Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase 1 trial in Europe and sub-Saharan Africa

Informazioni relative al progetto

Vacc-iNTS

ID dell’accordo di sovvenzione: 815439

DOI

10.3030/815439

Data della firma CE 30 Aprile 2019

Data di avvio 1 Ottobre 2019

Data di completamento 31 Luglio 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

Nessun dato

Contributo UE

€ 6 871 188,73

Coordinato da

SCLAVO VACCINES ASSOCIATION
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan (DMP)

Websites, patent fillings, videos etc. (1)

Project website

Documents, reports (1)

Report on stakeholders meeting

Pubblicazioni

Peer reviewed articles (18)

Examining geospatial and temporal distribution of invasive non-typhoidal <i>Salmonella</i> disease occurrence in sub-Saharan Africa: a systematic review and modelling study

Autori: Jong-Hoon Kim, Bieke Tack, Fabio Fiorino, Elena Pettini, Christian S Marchello, Jan Jacobs, John A Crump, Florian Marks
Pubblicato in: BMJ Open, Numero 14, 2025, Pagina/e e080501, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-080501

Global distribution of <scp><i>Leptospira</i></scp> serovar isolations and detections from animal host species: <scp>A</scp> systematic review and online database

Autori: Nienke N. Hagedoorn, Michael J. Maze, Manuela Carugati, Shama Cash‐Goldwasser, Kathryn J. Allan, Kevin Chen, Brieuc Cossic, Elena Demeter, Sarah Gallagher, Richard German, Renee L. Galloway, Josipa Habuš, Matthew P. Rubach, Kanae Shiokawa, Nadezhda Sulikhan, John A. Crump
Pubblicato in: Tropical Medicine &amp; International Health, Numero 29, 2024, Pagina/e 161-172, ISSN 1360-2276
Editore: Blackwell Publishing Inc.
DOI: 10.1111/tmi.13965

Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

Autori: Christian S Marchello, PhD Megan Birkhold, MD Prof John A Crump, MD on behalf of theVacc-iNTS consortium collaborators
Pubblicato in: The Lancet Infectious Diseases, Numero 01406736, 2022, Pagina/e P692-705, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(21)00615-0

Nontyphoidal Salmonella Invasive Disease: Challenges and Solutions

Autori: John A Crump, Tonney S Nyirenda, Lisette Mbuyi Kalonji, Marie-France Phoba, Bieke Tack, James A Platts-Mills, Melita A Gordon, Samuel M Kariuki
Pubblicato in: Open Forum Infectious Diseases, Numero Volume 10, Numero Supplement_1, May 2023, 2023, Pagina/e S32–S37, ISSN 2328-8957
Editore: Oxford University Press on behalf of Infectious Diseases Society of America.
DOI: 10.1093/ofid/ofad020

Prevalence and distribution of non-typhoidal<i>Salmonella enterica</i>serogroups and serovars isolated from normally sterile sites: a global systematic review

Autori: Nienke N. Hagedoorn; Shruti Murthy; Megan Birkhold; Christian S. Marchello; John A. Crump
Pubblicato in: Crossref, Numero 3, 2024, ISSN 1469-4409
Editore: Cambridge Press
DOI: 10.1101/2023.06.13.23291315

Characterization of Enzyme-Linked Immunosorbent Assay (ELISA) for Quantification of Antibodies against Salmonella Typhimurium and Salmonella Enteritidis O-Antigens in Human Sera

Autori: Aruta MG, Lari E, De Simone D, Semplici B, Semplici C, Dale H, Chirwa E, Kadwala I, Mbewe M, Banda H, Iturriza-Gomara M, Gordon M, Nyirenda T, Piu P, Pizza M, Berlanda Scroza F, Grappi S, Canals R, Rossi O; Vacc-iNTS consortium collaborators.
Pubblicato in: BioTech., Numero 12(3), 2023, Pagina/e 54., ISSN 2673-6284
Editore: MDPI
DOI: 10.3390/biotech12030054

