In this period, first and second-generation molecular machines and motors have been designed successfully by ESR1, ESR2, and ESR3. The detailed analytical characterization of the obtained molecular machines and motors has been done by using different analytical techniques. The modification of these machines and motors with sequence-controlled block glycopolymers prepared by ESR4 and ESR5 is still carried out. Afterwards, this sugar modified molecular machines and motors will be tested for specific cell targeting. The enzyme catalase stomatocytes with directional and rotational control have been developed and analyzed by ESR6 and ESR7. The surface decorations of these polymersome and stomatocytes with molecular machines and glycopolymers are still in progress. ESR8 has been using a microfluidic system to prepare different functional artificial cells. ESR9 who is in close collaboration with ESR6 and ESR7 prepared different types of polymeric materials to create bowl-shaped polymersomes and stomatocytes. Amphiphilic polymers have been synthesized and converted to nanoparticles successfully by ESR10 for potential use in drug and gene delivery. Furthermore, the biophysical properties of lipid-based membranes have been analyzed using DNA origami technology by ESR11. The first results were published in an open access scientific journal. ESR12 has succeeded to encapsulate different artificial organelles in larger polymer compartments in order to investigate their activities in the cell environment. The manuscript is under preparation to publish in a scientific journal, too. Additionally, ESR13 succeeded in generating two mitochondrially-targeted polypeptide-based drug delivery platforms in this period. Concerning the compounds with a theoretical endocytic pathway, the preliminary results provide evidence for the mitochondrial colocalization of our trivalent compound and suggest that triphenyl phosphonium (TPP) provided better targeting of polyornithine (PLO) than SS31 peptide. A library of liposome formulations to optimize the stability, uptake, location and RNA transfection were designed by ESR14 and also glycopolymers were incorporated to these liposomes to increase their cell selectivity. ESR15 is carrying out an industrial-based PhD on the implementation of efficient controlled polypeptide-based carrier synthesis under validated technologies. The synthesis of hydroxyproline NCA was scaled up successfully by two-step reaction with diphosgene and cyclization. Regarding the dissemination and exploitation activities, the first dissemination and exploitation plan of the BIOMOLMACS project has been designed. The social media accounts such as, facebook, twitter, Instagram, etc. were opened and used actively. The training lectures were posted on these social media accounts to access everyone. The training courses were captured and uploaded on the project website. They are made openly available on the project website and YouTube channel dedicate to BIOMOLMACS project. The first scientific data was published as an open-access research article on The Journal of Physical Chemistry B. All ESRs prepared short videos to describe their projects, show their facilities and working environments. These videos were uploaded on the BIOMOLMACS website, Instagram and YouTube channel.