Periodic Reporting for period 1 - NEUcrest (Training European Experts in Multiscale Studies of Neural Crest Development and Disorders: from Patient to Model Systems and Back again.)
Okres sprawozdawczy: 2019-11-01 do 2021-10-31
The aim of the NEUcrest project is to train 15 creative and innovative ESRs within a novel, ambitious and interdisciplinary research program, which main objectives are the following:
1. To undertake an integrated gene discovery approach in NC development and neurocristopathies;
2. To establish cellular and animal models of neurocristopathies with complementary experimental advantages while implementing ethical recommendations;
3. To analyse the role of genes involved in human neurocristopathies with optimised integrative strategies;
4. To establish reciprocal links between clinical genetics and functional studies of neurocristopathies
5. To establish biostatistical strategies tailored for NC gene network computational modelling;
6. To optimize NC differentiation from human stem cells in order to reach industrial standards;
7. To establish the best translational strategies for drug screening in NC-related diseases;
8. To disseminate results for implementation of best practices for molecular diagnostic management strategies;
9. To increase awareness about neurocristopathies in the general public.
Neurocristopathies include dramatic anomalies (craniofacial and other malformations) that have a strong impact on the life of affected individuals. Society’s awareness of these diseases is slowly rising, but the acceptance of handicap in everyday life still requires education. The recent movie « Wonder», about a child bearing the Treacher Collins neurocristopathy exemplifies this hesitatingly emerging consciousness. Addressing affected patients and patient’s families requires dedicated training. NEUcrest aims to offer a unique opportunity to the 15 young scientists to learn how to present their research to different audiences, from teenagers to patients, from academic science actors to industrialists. Together the NEUcrest network will provide new and synthetic data to a wide range of professionals and to patients and public