Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Project Information

INO3D

Grant agreement ID: 833613

DOI

10.3030/833613

Project closed

EC signature date 29 May 2019

Start date 1 October 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 201 875,00

EU contribution

€ 2 201 875,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling

Author(s): Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S.
Published in: Science, 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adf6287

Megadalton chromatin remodelers: common principles for versatile functions.

Author(s): Anna Jungblut; Sebastian Eustermann; Karl-Peter Hopfner
Published in: Current Opinion Struct Biol, Issue 1, 2020, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.06.024

Structural mechanism of extranucleosomal DNA readout by the INO80 complex

Author(s): Franziska Kunert; Felix J. Metzner; James Jung; Markus Höpfler; Stephan Woike; Kevin Schall; Dirk Kostrewa; Manuela Moldt; Jia-Xuan Chen; Susanne Bantele; Boris Pfander; Sebastian Eustermann; Karl-Peter Hopfner
Published in: Science Advances, Issue 1, 2022, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.add3189

A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler

Author(s): Karl, Leonhard A; Galanti, Lorenzo; Bantele, Susanne CS; Metzner, Felix; Šafarić, Barbara; Rajappa, Lional; Foster, Benjamin; Borges Pires, Vanessa; Bansal, Priyanka; Chacin, Erika; Basquin, Jerôme; Duderstadt, Karl E; Kurat, Christoph F; Bartke, Till; Hopfner, Karl-Peter; Pfander, Boris
Published in: Life Science Alliance, Issue 1, 2023, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.202201790

Measuring DNA mechanics on the genome scale

Author(s): Aakash Basu, Dmitriy G. Bobrovnikov, Zan Qureshi, Tunc Kayikcioglu, Thuy T. M. Ngo, Anand Ranjan, Sebastian Eustermann, Basilio Cieza, Michael T. Morgan, Miroslav Hejna, H. Tomas Rube, Karl-Peter Hopfner, Cynthia Wolberger, Jun S. Song, Taekjip Ha
Published in: Nature, Issue 589/7842, 2021, Page(s) 462-467, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-03052-3

Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1

Author(s): Woike S, Eustermann S, Jung J, Wenzl SJ, Hagemann G, Bartho J, Lammens K, Butryn A, Herzog F, Hopfner KP
Published in: Nature Structural & Molecular Biology, 2023, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-00966-0

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

Author(s): Elisa Oberbeckmann, Vanessa Niebauer, Shinya Watanabe, Lucas Farnung, Manuela Moldt, Andrea Schmid, Patrick Cramer, Craig L. Peterson, Sebastian Eustermann, Karl-Peter Hopfner, Philipp Korber
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2020.02.28.969618

Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles

Author(s): Mengtian Ren, Fabian Gut, Yilan Fan, Jingke Ma, Xiajing Shan, Aysenur Yikilmazsoy, Mariia Likhodeeva, Karl-Peter Hopfner, Chuanzheng Zhou
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53811-3

Genome information processing by the INO80 chromatin remodeler positions nucleosomes

Author(s): Elisa Oberbeckmann, Nils Krietenstein, Vanessa Niebauer, Yingfei Wang, Kevin Schall, Manuela Moldt, Tobias Straub, Remo Rohs, Karl-Peter Hopfner, Philipp Korber, Sebastian Eustermann
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2020.11.03.366690

Other (3)

Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex

Author(s): Priyanka Aggarwal, Manmohan Sharma, Stephan Woike, Franziska Kunert, Manuela Moldt, Karl-Peter Hopfner
Published in: BioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.08.25.671740

Sequence- and chemical specificity define the functional landscape of intrinsically disordered regions

Author(s): Iris Langstein-Skora, Andrea Schmid, Frauke Huth, Drin Shabani, Lorenz Spechtenhauser, Mariia Likhodeeva, Franziska Kunert, Felix J. Metzner, Ryan J. Emenecker, Mary O.G. Richardson, Wasim Aftab, Maximilian J. Götz, Sarah K. Payer, Niccoló Pietrantoni, Valentina Sjeničić, Sakthi K. Ravichandran, Till Bartke, Karl-Peter Hopfner, Ulrich Gerland, Philipp Korber, Alex S. Holehouse
Published in: BioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.02.10.480018

Chromatin Protection by the Chromosomal Passenger Complex

Author(s): A. Gireesh, M.A. Abad, R.-S. Nozawa, P. Sotelo-Parrilla, L.C. Dury, M. Likhodeeva, C. Spanos, C. Cardenal Peralta, J. Rappsilber, K.P. Hopfner, M.D. Wilson, W. Vanderlinden, T. Hirota, A.A. Jeyaprakash
Published in: BioRXiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.15.654082