Most of the current, state-of the art fragment libraries contain commonly available fragments, based on some thematic selections, such as number of heavy atoms, Florine Fragment library, Bromine-Based Fragment Library, Fsp3-enriched Fragment Library, Fragment Library with Experimental Solubility Data, etc.. The typical size is few thousand compounds and there are only few libraries using 3D data (e.g. Shape Signatures). However, in all cases, suppliers are providing subsets of the library containing multiple closely related alternatives for a given fragment scaffold. On the other hand, the Leap-to-Lead™ Comprehensive Fragment Library (CFL) will provide a 3D physical library of ca. 500 diverse compounds where each molecule represents 1000’s of novel CFL analogues. This concept, as such, is new and revolutionary.
In one hand, the L2L project will be highly beneficial for the pharmaceutical industry, as it will make possible fast, appropriate, and cost-effective selection of high quality lead compounds as starting points of drug discovery. On the other hand, the success of the project will impact our company by enhancing our profitability and growth. Beside the scientific and business impacts of the project, the widespread usage of L2L method will result in accelerated drug discovery, as the lead molecule will be found in less steps and in shorter time. As consequence, drug discovery activities will produce less waste. The faster and cheaper synthesis of drug candidates will lead, eventually, to less costly drugs, which will be an overall societal benefit. Furthermore, the more efficient selection of drug candidates from a broadly represented chemical space may contribute to find drugs for important and yet unmet chronic diseases.
