Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase 1 trial in Europe and sub-Saharan Africa

Informacje na temat projektu

Vacc-iNTS

Identyfikator umowy o grant: 815439

DOI

10.3030/815439

Data podpisania przez KE 30 Kwietnia 2019

Data rozpoczęcia 1 Października 2019

Data zakończenia 31 Lipca 2026

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

Brak danych

Wkład UE

€ 6 871 188,73

Koordynowany przez

SCLAVO VACCINES ASSOCIATION
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan (DMP)

Websites, patent fillings, videos etc. (1)

Project website

Documents, reports (1)

Report on stakeholders meeting

Publikacje

Peer reviewed articles (18)

Examining geospatial and temporal distribution of invasive non-typhoidal <i>Salmonella</i> disease occurrence in sub-Saharan Africa: a systematic review and modelling study

Autorzy: Jong-Hoon Kim, Bieke Tack, Fabio Fiorino, Elena Pettini, Christian S Marchello, Jan Jacobs, John A Crump, Florian Marks
Opublikowane w: BMJ Open, Numer 14, 2025, Strona(/y) e080501, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-080501

Global distribution of <scp><i>Leptospira</i></scp> serovar isolations and detections from animal host species: <scp>A</scp> systematic review and online database

Autorzy: Nienke N. Hagedoorn, Michael J. Maze, Manuela Carugati, Shama Cash‐Goldwasser, Kathryn J. Allan, Kevin Chen, Brieuc Cossic, Elena Demeter, Sarah Gallagher, Richard German, Renee L. Galloway, Josipa Habuš, Matthew P. Rubach, Kanae Shiokawa, Nadezhda Sulikhan, John A. Crump
Opublikowane w: Tropical Medicine &amp; International Health, Numer 29, 2024, Strona(/y) 161-172, ISSN 1360-2276
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/tmi.13965

Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

Autorzy: Christian S Marchello, PhD Megan Birkhold, MD Prof John A Crump, MD on behalf of theVacc-iNTS consortium collaborators
Opublikowane w: The Lancet Infectious Diseases, Numer 01406736, 2022, Strona(/y) P692-705, ISSN 0140-6736
Wydawca: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(21)00615-0

Nontyphoidal Salmonella Invasive Disease: Challenges and Solutions

Autorzy: John A Crump, Tonney S Nyirenda, Lisette Mbuyi Kalonji, Marie-France Phoba, Bieke Tack, James A Platts-Mills, Melita A Gordon, Samuel M Kariuki
Opublikowane w: Open Forum Infectious Diseases, Numer Volume 10, Numer Supplement_1, May 2023, 2023, Strona(/y) S32–S37, ISSN 2328-8957
Wydawca: Oxford University Press on behalf of Infectious Diseases Society of America.
DOI: 10.1093/ofid/ofad020

Prevalence and distribution of non-typhoidal<i>Salmonella enterica</i>serogroups and serovars isolated from normally sterile sites: a global systematic review

Autorzy: Nienke N. Hagedoorn; Shruti Murthy; Megan Birkhold; Christian S. Marchello; John A. Crump
Opublikowane w: Crossref, Numer 3, 2024, ISSN 1469-4409
Wydawca: Cambridge Press
DOI: 10.1101/2023.06.13.23291315

Characterization of Enzyme-Linked Immunosorbent Assay (ELISA) for Quantification of Antibodies against Salmonella Typhimurium and Salmonella Enteritidis O-Antigens in Human Sera

Autorzy: Aruta MG, Lari E, De Simone D, Semplici B, Semplici C, Dale H, Chirwa E, Kadwala I, Mbewe M, Banda H, Iturriza-Gomara M, Gordon M, Nyirenda T, Piu P, Pizza M, Berlanda Scroza F, Grappi S, Canals R, Rossi O; Vacc-iNTS consortium collaborators.
Opublikowane w: BioTech., Numer 12(3), 2023, Strona(/y) 54., ISSN 2673-6284
Wydawca: MDPI
DOI: 10.3390/biotech12030054