Direct association between rainfall and non-typhoidal Salmonella bloodstream infections in hospital-admitted children in the Democratic Republic of Congo

Autori: Bieke Tack, Daniel Vita, Marie-France Phoba, Lisette Mbuyi-Kalonji, Liselotte Hardy, Barbara Barbé, Jan Jacobs, Octavie Lunguya & Liesbet Jacobs
Pubblicato in: Scientific Reports, Numero 11, 2021, Pagina/e 21617, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-01030-x

Developing a clinical prediction model to modify empirical antibiotics for non-typhoidal Salmonella bloodstream infection in children under-five in the Democratic Republic of Congo

Autori: Bieke Tack, Daniel Vita, Jules Mbuyamba, Emmanuel Ntangu, Hornela Vuvu, Immaculée Kahindo, Japhet Ngina, Aimée Luyindula, Naomie Nama, Tito Mputu, Justin Im, Hyonjin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs, Ben Van Calster
Pubblicato in: BMC Infectious Diseases, Numero 25, 2025, ISSN 1471-2334
Editore: BioMed Central
DOI: 10.1186/s12879-024-10319-x

Development and Characterization of a Luminescence-Based High-Throughput Serum Bactericidal Assay (L-SBA) to Assess Bactericidal Activity of Human Sera against Nontyphoidal Salmonella

Autori: Aruta, Maria Grazia, Daniele De Simone, Helen Dale, Esmelda Chirwa, Innocent Kadwala, Maurice Mbewe, Happy Banda, Melita Gordon, Mariagrazia Pizza, Francesco Berlanda Scorza, and et al.
Pubblicato in: Methods and Protocols., 2023, Pagina/e 100, ISSN 2409-9279
Editore: MDPI
DOI: 10.3390/mps5060100

<i>Salmonella</i>Vaccine Study in Oxford (SALVO) trial: protocol for an observer-participant blind randomised placebo-controlled trial of the iNTS-GMMA vaccine within a European cohort

Autori: Brama Hanumunthadu; Nasir Kanji; Nelly Owino; Carla Ferreira Da Silva; Hannah Robinson; Rachel White; Pietro Ferruzzi; Usman Nakakana; Rocio Canals; Andrew J Pollard; Maheshi Ramasamy
Pubblicato in: Crossref, Numero 3, 2023, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-072938

Safety and immunogenicity of the invasive non-typhoidal Salmonella (iNTS)-GMMA vaccine: a first-in-human, randomised, dose escalation trial

Autori: Brama Hanumunthadu, Tesfaye Demissie, Melanie Greenland, Peter Skidmore, Kiarash Tanha, Tim Crocker-Buque, Nelly Owino, Antonella Silvia Sciré, Chiara Crispino, Daniele De Simone, Marta Benincasa, Maria Grazia Aruta, Omar Rossi, Anna Maria Colucci, Francesco Berlanda Scorza, Ashwani Kumar Arora, Xinxue Liu, Elizabeth A. Clutterbuck, Leila Godfrey, Rocio Canals, Maheshi N. Ramasamy, Francis Agyapo
Pubblicato in: eBioMedicine, Numero 119, 2026, Pagina/e 105903, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105903

Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo

Autori: Tack B, Vita D, Nketo J, Wasolua N, Ndengila N, Herssens N, et al
Pubblicato in: PLoS Negl Trop Dis, Numero 17(3), 2023, Pagina/e e0011156., ISSN 1935-2735
Editore: Plos Public Library of Science
DOI: 10.1371/journal.pntd.0011156

Incidence of non-typhoidal Salmonella invasive disease: A systematic review and meta-analysis

Autori: Marchello CS, Fiorino F, Pettini E, Crump JA; Vacc-iNTS Consortium Collaborators.
Pubblicato in: J Infect., Numero 15322742, 2021, ISSN 1532-2742
Editore: Elsevier Lsd
DOI: 10.1016/j.jinf.2021.06.029

