The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo
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Autori:
Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao , Esther Mahabir, Hisham Bazzi, Alvaro Rada-Iglesias
Pubblicato in:
Nature Communications, 2021, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-021-24641-4
Protocol to study sufficiency of cis-regulatory elements in mouse embryonic stem cells using a CRISPR-mediated knockin approach
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Autori:
Tomas Pachano, Alvaro Rada-Iglesias
Pubblicato in:
STAR Protocols, 2022, ISSN 2666-1667
Editore:
New York: Cell Press Elsevier Inc.
DOI:
10.1016/j.xpro.2022.101492
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
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Autori:
Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo, Maria Mariner-Faulí, Tore Bleckwehl, Helena G Asenjo, Patricia Respuela, Sara Cruz-Molina, María Muñoz-San Martín , Endika Haro, Wilfred F J van IJcken, David Landeira, Alvaro Rada-Iglesias
Pubblicato in:
Nature Genetics, 2021, ISSN 1061-4036
Editore:
Nature Publishing Group
DOI:
10.1038/s41588-021-00888-x
Enhancer-associated H3K4 methylation safeguards in vitro germline competence
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Autori:
Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik & Álvaro Rada-Iglesias
Pubblicato in:
Nature Communications, 2021, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-021-26065-6
Enhancer-gene specificity in development and disease.
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Autori:
Tomás Pachano , Endika Haro, Alvaro Rada-Iglesias
Pubblicato in:
Development, 2022, ISSN 0950-1991
Editore:
The Company of Biologists Ltd.
DOI:
10.1242/dev.186536