Direct association between rainfall and non-typhoidal Salmonella bloodstream infections in hospital-admitted children in the Democratic Republic of Congo

Autorzy: Bieke Tack, Daniel Vita, Marie-France Phoba, Lisette Mbuyi-Kalonji, Liselotte Hardy, Barbara Barbé, Jan Jacobs, Octavie Lunguya & Liesbet Jacobs
Opublikowane w: Scientific Reports, Numer 11, 2021, Strona(/y) 21617, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-01030-x

Developing a clinical prediction model to modify empirical antibiotics for non-typhoidal Salmonella bloodstream infection in children under-five in the Democratic Republic of Congo

Autorzy: Bieke Tack, Daniel Vita, Jules Mbuyamba, Emmanuel Ntangu, Hornela Vuvu, Immaculée Kahindo, Japhet Ngina, Aimée Luyindula, Naomie Nama, Tito Mputu, Justin Im, Hyonjin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs, Ben Van Calster
Opublikowane w: BMC Infectious Diseases, Numer 25, 2025, ISSN 1471-2334
Wydawca: BioMed Central
DOI: 10.1186/s12879-024-10319-x

Development and Characterization of a Luminescence-Based High-Throughput Serum Bactericidal Assay (L-SBA) to Assess Bactericidal Activity of Human Sera against Nontyphoidal Salmonella

Autorzy: Aruta, Maria Grazia, Daniele De Simone, Helen Dale, Esmelda Chirwa, Innocent Kadwala, Maurice Mbewe, Happy Banda, Melita Gordon, Mariagrazia Pizza, Francesco Berlanda Scorza, and et al.
Opublikowane w: Methods and Protocols., 2023, Strona(/y) 100, ISSN 2409-9279
Wydawca: MDPI
DOI: 10.3390/mps5060100

<i>Salmonella</i>Vaccine Study in Oxford (SALVO) trial: protocol for an observer-participant blind randomised placebo-controlled trial of the iNTS-GMMA vaccine within a European cohort

Autorzy: Brama Hanumunthadu; Nasir Kanji; Nelly Owino; Carla Ferreira Da Silva; Hannah Robinson; Rachel White; Pietro Ferruzzi; Usman Nakakana; Rocio Canals; Andrew J Pollard; Maheshi Ramasamy
Opublikowane w: Crossref, Numer 3, 2023, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-072938

Safety and immunogenicity of the invasive non-typhoidal Salmonella (iNTS)-GMMA vaccine: a first-in-human, randomised, dose escalation trial

Autorzy: Brama Hanumunthadu, Tesfaye Demissie, Melanie Greenland, Peter Skidmore, Kiarash Tanha, Tim Crocker-Buque, Nelly Owino, Antonella Silvia Sciré, Chiara Crispino, Daniele De Simone, Marta Benincasa, Maria Grazia Aruta, Omar Rossi, Anna Maria Colucci, Francesco Berlanda Scorza, Ashwani Kumar Arora, Xinxue Liu, Elizabeth A. Clutterbuck, Leila Godfrey, Rocio Canals, Maheshi N. Ramasamy, Francis Agyapo
Opublikowane w: eBioMedicine, Numer 119, 2026, Strona(/y) 105903, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105903

Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo

Autorzy: Tack B, Vita D, Nketo J, Wasolua N, Ndengila N, Herssens N, et al
Opublikowane w: PLoS Negl Trop Dis, Numer 17(3), 2023, Strona(/y) e0011156., ISSN 1935-2735
Wydawca: Plos Public Library of Science
DOI: 10.1371/journal.pntd.0011156

Incidence of non-typhoidal Salmonella invasive disease: A systematic review and meta-analysis

Autorzy: Marchello CS, Fiorino F, Pettini E, Crump JA; Vacc-iNTS Consortium Collaborators.
Opublikowane w: J Infect., Numer 15322742, 2021, ISSN 1532-2742
Wydawca: Elsevier Lsd
DOI: 10.1016/j.jinf.2021.06.029

