Descrizione del progetto
Verso impalcature per tessuti su misura
Proprio come le impalcature per costruzioni aiutano a costruire un edificio, così le impalcature per tessuti aiutano le cellule a formare tessuti funzionali per il trattamento di malattie o lesioni. Progettate per favorire la crescita cellulare e la formazione di tessuti, le impalcature per tessuti sono microscopiche, spesso nanostrutturate e devono essere biocompatibili. Con il supporto del programma Marie Skłodowska-Curie, BioSMaLL sta integrando un nuovo metodo di stampa 3D denominato SMaLL (acronimo per Solution Mask Liquid Lithography) con biopolimeri funzionali e ingegneria tissutale. La SMaLL sfrutta molecole fotoattive per controllare la polimerizzazione e creare nuove strutture 3D con domini chimicamente e meccanicamente distinti. Il risultato sarà un miglioramento degli impianti tissutali su misura e bio-ispirati per una varietà di applicazioni biomediche.
Obiettivo
Three-dimensional (3D) printing in biomedical science has recently advanced the development of tailor-made implants. Designing structural and functional 3D constructs mimetic of both tissues and organs offers a genuine route to personalised implants, improving the patients' quality of life and reducing healthcare costs. While engineers have significantly progressed 3D printing methods, the barriers to progress include the limited variety of printable materials as well as the need for alternative low-cost printing technologies. BioSMaLL aims to address this through combining Solution Mask Liquid Lithography (SMaLL), a recent technology developed at the University of California Santa Barbara (UCSB), with the expertise of the applicant and the Royal College of Surgeons in Ireland (RCSI) in functional biopolymers and tissue engineering to develop bio-active scaffolds. The objectives of this global fellowship will be achieved by adaptation of BioSMaLL for newly designed biopolymers during the outgoing phase at UCSB . In a transfer of knowledge, BioSMaLL will then be established at RCSI and bespoke biocompatible scaffolds produced and validated during the incoming phase. The innovative approach will be facilitated by an interdisciplinary methodology at the interface of polymer chemistry, (bio)materials science, 3D printing and tissue engineering in two world-renowned groups. The career goal of the fellow to embark on a career in emerging biomedical technologies in a start-up company will be facilitated by a dedicated training programme across scientific methods as well as complementary training at UCSB and RCSI covering leadership, project management and commercialisation in addition to meetings with laboratory and management staff of the start-up company SurgaColl. The partners have a proven track record in training future leaders in materials science and healthcare aiming to make a difference and establish new technologies and innovative processes in Europe and beyond.
Campo scientifico
Parole chiave
Programma(i)
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Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
2 Dublin
Irlanda