Descrizione del progetto
Ecografia a super-risoluzione degli eritrociti
L’obiettivo del progetto SURE, finanziato dall’UE, è quello di sviluppare e ricercare un metodo di imaging ecografico 3D a super-risoluzione in grado di visualizzare il flusso capillare nel corpo umano. L’approccio consentirà di seguire il movimento dei singoli eritrociti per la visualizzazione completa dell’anatomia, del flusso e della perfusione. L’imaging 3D a super-risoluzione viene eseguito senza agenti di contrasto ed è 2 600 volte più veloce dei metodi attuali. Con questo metodo si otterrà una risoluzione isotropica di 50 micrometri in tutte le direzioni, mentre la risoluzione volumetrica sarà 100-400 volte migliore di quella dello stato dell’arte attuale dell’ecografia 3D. La ricerca si concluderà con gli studi clinici condotti su roditori e soggetti umani per studiare i cambiamenti nella perfusione per il diabete e il cancro.
Obiettivo
"The SURE project: ""Super resolution Ultrasound Real time imaging of Erythrocytes"" will develop and research a new super resolution ultrasound imaging method capable of resolving capillary flow in the human body. The approach tracks the motion of the individual red blood cells (erythrocytes) in a three-dimensional volume for a full visualization of anatomy, flow, and perfusion in a volume down to 13 cm at 20 volumes per second. The super resolution imaging is performed without using contrast agents and is thereby 2600 times faster than current methods. The method has an isotropic resolution of 50 micrometer in all directions, and the volumetric resolution is thereby 100-400 times better than current state-of-the-art 3-D ultrasound imaging. These highly ambitious goals are attained in a synergistic research effort combing four research groups. The scientific project includes breakthroughs in silicon row-column probes with 1 million elements, advanced synthetic aperture ultrafast coded imaging, deep learning for detecting and tracking of cells, pressure gradient estimation, and visualization and quantification of several hundreds of Gbytes volumetric data. The research finally leads to clinical trials conducted on rodents and humans for studying the changes in perfusion for diabetes and cancer. The SURE imaging approach can yield a paradigm shift in the scientific study, diagnoses, and treatment of cancer, diabetes, and vascular disease at the capillary level, as it enables the possibility of volumetric visualizing capillary perfusion in real-time at frame rates above 20 Hz without injection of contrast agents. Imaging is performed using ultrasound at normal diagnostic levels with no known adverse effects and can, thus, be used on a wide range of the population from newborns to the elderly for both diagnosis and repeated screening."
Campo scientifico
- medical and health sciencesbasic medicineanatomy and morphology
- medical and health sciencesclinical medicineangiologyvascular diseases
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesacousticsultrasound
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
ERC-SyG - Synergy grantIstituzione ospitante
2800 Kongens Lyngby
Danimarca