Descrizione del progetto
Nanomacchine come nuovi agenti antimicrobici
La resistenza agli antimicrobici rappresenta uno dei principali problemi di salute a livello globale e necessita dello sviluppo di antibiotici innovativi. Le nanomacchine molecolari sono molecole organiche sintetiche che possono penetrare bistrati lipidici attraverso un movimento rotatorio e sono emerse come promettenti alternative agli antimicrobici. Il progetto REBELLION, finanziato dall’UE, propone di sintetizzare e analizzare le nanomacchine molecolari che rispondono alla luce. Gli scienziati valuteranno le molecole candidate per la loro efficacia contro una serie di bersagli microbici e per la sicurezza nelle cellule di mammifero. Oltre a una maggiore selettività, questi antimicrobici innovativi dimostreranno un inferiore potenziale di sviluppo di resistenza antimicrobica.
Obiettivo
Antimicrobial resistance (AMR) has been identified as a major threat to mankind in the 21st century. Thus, there is a critical need to develop new antimicrobials and new delivery strategies to preserve the viability of the existing antibiotics. One such strategy is the use of molecular nanomachines (MNMs) for targeted and controlled inactivation of bacterial pathogens.
REBELLION aims to develop new light responsive MNMs against bacterial pathogens with minimal damage to mammalian tissues. This strategy will provide a therapeutic advantage in terms of efficacy and selectivity compared with current therapeutics while minimizing the potential for the development of AMR.
The proposed research programme combines (1) chemical synthesis of new MNMs, (2) assessment of their efficacy against clinically relevant bacterial pathogens, (3) evaluation of their safety to mammalian cells and (4) in vivo efficacy testing. The results obtained have the potential to lead to an alternative, entirely novel class of antimicrobials (MNMs) and to become a stepping stone towards future clinical trials.
REBELLION is a vital, multidisciplinary and international endeavor that will bring together this fellow’s core expertise in microbial photobiology with (1) antibiotic resistance and infection at IdISBa (beneficiary, Spain), (2) state-of-the-art technology in light-driven antimicrobial therapy, and experience in in vitro and in vivo drug efficacy testing championed by GAMA Therapeutics (host, USA) and (3) expert knowledge in nanomachine synthesis by the Nanotechnology Department of Rice University (co-host, USA).
I will be trained by top-level scientists and widen my network and competencies through advanced training in nanotechnology, infection, and drug development and testing. This action will catalyze my career into an independent and mature researcher with an eclectic skill set geared toward producing a unique contribution to European excellence in antimicrobial discovery technology.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- engineering and technologynanotechnology
- social sciencespolitical sciencespolitical transitionsrevolutions
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Parole chiave
Programma(i)
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Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
07120 Palma
Spagna