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201807162

Glycans in drug discovery

Autorzy: Pablo Valverde, Ana Ardá, Niels-Christian Reichardt, Jesús Jiménez-Barbero, Ana Gimeno
Opublikowane w: MedChemComm, Numer 10/10, 2019, Strona(/y) 1678-1691, ISSN 2040-2503
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9md00292h

Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog

Autorzy: Alexandra Bordes, Ana Poveda, Thibault Troadec, Antonio Franconetti, Ana Ardá, Flavie Perrin, Mickaël Ménand, Matthieu Sollogoub, Jerôme Guillard, Jérôme Désiré, Raphaël Tripier, Jesús Jiménez-Barbero, Yves Blériot
Opublikowane w: Organic Letters, Numer 22/6, 2020, Strona(/y) 2344-2349, ISSN 1523-7060
Wydawca: American Chemical Society
DOI: 10.1021/acs.orglett.0c00503

Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human Lectins

Autorzy: Maria Pia Lenza, Iker Oyenarte, Tammo Diercks, Jon Imanol Quintana, Ana Gimeno, Helena Coelho, Ana Diniz, Francesca Peccati, Sandra Delgado, Alexandre Bosch, Mikel Valle, Oscar Millet, Nicola G. A. Abrescia, Asís Palazón, Filipa Marcelo, Gonzalo Jiménez‐Osés, Jesús Jiménez‐Barbero, Ana Ardá, June Ereño‐Orbea
Opublikowane w: Angewandte Chemie International Edition, Numer 59/52, 2020, Strona(/y) 23763-23771, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011015

Current Status on Therapeutic Molecules Targeting Siglec Receptors

Autorzy: María Pia Lenza, Unai Atxabal, Iker Oyenarte, Jesús Jiménez-Barbero, June Ereño-Orbea
Opublikowane w: Cells, Numer 9/12, 2020, Strona(/y) 2691, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells9122691

Molecular Recognition of Glycan-Bearing Glycomacromolecules Presented at Membrane Surfaces by Lectins: An NMR View

Autorzy: Marta G. Lete, Miriam Hoffmann, Nils Schomann, Ane Martínez-Castillo, Francesca Peccati, Patrick B. Konietzny, Sandra Delgado, Nicole L. Snyder, Gonzalo Jiménez-Oses, Nicola G. A. Abrescia, Ana Ardá, Laura Hartmann, Jesús Jiménez-Barbero
Opublikowane w: ACS Omega, Numer 8, 2023, Strona(/y) 16883-16895, ISSN 2470-1343
Wydawca: American Chemical Society
DOI: 10.1021/acsomega.3c00634

Structures of the Inhibitory Receptor Siglec‑8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

Autorzy: Lenza, Maria Pia; Atxabal, Unai; Nycholat, Corwin; Oyenarte, Iker; Franconetti, Antonio; Quintana, Jon Imanol; Delgado, Sandra; Núñez-Franco, Reyes; Garnica Marroquín, Carmen Teresa; Coelho, Helena; Unione, Luca; Jiménez-Oses, Gonzalo; Marcelo, Filipa; Schubert, Mario; Paulson, James C.; Jiménez-Barbero, Jesús; Ereño-Orbea, June; 0000-0002-7972-8795; 0000-0003-1992-8557; 0000-0003-0105-4337
Opublikowane w: JACS Au, Numer 9, 2022, ISSN 2691-3704
Wydawca: American Chemical Society
DOI: 10.1021/jacsau.2c00592

Glycoprofile Analysis of an Intact Glycoprotein As Inferred by NMR Spectroscopy

Autorzy: Luca Unione, Maria Pia Lenza, Ana Ardá, Pedro Urquiza, Ana Laín, Juan Manuel Falcón-Pérez, Jesús Jiménez-Barbero, Oscar Millet
Opublikowane w: ACS Central Science, Numer 5/9, 2019, Strona(/y) 1554-1561, ISSN 2374-7943
Wydawca: American Chemical Society
DOI: 10.1021/acscentsci.9b00540

Selective 13 C‐Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins

Autorzy: María J. Moure, Ana Gimeno, Sandra Delgado, Tammo Diercks, Geert‐Jan Boons, Jesús Jiménez‐Barbero, Ana Ardá
Opublikowane w: Angewandte Chemie International Edition, Numer 60/34, 2021, Strona(/y) 18777-18782, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202106056

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