DIABFRAIL-LATAM multimodal intervention—combining exercise, education, nutrition, and personalized therapeutic targets—has led to significant improvements in the quality of life and physical function of older adults with diabetes and frailty or pre-frailty. Participants have incorporated healthier habits, especially regular exercise, which is shown to prevent or delay diabetes complications and functional decline. Participants gain a better understanding of diabetes, its management, and self-care practices. The program teaches them to recognize and manage hypoglycemia, malnutrition, and other complications, fostering greater autonomy and confidence in managing their condition. The intervention helps reduce hospitalizations, disability, and the economic burden on health systems and caregivers. DIABFRAIL-LATAM demonstrates that non-drug strategies (exercise, nutrition, education) are essential in the management of older adults with diabetes, supporting a shift in clinical guidelines and public health policies. The intervention is feasible, effective, and now is being scaled up across multiple Latin American countries, with the support of the Pan American Health Organization (PAHO) and local governments, setting a precedent for regional collaboration in chronic disease management. Its methodology, based on WHO and EU recommendations, ensures that the intervention can be adapted and expanded to diverse health systems. DIABFRAIL-LATAM supports global and regional strategies for healthy aging and chronic disease control, aligning with the goals of the Global Alliance for Chronic Diseases, PAHO, WHO, and the European Commission
