SeCoIIA aims at securing digital transition of manufacturing industry towards more connected, collaborative, flexible and automated production techniques. It fosters user-driven application cases from aeronautics, automotive and naval construction sectors. Collaboration is considered from Organization to Organization (O2O), but also from Machine to Machine (M2M), Machine to Human (M2H) and Human to Human (H2H) perspectives. Enhanced process monitoring, optimization and control is achieved by intelligent use digital twin technology, Industrial IoT, Cloud Manufacturing (CMfg), collaborative robotics and Industrial AI. While enabling enhanced industrial performance, these techniques tend to increase exposure to cyber-threats and should not be deployed without due consideration for Preparedness, Information Security, Process Safety and Liability. These are the challenges that SeCoIIA intends to address through the development of 12 key capabilities which will be assessed in various configurations through 3 ambitious demonstration campaigns lead by pilot users. With 4 large strategic industry players, 4 highly innovative SMEs and 4 highly recognized research centers, SeCoIIA consortium is best suited to achieve enhanced competitiveness and resilience for European manufacturing industry.