Metabolic crosstalk in the regulation of inflammation

Publikacje

Caspase-4: A Therapeutic Target for Peptic Ulcer Disease

Autorzy: Zbigniew Zaslona, Ewelina Flis, Ciara Nulty, Jay Kearney, Rebecca Fitzgerald, Atiyekeogbebe R. Douglas, Deirdre McNamara, Sinead Smith, Luke A. J. O’Neill, Emma M. Creagh
Opublikowane w: ImmunoHorizons, Numer 4/10, 2020, Strona(/y) 627-633, ISSN 2573-7732
Wydawca: AAI
DOI: 10.4049/immunohorizons.2000080

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.

Autorzy: Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ.
Opublikowane w: Cell Metabolism, 2022, Strona(/y) 487-501, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2022.02.002

Pseudomonas Persists by Feeding off Itaconate

Autorzy: Marah C. Runtsch, Luke A.J. O’Neill
Opublikowane w: Cell Metabolism, Numer 31/6, 2020, Strona(/y) 1045-1047, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2020.05.005

Modification of Proteins by Metabolites in Immunity

Autorzy: Ciana Diskin , Tristram Ryan , L A J O'Neill
Opublikowane w: Immunity, 2021, Strona(/y) 19-31, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2020.09.014

The Immunomodulatory Potential of the Metabolite Itaconate

Autorzy: Alexander Hooftman, Luke A.J. O’Neill
Opublikowane w: Trends in Immunology, Numer 40/8, 2019, Strona(/y) 687-698, ISSN 1471-4906
Wydawca: Elsevier BV
DOI: 10.1016/j.it.2019.05.007

Fumarate hydratase as a metabolic regulator of immunity

Autorzy: Christian G Peace, Shane M O'Carroll and Luke A J O'Neill
Opublikowane w: Trends in Cell Biology, Numer S0962-8924(23)00209-X., 2023, Strona(/y) S0962-8924(23)00209-X., ISSN 1879-3088
Wydawca: Elsevier
DOI: 10.1016/j.tcb.2023.10.005

Daily variation in macrophage phagocytosis is clock‐independent and dispensable for cytokine production

Autorzy: Sarah S. Geiger, Annie M. Curtis, Luke A. J. O'Neill, Richard M. Siegel
Opublikowane w: Immunology, Numer 157/2, 2019, Strona(/y) 122-136, ISSN 0019-2805
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imm.13053

Caspase-11 promotes allergic airway inflammation

Autorzy: Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Opublikowane w: Nature Communications, Numer 11/1, 2020, Strona(/y) monthly, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-14945-2

Protein targeting by the itaconate family in immunity and inflammation

Autorzy: Emily A Day and Luke A J O'Neill
Opublikowane w: Biochemical Journal, Numer 479(24), 2022, Strona(/y) 2499-2510, ISSN 1470-8728
Wydawca: Portland Press
DOI: 10.1042/bcj20220364

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Autorzy: Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark M. Hughes, Alan D. Irvine, Roman Fischer, Luke A.J. O’Neill
Opublikowane w: Cell Metabolism, Numer 32/3, 2020, Strona(/y) 468-478.e7, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2020.07.016

Targetting mitochondria to beat HIV

Autorzy: Emily Day, Luke O'Neill
Opublikowane w: Nature Immunology, 2021, Strona(/y) 398-399, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-021-00881-w

The itaconate family of immunomodulators grows

Autorzy: Anne F McGettrick and Luke A J O'Neill
Opublikowane w: Nature Metabolism, Numer 4(5), 2022, Strona(/y) 499-500, ISSN 2522-5812
Wydawca: Nature Portfolic
DOI: 10.1038/s42255-022-00578-w

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Autorzy: Hooftman A et al and including Emily Day, Juliana E Toller Kawahisa, Tristram Ryan and Luke O'Neill
Opublikowane w: Nature, Numer 615(7952), 2023, Strona(/y) 490-498, ISSN 1476-4687
Wydawca: Nature Portfolio
DOI: 10.1038/s41586-023-05720-6

Targeting immunometabolism as an anti-inflammatory strategy

Autorzy: Eva M. Pålsson-McDermott, Luke A. J. O’Neill
Opublikowane w: Cell Research, Numer 30/4, 2020, Strona(/y) 300-314, ISSN 1001-0602
Wydawca: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0291-z

How should we talk about metabolism?

