Periodic Reporting for period 1 - Hermes SR (Hermes Super Resolution microscopy system)
Okres sprawozdawczy: 2018-09-01 do 2019-08-31
This success prompted us to apply for the to FET Launchpad project to boost the commercialisation of Hermes SR. Hence, the name of this FET Launchpad proposal is Hermes SR."
We have identified the research community as the first Hermes SR customers. We recognise the need in the market for a dual-purpose automated microscope, capable of breaking the diffraction barrier to image at the nanoscale, while also having capabilities to image whole organisms. In this fashion, the new HermesSR will enable imaging biology at all scales on one single platform. This microscope will allow scientists for the first time to image multi well plates in nanometer resolution, uniting high content screening capabilities with the highest possible image resolution.
This revolutionary platform will have a meaningful and sustainable impact on researchers and their scientific accomplishments by establishing it as a ground-breaker in the realm of biological screening utilizing Super-Resolution techniques.
Our previous research data obtained from super-resolution imaging showed that cells that are fully differentiated into a specific cell type such as skin cells show a specific compacted conformation of the DNA and histones forming the chromatin fibers which is different in less differentiated like stem cells that show a decondensed chromatin structure. Using Hermes SR cutting edge capabilities we will be able to collect a number of chromatin and cytoplastic features associated to somatic and stem cells with nanoscale resolution in multiple cells at the same time. This will be of invaluable importance to fully characterize the phenotype of any cell types. For example, we will use the Hermes SR as a novel imaging diagnostic tool to study and characterize cancer cells from human samples