Descrizione del progetto
Substrati stampati in 3D per la rigenerazione ossea
La ricostruzione ossea rappresenta una sfida sanitaria significativa con autotrapianti non adatti per difetti ossei di grandi dimensioni e alloinnesti complicati da rigetti immunitari. Il progetto SBR, finanziato dall’UE, sta sviluppando un approccio all’impianto intelligente per un ripristino controllabile e veloce. La soluzione proposta prevede la creazione di substrati polimerici di qualità medica stampati in 3D con cellule staminali e fattori bioattivi incorporati e personalizzati per la patologia e la fisiologia del paziente. Inoltre, il design del substrato consentirà l’aggiunta di diversi sensori per il monitoraggio delle prestazioni dell’impianto basati su inchiostri di stampa 3D conduttivi biocompatibili. Il progetto testerà infine la prova di concetto in vivo in studi con modelli di grandi animali e svilupperà inoltre la strategia normativa e di commercializzazione per i futuri test clinici.
Obiettivo
The management and reconstruction of bone defects is a significant global healthcare challenge. While autografts offer ideal compatibility, they are often not suitable for large bone defects, and allografts suffer from potential immunorejection.The limited efficacy of conventional treatment strategies for large bone defects and the increasing aged population, has inspired the consortium to propose a SMART RESORBABLE BONE (SRB) IMPLANT embedding stem cells and bioactive agents with the aim of a controllable and fast restoration. The proposed solution includes 3D printed medical grade polymers enriched with electrospun fibers (for increased mechanical properties) that can be customized for patient physiology, pathology, and gender. The scaffold design will ensure easy and minimal Injury placement, and will embed different sensors for monitoring e.g. pressure, pH value and temperature based on biocompatible conductive inks. The smart implant will thus be able to provide vital information of implant performance in terms of bone growth and infection/inflammation. The proposed method is unique because it includes a customized smart implant (3D printed parts with adjustable sensors and communication electronic system), together with tissue engineering methods i.e. in-vitro programming of stem cells for embedding into the smart implant. The proposed solution introduces an innovative regenerative chain, from early testing and characterization (identification/adjustement of the proper specifications) and embedding regenerative stem cells and particulate bioactive agents into the smart implant in preclinical research (in-vitro). The in vivo proof of concept of SBR solution will be tested in (large animal model) preclinical studies within the scope of the project. Finally the regulatory and commercialization strategy on how to further explore the proposed concept and deliver it for clinical testing will be elaborated.
Campo scientifico
- medical and health sciencesmedical biotechnologytissue engineering
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health sciencesbasic medicinepathology
- medical and health sciencesmedical biotechnologyimplants
Parole chiave
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SC1-2019-Single-Stage-RTD
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
265 04 Rio Patras
Grecia