Autorzy: Michael P. Murphy, Luke A. J. O’Neill
Opublikowane w: Nature Immunology, Numer 21/7, 2020, Strona(/y) 713-715, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-020-0691-8

The next decade of metabolism

Autorzy: Fredrik Bäckhed, Elisabetta Bugianesi, Heather Christofk, Ivan Dikic, Rana Gupta, William B. Mair, Luke A. J. O’Neill, Markus Ralser, David M. Sabatini, Matthias Tschöp
Opublikowane w: Nature Metabolism, Numer 1/1, 2019, Strona(/y) 2-4, ISSN 2522-5812
Wydawca: npg
DOI: 10.1038/s42255-018-0022-7

Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Autorzy: Ryan TAJ, Preston RJS, O'Neill LAJ
Opublikowane w: Biochemical Journal, 2022, Strona(/y) 731-750, ISSN 0264-6021
Wydawca: Portland Press, Ltd.
DOI: 10.1042/bcj20210522

Krebs Cycle Reborn in Macrophage Immunometabolism

Autorzy: Dylan G. Ryan, Luke A.J. O'Neill
Opublikowane w: Annual Review of Immunology, Numer 38/1, 2020, Strona(/y) 289-313, ISSN 0732-0582
Wydawca: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-081619-104850

The Role of HIF in Immunity and Inflammation

Autorzy: Anne F. McGettrick, Luke A.J. O’Neill
Opublikowane w: Cell Metabolism, Numer 32/4, 2020, Strona(/y) 524-536, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2020.08.002

Targeting macrophage immunometabolism to prevent atherosclerosis

Autorzy: Luke A. J. O’Neill
Opublikowane w: Nature Metabolism, Numer 1/12, 2019, Strona(/y) 1173-1174, ISSN 2522-5812
Wydawca: Springer
DOI: 10.1038/s42255-019-0154-4

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1

Autorzy: Pau Ribó-Molina and including Hauke J Weiss and Luke A J O'Neill
Opublikowane w: Journal of Virology, Numer 97(10), 2023, Strona(/y) e0132523, ISSN 1098-5514
Wydawca: American Society for Microbiology
DOI: 10.1128/jvi.01325-23

Cytokine-like Roles for Metabolites in Immunity

Autorzy: Zbigniew Zasłona, Luke A.J. O’Neill
Opublikowane w: Molecular Cell, Numer 78/5, 2020, Strona(/y) 814-823, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2020.04.002

Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice

Autorzy: Stella Liong, Osezua Oseghale, Eunice E. To, Kurt Brassington, Jonathan R. Erlich, Raymond Luong, Felicia Liong, Robert Brooks, Cara Martin, Sharon O’Toole, Antony Vinh, Luke A. J. O’Neill, Steven Bozinovski, Ross Vlahos, Paris C. Papagianis, John J. O’Leary, Doug A. Brooks, Stavros Selemidis
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 117/40, 2020, Strona(/y) 24964-24973, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2006905117

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2

Autorzy: Ciana Diskin, Emily A Day, Órlaith C Henry, Juliana E Toller-Kawahisa , Luke A J O'Neill
Opublikowane w: J Immunol, Numer 211(6), 2023, Strona(/y) 10321041, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.2200848

BCG-induced trained immunity: can it offer protection against COVID-19?

Autorzy: Luke A. J. O’Neill, Mihai G. Netea
Opublikowane w: Nature Reviews Immunology, Numer 20/6, 2020, Strona(/y) 335-337, ISSN 1474-1733
Wydawca: Nature Publishing Group
DOI: 10.1038/s41577-020-0337-y

Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite

Autorzy: Anne F McGettrick Luke AJ O'Neill
Opublikowane w: Current Opinion in Immunology, Numer 80, 2023, Strona(/y) 102268, ISSN 0952-7915
Wydawca: Elsevier BV
DOI: 10.1016/j.coi.2022.102268

Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

Autorzy: Eunice E. To, John J. O'Leary, Luke A.J. O'Neill, Ross Vlahos, Steven Bozinovski, Christopher J.H. Porter, Robert D. Brooks, Doug A. Brooks, Stavros Selemidis
Opublikowane w: Antioxidants & Redox Signaling, Numer 32/13, 2020, Strona(/y) 982-992, ISSN 1523-0864
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2020.8027

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

Autorzy: Stefano Angiari, Marah C. Runtsch, Caroline E. Sutton, Eva M. Palsson-McDermott, Beth Kelly, Nisha Rana, Harry Kane, Gina Papadopoulou, Erika L. Pearce, Kingston H.G. Mills, Luke A.J. O'Neill
Opublikowane w: Cell Metabolism, Numer 31/2, 2020, Strona(/y) 391-405.e8, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2019.10.015

How neutrophil metabolism affects bacterial killing

Autorzy: Juliana E Toller-Kawahisa and Luke A J O'Neill
Opublikowane w: Open Biology, Numer 12(11), 2022, Strona(/y) 220248, ISSN 2046-2441
Wydawca: Royal Society Publishing
DOI: 10.1098/rsob.220248

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

Autorzy: Juliana E Toller-Kawahisa and including Tristram Ryan and Luke O'Neill
Opublikowane w: Nature Communications, Numer 14(1), 2023, Strona(/y) 4280, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-40021-6

The role of itaconate in host defense and inflammation.

Autorzy: Peace C, O'Neill LA
Opublikowane w: J Clin Invest, 2022, Strona(/y) 132(2):e148548, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci148548

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Autorzy: Tristram Ryan and including Juliana E Toller Emily Day Hauke Weiss and Luke O'Neill
Opublikowane w: Nature Communications, Numer 4(1), 2023, Strona(/y) 3513, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-39174-1

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Autorzy: Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board,
Opublikowane w: Cell Reports, Numer 29/1, 2019, Strona(/y) 151-161.e5, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.08.072

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