Projektbeschreibung
Maßgeschneiderte Gewebegerüste aus dem Drucker
Ähnlich wie Baugerüste beim Bau eines Bürogebäudes helfen Gewebegerüste den Zellen dabei, funktionale Gewebe zur Behebung von Krankheiten oder Reparatur von Verletzungen zu bilden. Zur Unterstützung des Zellwachstums und der Gewebebildung konzipierte Gewebegerüste sind mikroskopisch klein, oft nanostrukturiert und müssen biokompatibel sein. Das Projekt BioSMaLL passt mit Unterstützung der Marie-Skłodowska-Curie-Maßnahmen ein neuartiges 3D-Druckverfahren mit der Bezeichnung Solution Mask Liquid Lithography (SMaLL) an funktionelle Biopolymere und Gewebezüchtung an. SMaLL setzt photoaktive Moleküle ein, um die Polymerisation zu steuern und neuartige 3D-Strukturen mit chemisch und mechanisch unterschiedlichen Arealen zu erzeugen. Ergebnis dessen werden verbesserte maßgeschneiderte und biologisch inspirierte Gewebeimplantate für eine Vielzahl biomedizinischer Anwendungen sein.
Ziel
Three-dimensional (3D) printing in biomedical science has recently advanced the development of tailor-made implants. Designing structural and functional 3D constructs mimetic of both tissues and organs offers a genuine route to personalised implants, improving the patients' quality of life and reducing healthcare costs. While engineers have significantly progressed 3D printing methods, the barriers to progress include the limited variety of printable materials as well as the need for alternative low-cost printing technologies. BioSMaLL aims to address this through combining Solution Mask Liquid Lithography (SMaLL), a recent technology developed at the University of California Santa Barbara (UCSB), with the expertise of the applicant and the Royal College of Surgeons in Ireland (RCSI) in functional biopolymers and tissue engineering to develop bio-active scaffolds. The objectives of this global fellowship will be achieved by adaptation of BioSMaLL for newly designed biopolymers during the outgoing phase at UCSB . In a transfer of knowledge, BioSMaLL will then be established at RCSI and bespoke biocompatible scaffolds produced and validated during the incoming phase. The innovative approach will be facilitated by an interdisciplinary methodology at the interface of polymer chemistry, (bio)materials science, 3D printing and tissue engineering in two world-renowned groups. The career goal of the fellow to embark on a career in emerging biomedical technologies in a start-up company will be facilitated by a dedicated training programme across scientific methods as well as complementary training at UCSB and RCSI covering leadership, project management and commercialisation in addition to meetings with laboratory and management staff of the start-up company SurgaColl. The partners have a proven track record in training future leaders in materials science and healthcare aiming to make a difference and establish new technologies and innovative processes in Europe and beyond.
Wissenschaftliches Gebiet
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Aufforderung zur Vorschlagseinreichung
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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Koordinator
2 Dublin
Irland