Performance of Automated Point-of-Care Respiratory Rate Counting versus Manual Counting in Children under Five Admitted with Severe Febrile Illness to Kisantu Hospital, DR Congo

Autori: Tack, B.; Vita, D.; Mbaki, T.N.; Lunguya, O.; Toelen, J.; Jacobs, J.
Pubblicato in: Diagnostics, Numero 20754418, 2021, Pagina/e 2078, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics11112078

Challenges of Antibiotic Formulations and Administration in the Treatment of Bloodstream Infections in Children Under Five Admitted to Kisantu Hospital, Democratic Republic of Congo

Autori: Bieke Tack, Daniel Vita, Emmanuel Ntangu, Japhet Ngina, Pathy Mukoko, Adèle Lutumba, Dina Vangeluwe, Jaan Toelen, Karel Allegaert, Octavie Lunguya, Raffaella Ravinetto, Jan Jacobs
Pubblicato in: The American Journal of Tropical Medicine and Hygiene, Numero 109, 2023, Pagina/e 1245-1259, ISSN 0002-9637
Editore: American Society of Tropical Medicine and Hygiene
DOI: 10.4269/ajtmh.23-0322

Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS- vaccine studies in endemic countries: Seroepidemiology in Africa of iNTS (SAiNTS) Study Protocol: Malawi site [Version 9.0]

Autori: Helen Dale, Esmeda Chirwa, Priyanka Patel, Georgina Makuta, Felistas Mwakiseghile, Theresa Misiri, Innocent Kadwala, Maurice Mbewe, Happy Banda, Niza Silungwe, Kenneth Chizani, Paul Kambiya, Marc Henrion, Neil French, Tonny Nyirenda, Melita Gordon, null null
Pubblicato in: Wellcome Open Research, Numero 8, 2024, Pagina/e 27, ISSN 2398-502X
Editore: F1000 Research Ltd
DOI: 10.12688/wellcomeopenres.18054.2

Epidemiological cut-off value and antibiotic susceptibility test methods for azithromycin in a collection of multi-country invasive non-typhoidal Salmonella

Autori: Tack B, Phoba MF, Thong P, Lompo P, Hupko C, Desmet S, Martiny D, Mattheus W, Pardos de la Gandara M, Mbuyi-Kalonji L, Kuijpers L, Prevost B, Barbé B, Vandenberg O, Lunguya O, Ruiz J, Jacobs J, Hardy L.
Pubblicato in: Clin Microbiol Infect., Numero Dec;28(12), 2022, Pagina/e 1615-1623, ISSN 1469-0691
Editore: Elsevier
DOI: 10.1016/j.cmi.2022.06.009

Field Experiences with Handheld Diagnostic Devices to Triage Children under Five Presenting with Severe Febrile Illness in a District Hospital in DR Congo

Autori: Bieke Tack, Daniel Vita, Irène Mansosa, Thomas Nsema Mbaki, Naomie Wasolua, Aimée Luyindula, Jaan Toelen, Octavie Lunguya, Jan Jacobs
Pubblicato in: Diagnostics, Numero 12(3), 2022, Pagina/e 746, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics12030746

Other (2)

Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS- vaccine studies in endemic countries: Seroepidemiology in Africa of iNTS (SAiNTS) Study Protocol [Version 9.0]

Autori: Melita Gordon; Marc Henrion; Helen Dale
Pubblicato in: Crossref, Numero 2, 2023
Editore: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.18054.1

Effectiveness of iNTS vaccination in Sub-Saharan Africa

Autori: Cassese, Daniele; Dimitri, Nicola; Breghi, Gianluca; Spadafina, Tiziana
Pubblicato in: Numero 3, 2023
Editore: arXiv
DOI: 10.48550/arxiv.2303.18036