Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines

Informacje na temat projektu

3DBrainStrom

Identyfikator umowy o grant: 835227

DOI

10.3030/835227

Projekt został zamknięty

Data podpisania przez KE 23 Maja 2019

Data rozpoczęcia 1 Kwietnia 2019

Data zakończenia 31 Marca 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 353 125,00

Wkład UE

€ 2 353 125,00

Koordynowany przez

TEL AVIV UNIVERSITY
Israel

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (29)

Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker

Autorzy: Yulia Liubomirski, Galia Tiram, Anna Scomparin, Samer Gnaim, Sayantan Das, Sachin Gholap, Liang Ge, Eilam Yeini, Omri Shelef, Arie Zauberman, Nir Berger, Doron Kalimi, Mira Toister-Achituv, Christian Schröter, Stephan Dickgiesser, Jason Tonillo, Min Shan, Carl Deutsch, Stanley Sweeney-Lasch, Doron Shabat, Ronit Satchi-Fainaro
Opublikowane w: Journal of Controlled Release, Numer 367, 2024, Strona(/y) 148-157, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2024.01.025

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

Autorzy: João Conniot, Anna Scomparin, Carina Peres, Eilam Yeini, Sabina Pozzi, Ana I. Matos, Ron Kleiner, Liane I. F. Moura, Eva Zupančič, Ana S. Viana, Hila Doron, Pedro M. P. Gois, Neta Erez, Steffen Jung, Ronit Satchi-Fainaro, Helena F. Florindo
Opublikowane w: Nature Nanotechnology, Numer 14, 2023, Strona(/y) 891-901, ISSN 1748-3387
Wydawca: Nature Publishing Group
DOI: 10.1038/s41565-019-0512-0

Immune-mediated approaches against COVID-19

Autorzy: Helena F. Florindo, Ron Kleiner, Daniella Vaskovich-Koubi, Rita C. Acúrcio, Barbara Carreira, Eilam Yeini, Galia Tiram, Yulia Liubomirski, Ronit Satchi-Fainaro
Opublikowane w: Nature Nanotechnology, Numer 15/8, 2020, Strona(/y) 630-645, ISSN 1748-3387
Wydawca: Nature Publishing Group
DOI: 10.1038/s41565-020-0732-3

Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short‐term vs long‐term survivors of glioblastoma

Autorzy: Paula Ofek, Eilam Yeini, Gali Arad, Artem Danilevsky, Sabina Pozzi, Christian Burgos Luna, Sahar Israeli Dangoor, Rachel Grossman, Zvi Ram, Noam Shomron, Henry Brem, Thomas M. Hyde, Tamar Geiger, Ronit Satchi‐Fainaro
Opublikowane w: International Journal of Cancer, Numer 153, 2023, Strona(/y) 654-668, ISSN 0020-7136
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34545

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

Autorzy: Rita C. Acúrcio, Sabina Pozzi, Barbara Carreira, Marta Pojo, Nuria Gómez-Cebrián, Sandra Casimiro, Adelaide Fernandes, Andreia Barateiro, Vitor Farricha, Joaquim Brito, Ana Paula Leandro, Jorge A R Salvador, Luís Graça, Leonor Puchades-Carrasco, Luís Costa, Ronit Satchi-Fainaro, Rita C. Guedes, Helena F. Florindo
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 10, 2024, Strona(/y) e004695, ISSN 2051-1426
Wydawca: BMJ
DOI: 10.1136/jitc-2022-004695

interFLOW: maximum flow framework for the identification of factors mediating the signaling convergence of multiple receptors

Autorzy: Ron Sheinin, Koren Salomon, Eilam Yeini, Shai Dulberg, Ayelet Kaminitz, Ronit Satchi-Fainaro, Roded Sharan, Asaf Madi
Opublikowane w: npj Systems Biology and Applications, Numer 10, 2024, ISSN 2056-7189
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41540-024-00391-z

Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma

Autorzy: Evgeni Pisarevsky, Rachel Blau, Yana Epshtein, Dikla Ben‐Shushan, Anat Eldar‐Boock, Galia Tiram, Shani Koshrovski‐Michael, Anna Scomparin, Sabina Pozzi, Adva Krivitsky, Gal Shenbach‐Koltin, Eilam Yeini, Lidar Fridrich, Richard White, Ronit Satchi‐Fainaro
Opublikowane w: Advanced Therapeutics, Numer 3/8, 2020, Strona(/y) 2000028, ISSN 2366-3987
Wydawca: Wile Online Library
DOI: 10.1002/adtp.202000028

Two-in-one nanoparticle platform induces a strong therapeutic effect of targeted therapies in P-selectin–expressing cancers

Autorzy: Shani Koshrovski-Michael, Daniel Rodriguez Ajamil, Pradip Dey, Ron Kleiner, Shahar Tevet, Yana Epshtein, Marina Green Buzhor, Rami Khoury, Sabina Pozzi, Gal Shenbach-Koltin, Eilam Yeini, Laura Woythe, Rachel Blau, Anna Scomparin, Iris Barshack, Helena F. Florindo, Shlomi Lazar, Lorenzo Albertazzi, Roey J. Amir, Ronit Satchi-Fainaro
Opublikowane w: Science Advances, Numer 10, 2024, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr4762

Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors

Autorzy: Adva Krivitsky, Sabina Pozzi, Eilam Yeini, Sahar Israeli Dangoor, Tal Zur, Sapir Golan, Vadim Krivitsky, Nitzan Albeck, Evgeny Pisarevsky, Paula Ofek, Asaf Madi, Ronit Satchi-Fainaro
Opublikowane w: Pharmaceutics, Numer 13, 2024, Strona(/y) 2199, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122199

Polymeric-based neoantigen nanovaccine synergizes with PD-1/PD-L1 modulators, reprogramming the melanoma microenvironment

Autorzy: Bárbara Carreira, Rita C. Acúrcio, Ana I. Matos, Liane I.F. Moura, Marta B. Afonso, Ana S. Viana, Fábio M.F. Santos, Pedro M.P. Gois, Cecília M.P. Rodrigues, Rita C. Guedes, Ronit Satchi-Fainaro, Helena F. Florindo
Opublikowane w: Journal of Controlled Release, Numer 387, 2025, Strona(/y) 114178, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2025.114178

Polyglutamate-based nanoconjugates for image-guided surgery and post-operative melanoma metastases prevention

Autorzy: Yana Epshtein, Rachel Blau, Evgeni Pisarevsky, Shani Koshrovski-Michael, Dikla Ben-Shushan, Sabina Pozzi, Gal Shenbach-Koltin, Lidar Fridrich, Marina Buzhor, Adva Krivitsky, Pradip Dey, Ronit Satchi-Fainaro
Opublikowane w: Theranostics, Numer 12, 2022, Strona(/y) 6339-6362, ISSN 1838-7640
Wydawca: Ivyspring International Publisher
DOI: 10.7150/thno.72941

Proteogenomics of glioblastoma associates molecular patterns with survival

Autorzy: Gali Yanovich-Arad, Paula Ofek, Eilam Yeini, Mariya Mardamshina, Artem Danilevsky, Noam Shomron, Rachel Grossman, Ronit Satchi-Fainaro, Tamar Geiger
Opublikowane w: Cell Reports, Numer 34, 2022, Strona(/y) 108787, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.108787

Polyoxazoline‐Based Nanovaccine Synergizes with Tumor‐Associated Macrophage Targeting and Anti‐PD‐1 Immunotherapy against Solid Tumors

Autorzy: Ana I. Matos, Carina Peres, Barbara Carreira, Liane I. F. Moura, Rita C. Acúrcio, Theresa Vogel, Erik Wegener, Filipa Ribeiro, Marta B. Afonso, Fábio M. F. Santos, Águeda Martínez‐Barriocanal, Diego Arango, Ana S. Viana, Pedro M. P. Góis, Liana C. Silva, Cecília M. P. Rodrigues, Luis Graca, Rainer Jordan, Ronit Satchi‐Fainaro, Helena F. Florindo
Opublikowane w: Advanced Science, Numer 10, 2023, ISSN 2198-3844
Wydawca: Wiley
DOI: 10.1002/advs.202300299

Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?

