Descrizione del progetto
Un'innovativa rete di formazione spera di elaborare nuove strategie per la prevenzione dei tumori comuni
Due fattori importanti che incidono sul rischio di sviluppare il cancro sono l’infiammazione cronica e i livelli di ormoni sessuali in circolo. Più di 150 anni fa, gli scienziati hanno osservato la presenza di cellule infiammatorie nel tumore e che i tumori si manifestano nei siti di infiammazione cronica, dando luogo a un presunto legame tra i due fenomeni. Oggi, anni di studi epidemiologici suggeriscono che fino a un quarto dei casi di cancro siano dovuti a infezione cronica o ad altri tipi di infiammazione cronica. Inoltre, è ora nota una forte correlazione tra i livelli di ormoni sessuali in circolo e il cancro dell’apparato riproduttivo femminile. Il progetto CANCERPREV sta formando giovani ricercatori in tecniche sperimentali e matematiche all'avanguardia, al fine di sviluppare nuove linee guida volte alla prevenzione di tumori associati ad organi riproduttivi e non riproduttivi.
Obiettivo
Incidence and prevalence of many cancer types are significantly increasing worldwide, with substantial differences between the sexes. Environmental influences in concert with genetic and epigenetic factors are still poorly understood.
Simultaneously, more sophisticated and expensive treatments cannot be afforded by society, increasing urgency of efforts in cancer prevention.
CANCERPREV is an innovative interdisciplinary research and training program gathering seven academic beneficiaries and nine partner organizations : (one leading pharmaceutical company, one leading technology company, a health insurance, an internationally known nursing school, three foundations and two universities) in nine European countries. CANCERPREV aims to establish new strategies in cancer prevention, with a focus on two key determinants of cancer risk: sex hormone signaling and chronic inflammation, in breast and skin as benchmarks of early steps of cancer development in organs with reproductive and non-reproductive functions, respectively.
Fifteen Early Stage Researchers (ESRs) will benefit from the complementary expertise of participating organizations and Principal Investigators in: basic cancer research, xenografts and genetic mouse models, bioinformatics and mathematical algorithms, epidemiology / human genetics, biomarkers, pharmacological approaches, behavioral / societal issues and outreach.
This network provides ESRs with unique future career opportunities in both academic and private sectors, through research training for PhD thesis projects with secondments and short and long visits to other participating research institutions, and yearly courses / formal lectures on various aspects of cancer prevention, including global health and occupational / behavioral issues. CANCERPREV will ensure that more knowledge and ideas are converted into products and services, and that a new generation of scientists is trained to contribute to the knowledge-based economy and society.
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
1015 Lausanne
Svizzera