Performance of Automated Point-of-Care Respiratory Rate Counting versus Manual Counting in Children under Five Admitted with Severe Febrile Illness to Kisantu Hospital, DR Congo

Autorzy: Tack, B.; Vita, D.; Mbaki, T.N.; Lunguya, O.; Toelen, J.; Jacobs, J.
Opublikowane w: Diagnostics, Numer 20754418, 2021, Strona(/y) 2078, ISSN 2075-4418
Wydawca: MDPI
DOI: 10.3390/diagnostics11112078

Challenges of Antibiotic Formulations and Administration in the Treatment of Bloodstream Infections in Children Under Five Admitted to Kisantu Hospital, Democratic Republic of Congo

Autorzy: Bieke Tack, Daniel Vita, Emmanuel Ntangu, Japhet Ngina, Pathy Mukoko, Adèle Lutumba, Dina Vangeluwe, Jaan Toelen, Karel Allegaert, Octavie Lunguya, Raffaella Ravinetto, Jan Jacobs
Opublikowane w: The American Journal of Tropical Medicine and Hygiene, Numer 109, 2023, Strona(/y) 1245-1259, ISSN 0002-9637
Wydawca: American Society of Tropical Medicine and Hygiene
DOI: 10.4269/ajtmh.23-0322

Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS- vaccine studies in endemic countries: Seroepidemiology in Africa of iNTS (SAiNTS) Study Protocol: Malawi site [Version 9.0]

Autorzy: Helen Dale, Esmeda Chirwa, Priyanka Patel, Georgina Makuta, Felistas Mwakiseghile, Theresa Misiri, Innocent Kadwala, Maurice Mbewe, Happy Banda, Niza Silungwe, Kenneth Chizani, Paul Kambiya, Marc Henrion, Neil French, Tonny Nyirenda, Melita Gordon, null null
Opublikowane w: Wellcome Open Research, Numer 8, 2024, Strona(/y) 27, ISSN 2398-502X
Wydawca: F1000 Research Ltd
DOI: 10.12688/wellcomeopenres.18054.2

Epidemiological cut-off value and antibiotic susceptibility test methods for azithromycin in a collection of multi-country invasive non-typhoidal Salmonella

Autorzy: Tack B, Phoba MF, Thong P, Lompo P, Hupko C, Desmet S, Martiny D, Mattheus W, Pardos de la Gandara M, Mbuyi-Kalonji L, Kuijpers L, Prevost B, Barbé B, Vandenberg O, Lunguya O, Ruiz J, Jacobs J, Hardy L.
Opublikowane w: Clin Microbiol Infect., Numer Dec;28(12), 2022, Strona(/y) 1615-1623, ISSN 1469-0691
Wydawca: Elsevier
DOI: 10.1016/j.cmi.2022.06.009

Field Experiences with Handheld Diagnostic Devices to Triage Children under Five Presenting with Severe Febrile Illness in a District Hospital in DR Congo

Autorzy: Bieke Tack, Daniel Vita, Irène Mansosa, Thomas Nsema Mbaki, Naomie Wasolua, Aimée Luyindula, Jaan Toelen, Octavie Lunguya, Jan Jacobs
Opublikowane w: Diagnostics, Numer 12(3), 2022, Strona(/y) 746, ISSN 2075-4418
Wydawca: MDPI
DOI: 10.3390/diagnostics12030746

Other (2)

Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS- vaccine studies in endemic countries: Seroepidemiology in Africa of iNTS (SAiNTS) Study Protocol [Version 9.0]

Autorzy: Melita Gordon; Marc Henrion; Helen Dale
Opublikowane w: Crossref, Numer 2, 2023
Wydawca: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.18054.1

Effectiveness of iNTS vaccination in Sub-Saharan Africa

Autorzy: Cassese, Daniele; Dimitri, Nicola; Breghi, Gianluca; Spadafina, Tiziana
Opublikowane w: Numer 3, 2023
Wydawca: arXiv
DOI: 10.48550/arxiv.2303.18036