Autorzy: Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro
Opublikowane w: Advanced Drug Delivery Reviews, Numer 175, 2021, Strona(/y) 113760, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2021.04.001

IRS2 as a driver of brain metastasis in colorectal cancer: A potential target for novel therapeutic strategies

Autorzy: Inbal Greenberg, Fayhaa Khair-Dabour, Keren Merenbakh-Lamin, Ethan S Sokol, Anat Klein Goldberg, Dor Simkin, Avishay Spitzer, Moshe Benhamou, Shai Bar-Shira, Michal Raz, Rachel Grossman, Eilam Yeini, Paula Ofek, Tomer Meirson, Ronit Satchi-Fainaro, Hadas Reuveni, Ido Wolf, Tami Rubinek
Opublikowane w: Neuro-Oncology, Numer 27, 2025, Strona(/y) 1729-1745, ISSN 1522-8517
Wydawca: Duke University Press
DOI: 10.1093/neuonc/noaf028

3D bioprinted cancer models: from basic biology to drug development

Autorzy: Lena Neufeld, Eilam Yeini, Sabina Pozzi, Ronit Satchi-Fainaro
Opublikowane w: Nature Reviews Cancer, Numer 22, 2022, Strona(/y) 679-692, ISSN 1474-175X
Wydawca: Nature Publishing Group
DOI: 10.1038/s41568-022-00514-w

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Autorzy: Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro
Opublikowane w: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202503198

Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy

Autorzy: Rami Khoury, Giuseppe Longobardi, Tania T. Barnatan, Dana Venkert, América García Alvarado, Adi Yona, Marina Green Buzhor, Shir Shahar, Qiwei Wang, Rita C. Acúrcio, Rita C. Guedes, Helena F. Florindo, Jean J. Zhao, Ronit Satchi-Fainaro
Opublikowane w: Journal of Controlled Release, Numer 383, 2025, Strona(/y) 113812, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113812

Chemiluminescent probes in cancer biology

Autorzy: Rachel Blau, Omri Shelef, Doron Shabat, Ronit Satchi-Fainaro
Opublikowane w: Nature Reviews Bioengineering, Numer 1, 2023, Strona(/y) 648-664, ISSN 2731-6092
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44222-023-00074-0

CCL2 blockade combined with PD-1/P-selectin immunomodulators impedes breast cancer brain metastasis

Autorzy: Sahar Israeli Dangoor, Rami Khoury, Koren Salomon, Sabina Pozzi, Shir Shahar, Adan Miari, Yael Leichtmann-Bardoogo, Neta Bar-Hai, Neta Frommer, Eilam Yeini, Tom Winkler, Nora Balint Lahat, Iris Kamer, Ori Hadad, Kathrin Laue, Henry Brem, Thomas M Hyde, Jair Bar, Iris Barshack, Uri Ben-David, Dana Ishay-Ronen, Ben M Maoz, Ronit Satchi-Fainaro
Opublikowane w: Brain, Numer 148, 2025, Strona(/y) 1740-1756, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awae347

Better, Faster, Stronger: Accelerating <scp>mRNA</scp>‐Based Immunotherapies With Nanocarriers

Autorzy: Henrique M. B. Carvalho, Tiago A. S. Fidalgo, Rita C. Acúrcio, Ana I. Matos, Ronit Satchi‐Fainaro, Helena F. Florindo
Opublikowane w: WIREs Nanomedicine and Nanobiotechnology, Numer 16, 2025, ISSN 1939-0041
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/wnan.2017

Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 Immunotherapy

Autorzy: Rita C. Acúrcio, Ron Kleiner, Daniella Vaskovich‐Koubi, Bárbara Carreira, Yulia Liubomirski, Carolina Palma, Adva Yeheskel, Eilam Yeini, Ana S. Viana, Vera Ferreira, Carlos Araújo, Michael Mor, Natalia T. Freund, Eran Bacharach, João Gonçalves, Mira Toister‐Achituv, Manon Fabregue, Solene Matthieu, Capucine Guerry, Ana Zarubica, Sarit Aviel‐Ronen, Helena F. Florindo, Ronit Satchi‐Fain
Opublikowane w: Advanced Science, Numer 11, 2024, ISSN 2198-3844
Wydawca: Wiley
DOI: 10.1002/advs.202404159

Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Autorzy: Lena Neufeld, Eilam Yeini, Noa Reisman, Yael Shtilerman, Dikla Ben-Shushan, Sabina Pozzi, Asaf Madi, Galia Tiram, Anat Eldar-Boock, Shiran Ferber, Rachel Grossman, Zvi Ram, Ronit Satchi-Fainaro
Opublikowane w: Science Advances, Numer 7/34, 2021, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.abi9119

Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment

Autorzy: Barbara Carreira, Rita C. Acúrcio, Ana I. Matos, Carina Peres, Sabina Pozzi, Daniella Vaskovich‐Koubi, Ron Kleiner, Mariana Bento, Ronit Satchi‐Fainaro, Helena F. Florindo
Opublikowane w: Advanced Therapeutics, Numer 4, 2024, ISSN 2366-3987
Wydawca: Wiley
DOI: 10.1002/adtp.202000147

Patient-Derived 3D-Bioprinted Models of Pancreatic Cancer: Toward Personalized Therapy and Overcoming Tumor Microenvironment Challenges

Autorzy: Daniella Vaskovich-Koubi, Marina Green Buzhor, Anne Krinsky, Yair Roth, Koren Salomon, Ron Kleiner, Rina Sevostianov, Ohad Hasin, Rami Khoury, Ronit Satchi-Fainaro
Opublikowane w: Advanced Drug Delivery Reviews, Numer 225, 2025, Strona(/y) 115670, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2025.115670

Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Autorzy: Lena Neufeld, Eilam Yeini, Noa Reisman, Yael Shtilerman, Dikla Ben-Shushan, Sabina Pozzi, Asaf Madi, Galia Tiram, Anat Eldar-Boock, Shiran Ferber, Rachel Grossman, Zvi Ram, Ronit Satchi-Fainaro
Opublikowane w: Science Advances, Numer 7, 2024, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abi9119

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

Autorzy: Eilam Yeini, Paula Ofek, Sabina Pozzi, Nitzan Albeck, Dikla Ben-Shushan, Galia Tiram, Sapir Golan, Ron Kleiner, Ron Sheinin, Sahar Israeli Dangoor, Shlomit Reich-Zeliger, Rachel Grossman, Zvi Ram, Henry Brem, Thomas M. Hyde, Prerna Magod, Dinorah Friedmann-Morvinski, Asaf Madi, Ronit Satchi-Fainaro
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-22186-0

Thymidine Phosphodiester Chemiluminescent Probe for Sensitive and Selective Detection of Ectonucleotide Pyrophosphatase 1

Autorzy: Omri Shelef, Sara Gutkin, Molhm Nassir, Anne Krinsky, Ronit Satchi-Fainaro, Phil S. Baran, Doron Shabat
Opublikowane w: Bioconjugate Chemistry, Numer 36, 2025, Strona(/y) 152-159, ISSN 1043-1802
Wydawca: American Chemical Society
DOI: 10.1021/acs.bioconjchem.4c00454

MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression

Autorzy: Sabina Pozzi, Anna Scomparin, Dikla Ben-Shushan, Eilam Yeini, Paula Ofek, Alessio D. Nahmad, Shelly Soffer, Ariel Ionescu, Antonella Ruggiero, Adi Barzel, Henry Brem, Thomas M. Hyde, Iris Barshack, Sanju Sinha, Eytan Ruppin, Tomer Weiss, Asaf Madi, Eran Perlson, Inna Slutsky, Helena F. Florindo, Ronit Satchi-Fainaro
Opublikowane w: JCI Insight, Numer 7, 2023, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.154804

Other (1)

Inactivation of p53 drives breast cancer brain metastasis by altering fatty acid metabolism

Autorzy: Kathrin Laue, Sabina Pozzi, Yael Cohen-Sharir, Tom Winkler, Yonatan Eliezer, Sahar Israeli Dangoor, Alicia I. Leikin-Frenkel, Katharina Lange, Johanna Zerbib, Alessia A. Ricci, Andrea Sacconi, Jean Berthelet, Alexander Schäffer, Wei Shi, Yang Liao, Iris Barshack, Hind Medyouf, Delphine Merino, Giovanni Blandino, Luca Bertero, Ronit Satchi-Fainaro, Uri Ben-David
Opublikowane w: 2023
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.12.20.572490