Linking within-host and between-host evolution of multidrug-resistant Mycobacterium tuberculosis

Informazioni relative al progetto

ECOEVODRTB

ID dell’accordo di sovvenzione: 883582

DOI

10.3030/883582

Data della firma CE 24 Luglio 2020

Data di avvio 1 Agosto 2020

Data di completamento 31 Gennaio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history.

Autori: Mireia Coscolla; Daniela Brites; Daniela Brites; Fabrizio Menardo; Fabrizio Menardo; Chloé Loiseau; Chloé Loiseau; Sonia Borrell; Sonia Borrell; Isaac Darko Otchere; Adwoa Asante-Poku; Prince Asare; Leonor Sánchez-Busó; Leonor Sánchez-Busó; Florian Gehre; C. N’Dira Sanoussi; Martin Antonio; Affolabi Dissou; Paula Ruiz-Rodríguez; Janet A. M. Fyfe; Erik C. Böttger; Patrick Becket; Stefan N
Pubblicato in: Microbial Genomics, Numero 2, 2021, ISSN 2057-5858
Editore: Microbial Society
DOI: 10.17863/cam.64924

Expression Dysregulation as a Mediator of Fitness Costs in Antibiotic Resistance

Autori: Trauner A, Banaei-Esfahani A, Gygli SM, Warmer P, Feldmann J, Zampieri M, Borrell S, Collins BC, Beisel C, Aebersold R, Gagneux S.
Pubblicato in: Antimicrob Agents Chemother, 2021, ISSN 0021-9193
Editore: American Society for Microbiology
DOI: 10.1128/aac.00504-21

Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study

Autori: Galo A Goig, Fabrizio Menardo, Zubeida Salaam-Dreyer, Anzaan Dippenaar, Elizabeth M Streicher, Johnny Daniels, Anja Reuter, Sonia Borrell, Miriam Reinhard, Anna Doetsch, Christian Beisel, Robin M Warren, Helen Cox, Sebastien Gagneux
Pubblicato in: The Lancet Microbe, Numero 4, 2023, Pagina/e e506-e515, ISSN 2666-5247
Editore: Elsevier
DOI: 10.1016/s2666-5247(23)00110-6

Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv.

Autori: C. N’Dira Sanoussi; C. N’Dira Sanoussi; Mireia Coscolla; Boatema Ofori-Anyinam; Isaac Darko Otchere; Martin Antonio; Stefan Niemann; Julian Parkhill; Julian Parkhill; Simon R. Harris; Dorothy Yeboah-Manu; Sebastien Gagneux; Sebastien Gagneux; Leen Rigouts; Leen Rigouts; Dissou Affolabi; Bouke C. de Jong; Conor J. Meehan; Conor J. Meehan
Pubblicato in: Microbial Genomics, Numero 2, 2021, ISSN 2057-5858
Editore: Microbiology Society
DOI: 10.1099/mgen.0.000437

HIV co-infection is associated with reduced<i>Mycobacterium tuberculosis</i>transmissibility in sub-Saharan Africa

Autori: Etthel M. Windels, Eddie M. Wampande, Moses L. Joloba, W. Henry Boom, Galo A. Goig, Helen Cox, Jerry Hella, Sonia Borrell, Sebastien Gagneux, Daniela Brites, Tanja Stadler
Pubblicato in: PLoS Pathogens, 2023, ISSN 1553-7374
Editore: PLOS
DOI: 10.1101/2023.09.12.557301

Developing customized stepwise MIRU-VNTR typing for tuberculosis surveillance in Georgia

Autori: Nino Maghradze; Levan Jugheli; Sonia Borrell; Nestani Tukvadze; Russell R. Kempker; Henry M. Blumberg; Sebastien Gagneux
Pubblicato in: PLoS One, Numero 1, 2022, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.5451/unibas-ep90637

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim

Autori: Fabrizio Menardo; Fabrizio Menardo; Liliana K. Rutaihwa; Liliana K. Rutaihwa; Michaela Zwyer; Michaela Zwyer; Sonia Borrell; Sonia Borrell; Iñaki Comas; Emilyn Costa Conceição; Emilyn Costa Conceição; Mireia Coscolla; Helen Cox; Moses Joloba; Horng-Yunn Dou; Julia Feldmann; Julia Feldmann; Lukas Fenner; Lukas Fenner; Lukas Fenner; Janet A. M. Fyfe; Qian Gao; Darío García de Viedma; Alberto
Pubblicato in: F1000Research, Numero 1, 2021, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.28318.2

Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study

Autori: Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, Reinhard M, Skrivankova V, Hömke R, Sander P, Avihingsanon A, Abimiku AG, Marcy O, Collantes J, Carter EJ, Wilkinson RJ, Cox H, Yotebieng M, Huebner R, Fenner L, Böttger EC, Gagneux S, Egger M.
Pubblicato in: Lancet Microbe, 2021, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00044-6

A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics

Autori: Michaela Zwyer; Cengiz Çavusoglu; Giovanni Ghielmetti; Maria Lodovica Pacciarini; Erika Scaltriti; Dick Van Soolingen; Anna Dötsch; Miriam Reinhard; Sebastien Gagneux; Daniela Brites
Pubblicato in: Open Research Europe, Numero 1, 2021, ISSN 2732-5121
Editore: European Commission
DOI: 10.12688/openreseurope.14029.2

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.

Autori: Rhastin A D Castro; Rhastin A D Castro; Sonia Borrell; Sonia Borrell; Sebastien Gagneux; Sebastien Gagneux
Pubblicato in: FEMS Microbiology Reviews, Numero 6, 2021, ISSN 0168-6445
Editore: Blackwell
DOI: 10.1093/femsre/fuaa071

Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

Autori: Zhi Ming Xu; Sina Rüeger; Michaela Zwyer; Daniela Brites; Hellen Hiza; Miriam Reinhard; Liliana Rutaihwa; Sonia Borrell; Faima Isihaka; Hosiana Temba; Thomas Maroa; Rastard Naftari; Jerry Hella; Mohamed Sasamalo; Klaus Reither; Damien Portevin; Sebastien Gagneux; Jacques Fellay
Pubblicato in: PLoS Computational Biology, Numero 1, 2022, Pagina/e e1009628, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1009628

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

Autori: Valerie F. A. March, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Galo A. Goig, Sebastien Gagneux, Sonia Borrell
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-85092-7

The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot

Autori: Chloé Loiseau, Etthel M. Windels, Sebastian M. Gygli, Levan Jugheli, Nino Maghradze, Daniela Brites, Amanda Ross, Galo Goig, Miriam Reinhard, Sonia Borrell, Andrej Trauner, Anna Dötsch, Rusudan Aspindzelashvili, Rebecca Denes, Klaus Reither, Christian Beisel, Nestani Tukvadze, Zaza Avaliani, Tanja Stadler, Sebastien Gagneux
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-37719-y

Transmission as a Key Driver of Resistance to the New Tuberculosis Drugs

Autori: Galo A. Goig, Chloé Loiseau, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Daniela Brites, Sonia Borrell, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Sebastien Gagneux
Pubblicato in: New England Journal of Medicine, Numero 392, 2025, Pagina/e 97-99, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmc2404644

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Autori: Michaela Zwyer, Liliana K. Rutaihwa, Etthel Windels, Jerry Hella, Fabrizio Menardo, Mohamed Sasamalo, Gregor Sommer, Lena Schmülling, Sonia Borrell, Miriam Reinhard, Anna Dötsch, Hellen Hiza, Christoph Stritt, George Sikalengo, Lukas Fenner, Bouke C. De Jong, Midori Kato-Maeda, Levan Jugheli, Joel D. Ernst, Stefan Niemann, Leila Jeljeli, Marie Ballif, Matthias Egger, Niaina Rakotosamimanana, Dor
Pubblicato in: PLOS Pathogens, Numero 19, 2023, Pagina/e e1010893, ISSN 1553-7374
Editore: PLOS
DOI: 10.1371/journal.ppat.1010893

Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis

Autori: Gygli SM, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S
Pubblicato in: Nature Medicine, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41591-021-01358-x

How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality

Autori: Sebastien Gagneux, Christoph Stritt
Pubblicato in: Peer Community In Evolutionary Biology, 2022, ISSN 2551-668X
Editore: Peer Community In Evolutionary Biology
DOI: 10.32942/x2gw2p